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Author profile at the institutional portal

Hernandez Perez, Felix felix.hernandez@uam.es

Biología molecular / Universidad Autónoma de Madrid

Publications

Amyloid and tau pathologies cross-talk to promote Alzheimers disease: novel mechanistic insights

  • Avila, J
  • Hernández, F
  • Perry, G

NEUROSCIENCE (p. 58-62) - 22/7/2025

10.1016/j.neuroscience.2025.07.025 View at source

  • ISSN 03064522

Retrotransposon Protein L1 ORF1p Expression in Aging Central Nervous System.

  • Vallés-Saiz, L
  • Abdelkader-Guillén, A
  • Avila, J
  • Hernández, F

International journal of molecular sciences - 4/5/2025

10.3390/ijms26094368 View at source

  • ISSN 14220067

Peptide Family Promotes Brain Cell Rejuvenation and Improved Cognition through Peripheral Delivery.

  • Anton-Fernandez, A
  • Domene-Serrano, I
  • Cuadros, R
  • Peinado-Cahuchola, R
  • Sanchez-Pece, M
  • Hernandez, F
  • Avila, J
... View more Collapse

ACS omega (p. 13236-13250) - 8/4/2025

10.1021/acsomega.4c10849 View at source

  • ISSN 24701343

Shapeshifter W-Tau Peptide Inhibits Tau Aggregation and Disintegrates Paired Helical Filaments.

  • Domene-Serrano, I
  • Cuadros, R
  • García-Escudero, V
  • Vallejo-Bedia, F
  • Santa-María, I
  • Vallés-Saiz, L
  • Hernandez, F
  • Avila, J
... View more Collapse

BIOCHEMISTRY (p. 1841-1851) - 26/3/2025

10.1021/acs.biochem.4c00809 View at source

  • ISSN 00062960

Structure and function of Full-length Tau

  • Vallés-Saiz, L
  • Domene-Serrano, I
  • Picher, AJ
  • Pérez, M
  • García-Escudero, V
  • Hernández, F
  • Avila, J
... View more Collapse

Plos One - 31/10/2025

10.1371/journal.pone.0335251 View at source

  • ISSN 19326203

Hippocampal rejuvenation by a single intracerebral injection of one-carbon metabolites in C57BL6 old wild-type mice

  • Antón-Fernández, A
  • Cauchola, RP
  • Hernández, F
  • Avila, J

AGING CELL - 1/1/2025

10.1111/acel.14365 View at source

  • ISSN 14749718

The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer's disease.

  • Sala-Jarque, Julia
  • Gil, Vanessa
  • Andres-Benito, Pol
  • Martinez-Soria, Ines
  • Picon-Pages, Pol
  • Hernandez, Felix
  • Avila, Jesus
  • Lanciego, Jose Luis
  • Nuvolone, Mario
  • Aguzzi, Adriano
  • Gavin, Rosalina
  • Ferrer, Isidro
  • del Rio, Jose Antonio
... View more Collapse

Scientific Reports - 16/9/2024

10.1038/s41598-024-72232-2

  • ISSN 20452322
  • iMarina

In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance.

  • Antón-Fernández, A.
  • Roldán-Lázaro, M.
  • Vallés-Saiz, L.
  • Ávila, J.
  • Hernández, F.

Commun Biol - 24/5/2024

10.1038/s42003-024-06328-w View at source

  • ISSN 23993642

Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3

  • Ruiz-Gabarre, D
  • Vallés-Saiz, L
  • Carnero-Espejo, A
  • Ferrer, I
  • Hernández, F
  • Garcia-Escudero, R
  • ávila, J
  • García-Escudero, V
... View more Collapse

Ebiomedicine (p. 104953-104953) - 1/2/2024

10.1016/j.ebiom.2023.104953 View at source

  • ISSN 23523964

Role of folate receptor α in the partial rejuvenation of dentate gyrus cells: Improvement of cognitive function in 21-month-old aged mice

  • Antón-Fernández, A
  • Cuadros, R
  • Peinado-Cahuchola, R
  • Hernández, F
  • Avila, J

Scientific Reports (p. 6915-6915) - 1/1/2024

10.1038/s41598-024-57095-x View at source

  • ISSN 20452322

Transgenic mice overexpressing GSK-3 beta as animal models for Alzheimer's disease

  • Hernández, F

Rsc Drug Discovery Series (p. 52-68) - 1/1/2011

10.1039/9781849732758 View at source

  • ISBN 978-1-84973-275-8
  • ISSN 20413203

Tau Phosphorylation

  • Avila, J
  • Hernández, F

Advances In Neurobiology (p. 73-82) - 1/1/2011

10.1007/978-1-4419-6787-9_3 View at source

  • ISSN 21905215

Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies

  • Engel T
  • Hernández F
  • Gómez-Sintes R
  • Ávila J
  • Lucas JJ

Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development (p. 203-219) - 6/3/2006

10.1002/9780470052174.ch11 View at source

GSK-3, a Key Player in Alzheimer's Disease

  • Hernández F
  • Avila J

Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development (p. 105-124) - 6/3/2006

10.1002/9780470052174.ch6 View at source

Measurement of cyclic GMP formation

  • Félix Hernández

Signal Transduction Protocols (p. 107-112) - 1/1/1995

10.1385/0-89603-298-1:107 View at source

  • ISSN 10643745

CPEB alteration and aberrant transcriptome-polyadenylation unveil a treatable vitamin B1 deficiency in huntington’s disease

  • Pico, S
  • Parras, A
  • Santos-Galindo, M
  • Pose-Utrilla, J
  • Castro, M
  • Fraga, E
  • Hernandez, IH
  • Elorza, A
  • Anta, H
  • Wang, N
  • Marti-Sanchez, L
  • Belloc, E
  • Garcia-Esparcia, P
  • Garrido, JJ
  • Ferrer, I
  • Macias-Garcia, D
  • Mir, P
  • Artuch, R
  • Perez, B
  • Hernandez, F
  • Navarro, P
  • Lopez-Sendon, JL
  • Iglesias, T
  • Yang, XW
  • Mendez, R
  • Lucas, JJ
... View more Collapse

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (p. A49-A49) - 1/9/2021

3196774911 View at source

  • ISSN 00223050

TAU-POSITIVE NUCLEAR INDENTATIONS IN P301S TAUOPATHY MICE

  • Fernández-Nogales, M
  • Santos-Galindo, M
  • Merchan-Rubira, J
  • Hoozemans, J
  • Rábano, A
  • Ferrer, I
  • Avila, J
  • Hernández, F
  • Lucas, JJ
... View more Collapse

Journal Of Neurology, Neurosurgery And Psychiatry (p. A25-A25) - 1/9/2016

10.1136/jnnp-2016-314597.76 View at source

  • ISSN 00223050

Huntington's disease as a tauopathy

  • Fernandez-Nogales, M.
  • Cabrera, J. R.
  • Santos-Galindo, M.
  • Hoozemans, J. J. M.
  • Ferrer, I.
  • Rozemuller, A. J. M.
  • Hernandez, F.
  • Avila, J.
  • Lucas, J. J.;
... View more Collapse

Journal Of Neurology Neurosurgery And Psychiatry (p. A17-A17) - 1/9/2014

10.1136/jnnp-2014-309032.52 View at source

  • ISSN 00223050

Co-expression of FTDP-17 human tau and GSK-3 beta (or APP(SW)) in transgenic mice: Induction of tau polymerization and neurodegeneration

  • Avila, Jesus
  • Engel, Tobias
  • Lucas, Jose J.
  • Perez, Mar
  • Rubio, Alicia
  • Hernandez, Felix;

Advances In Alzheimer's And Parkinson's Disease: Insights, Progress, And Perspectives (p. 337-342) - 1/1/2008

10.1007/978-0-387-72076-0_35 View at source

  • ISSN 00999962

Coexpression of FTDP-17 human tau and GSK-3 beta in transgenic mice synergistically act to induce tau polymerization and neurodegeneration

  • Avila, J
  • Engel, I
  • Lucas, JJ
  • Gomez-Ramos, P
  • Moran, MA
  • Hernandez, F

European Neuropsychopharmacology - 1/10/2005

  • ISSN 0924977X
  • iMarina

Different ways for tau assembly

  • Avila, J
  • Perez, M
  • Gomez, A
  • Santa-Maria, I
  • Moreno, F
  • Hernandez, F;

Neurobiology Of Aging (p. S41-S41) - 1/7/2004

10.1016/s0197-4580(04)80135-0 View at source

  • ISSN 01974580

Biochemical, ultrastructural, and reversibility studies on huntingtin filaments isolated from mouse and human brain

  • Díaz-Hernández M
  • Moreno-Herrero F
  • Gómez-Ramos P
  • Morán MA
  • Ferrer I
  • Baró AM
  • Avila J
  • Hernández F
  • Lucas JJ
... View more Collapse

Journal Of Neuroscience (p. 9361-9371) - 20/10/2004

10.1523/jneurosci.2365-04.2004 View at source

  • ISSN 15292401

Tau phosphorylation by GSK3

  • Avila, J
  • Hernandez, F
  • Gomez, A
  • Perez, M
  • Lim, F
  • Lucas, JJ

Neurobiology Of Aging (p. S8-S9) - 1/7/2002

  • ISSN 01974580
  • iMarina

Phosphorylation, microtubule binding and aggregation of tau protein in Alzheimer's disease

  • Avila, J
  • Lucas, JJ
  • Lim, F
  • Pérez, M
  • Hernández, F
  • Arrasate, M
  • Portela, RA
  • Champion, E
  • Perry, G
  • Smith, MA
  • Nido, JD
... View more Collapse

Alzheimer´s Disease: Advances In Etiology, Pathogenesis And Therapeutics (p. 601-607) - 1/1/2001

10.1002/0470846453.ch55 View at source

Differentiation of KCl-, NMDA- and glutamate-evoked cGMP accumulations in the guinea-pig cerebellum

  • Neil, KE
  • Hernandez, F
  • Kendall, DA
  • Alexander, SPH

British Journal Of Pharmacology - 1/10/1997

  • ISSN 00071188
  • iMarina

This researcher has no working papers.

This researcher has no technical reports.

Activación de transposones en modelos animales de la enfermedad de Alzheimer: implicación de la proteína tau

  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 01-09-2024 - 31-08-2027

  • iMarina

Neurorregeneración en la enfermedad de Alzheimer a través de la expresión de factores de pluripotencia in vivo

  • García García, Esther (Investigador/a)
  • CUADROS CATALAN, RAQUEL (Investigador/a)
  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 01-09-2021 - 31-08-2024

Type of funding: National

Amount of funding: 181500,00 Euros.

  • iMarina

Bases metabólicas de la neurodegeneración (NEUROMETA-CM)

  • SANCHEZ LANZAS, RAUL (Miembro del equipo de investigación)
  • Gonzalez Castaño, Jose (Investigador principal (IP))
  • Hernandez Perez, Felix (Investigador principal (IP))
  • Diaz Nido, Javier (Investigador principal (IP))

Period: 01-01-2018 - 31-12-2021

  • iMarina

BASES METABOLICAS DE LA NEURODEGENERACION - NEUROUAM3

  • Diaz Nido, Javier (Investigador principal (IP))
  • Gonzalez Castaño, Jose (Investigador principal (IP))
  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 01-01-2018 - 30-06-2022

  • iMarina

BASES METABOLICAS DE LA NEURODEGENERACION - NEUROUAM2

  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 01-01-2018 - 30-06-2022

  • iMarina

Nuevas aproximaciones al estudio del metabolismo de la GSK3B y de su principal sustrato en el sistema nervioso central, la proteína TAU: implicaciones en la neurogénesis adulta

  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 30-12-2016 - 29-12-2019

Type of funding: National

Amount of funding: 133100,00 Euros.

  • iMarina

Análisis de la función de GSK-3BETA en la neurogénesis adulta en ratones transgénicos con expresión condicional de la quinasa

  • Almudena Fuster Matanzo (Investigador/a)
  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 01-01-2014 - 31-12-2016

  • iMarina

Redes de señalización y vías efectoras en modelos celulares y animales de enfermedades neurodegenerativas. NEURODEGMODELS4 NEUROUAM3

  • Gonzalez Castaño, Jose (Investigador principal (IP))
  • Hernandez Perez, Felix (Investigador principal (IP))
  • Diaz Nido, Javier (Investigador principal (IP))

Period: 01-01-2012 - 31-12-2015

Amount of funding: 106472,00 Euros.

  • iMarina

Investigación -Redes de señalización y vías efectoras en modelos celulares y animales de enfermedades neurodegenerativas.

  • Sanchez Perez, Maria Isabel (Investigador/a)

Period: 01-01-2012 - 31-12-2015

Amount of funding: 140000,00 Euros.

  • iMarina

Activación de la ruta calpaina/GSK-3/CDK-5 en la enfermedad de Alzheimer.

  • Hernandez Perez, Felix (Investigador principal (IP))

Period: 11-01-2009 - 31-10-2012

  • iMarina

Unraveling disease mechanisms, developing preclinical models and therapeutic approaches to target MCT8 deficiency

  • Bárez López, Soledad (Director)
  • Guadaño Ferraz, Ana (Director)
  • Hernandez Perez, Felix (Tutor) Doctorando: Válcarcel Hernández, Víctor

30/6/2023

  • iMarina

Estudio de la enfermedad de Huntington como una deficiencia de tiamina asociada a slc19a3 y sus implicaciones terapéuticas

  • Lucas Lozano, José Javier (Director)
  • Hernandez Perez, Felix (Tutor) Doctorando: Picó del Pino, Sara

1/7/2022

  • iMarina

Nuevas funciones para la proteína tau en el Sistema Nervioso Central y en tejidos periféricos

  • Hernandez Perez, Felix (Director)
  • Félix Hernández Pérez (Director) Doctorando: Valles-Saiz, Laura

1/1/2022

  • iMarina

Efecto de tau en la respuesta inflamatoria de la microglía

  • Ávila de Grado, Jesús (Director)
  • Bolós Jurado, Marta (Director)
  • Hernandez Perez, Felix (Tutor) Doctorando: Perea Úbeda-Portugués, Juan Ramón

26/6/2020

  • iMarina

Envejecimiento, Alzheimer y reprogramación celular in vivo.: Efecto de la sobreexpresión de GSK-3B y de los factores de Yamanaka en el sistema nervioso central.

  • Félix Hernández Pérez (Director) Doctorando: García Rodríguez, Alberto

23/6/2020

  • iMarina

Caracterización de un modelo murino de taupatía tau-P301S: Alteraciones en el sistema nervioso periférico y central

  • Hernandez Perez, Felix (Director)
  • Ávila de Grado, Jesús (Director) Doctorando: Merchan Rubira, Jesus

1/1/2020

  • iMarina

Evaluación de compuestos antitumorales dirigidos contra tubulina e implicación en los mecanismos estructurales de control del citoesqueleto

  • Díaz Pereira, J. Fernando (Director)
  • Josa Prado, Fernando (Director)
  • Hernandez Perez, Felix (Tutor) Doctorando: Balaguer Pérez, Francisco de Asís

28/6/2019

  • iMarina

Molecular mechanisms that control synapse number and activity.

  • Alberto Ferrús Gamero (Director)
  • Sergio Casas-Tintó (Director)
  • Hernandez Perez, Felix (Tutor) Doctorando: Elena Santana Martin

11/5/2018

  • iMarina

The effect of age on brain insulin signalling

  • Mayor Menendez, Federico (Autor o Coautor)
  • Adrián Martín (Director)
  • Hernandez Perez, Felix (Autor o Coautor) Doctorando: Adrián Martín

1/1/2017

  • iMarina

Estudio del papel de la proteína TAU en la modulación de la neurogénesis hipocampal adulta

  • LLORENS MARTIN, MARIA VICTORIA (Director) Doctorando: Noemí Pallas Bazarra

17/7/2015

  • iMarina

Peptide for cognitive improvement

  • Hernandez Perez, Felix (Autor o Coautor)

1/1/2025

  • iMarina

A new non- aggregative splicing isoform of human tau is decreased in alzheimers disease

  • García-Escudero Barreras, María Vega (Autor o Coautor)
  • Hernandez Perez, Felix (Autor o Coautor)
  • Ruiz Gabarre, Daniel (Autor o Coautor)

13/10/2022

  • iMarina

Uso de Compuestos Que Se Unen Al Dominio de Union A Microtubulos de Tau en la Elaboracion de Composiciones Farmaceuticas, Dichas Composiciones Farmaceuticas y Su Aplicacion en el Tratamiento de Tautopatias

  • Hernandez Perez, Felix (Autor o Coautor)

26/1/2006

  • iMarina

GSK-3 beta expressed in a transgenic mouse

  • Hernandez Perez, Felix (Inventores/autores/obtentores)

18/9/2003

  • iMarina

New transgenic animal in which glycogen synthase kinase-3 beta protein is over-expressed, useful as model for neurodegenerative disease such as Alzheimer's disease

  • Hernandez Perez, Felix (Autor o Coautor)

18/5/2000

  • iMarina
Last data update: 3/11/26 9:26 AM