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Author profile at the institutional portal

Penela Marquez, Petronila petronila.penela@uam.es

Biología molecular / Universidad Autónoma de Madrid

Publications

Engineered T cells secreting anti-BCMA T cell engagers control multiple myeloma and promote immune memory in vivo

  • Díez-Alonso, L
  • Falgas, A
  • Arroyo-Ródenas, J
  • Romencín, PA
  • Martínez, A
  • Gomez-Rosel, M
  • Blanco, B
  • Jiménez-Reinoso, A
  • Mayado, A
  • Perez-Pons, A
  • Aguilar-Sopeña, O
  • Ramirez-Fernández, A
  • Segura-Tudela, A
  • Pérez-Amill, L
  • Tapia-Galisteo, A
  • Domínguez-Alonso, C
  • Rubio-Peréz, L
  • Jara, M
  • Solé, F
  • Hangiu, O
  • Almagro, L
  • Albitre, A
  • Penela, P
  • Sanz, L
  • Anguita, E
  • Valeri, A
  • García-Ortiz, A
  • Río, P
  • Juan, ME
  • Martínez-López, J
  • Roda-Navarro, P
  • Martín-Antonio, B
  • Orfao, A
  • Menéndez, P
  • Bueno, C
  • alvarez-Vallina, L
... View more Collapse

Science Translational Medicine (p. eadg7962-eadg7962) - 14/2/2024

10.1126/scitranslmed.adg7962

  • ISSN 19466234
  • iMarina

The stress connection in cancer: the adrenergic fuelling of breast tumors

  • Albitre, A.
  • Reglero, C.
  • González-Muñoz, T.
  • Penela, P.

Curr Opin Physiol - 1/12/2023

10.1016/j.cophys.2023.100720 View at source

  • ISSN 24688673

Efficient preclinical treatment of cortical T cell acute lymphoblastic leukemia with T lymphocytes secreting anti-CD1a T cell engagers

  • Jimenez-Reinoso, Anais
  • Tirado, Nestor
  • Martinez-Moreno, Alba
  • Diaz, Victor M.
  • Garcia-Peydro, Marina
  • Hangiu, Oana
  • Diez-Alonso, Laura
  • Albitre, Angela
  • Penela, Petronila
  • Toribio, Maria L.
  • Menendez, Pablo
  • Alvarez-Vallina, Luis
  • Sanchez Martinez, Diego;
... View more Collapse

Journal For Immunotherapy Of Cancer - 1/12/2022

10.1136/jitc-2022-005333 View at source

  • ISSN 20511426

Crosstalk between CXCR4/ACKR3 and EGFR Signaling in Breast Cancer Cells

  • Neves, Maria
  • Marolda, Viviana
  • Mayor, Federico
  • Penela, Petronila;

International Journal Of Molecular Sciences - 1/10/2022

10.3390/ijms231911887 View at source

  • ISSN 14220067

Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression

  • Reglero, Clara
  • Ortiz del Castillo, Belen
  • Rivas, Veronica
  • Mayor Jr, Federico
  • Penela, Petronila;

Cells - 1/4/2021

10.3390/cells10040729 View at source

  • ISSN 20734409

G protein–coupled receptor kinase 2 at crossroads of metabolic and cardiovascular diseases

  • Arcones AC
  • Murga C
  • Penela P
  • Inserte J
  • Mayor F

Curr Opin Endocr Metab Res (p. 75-85) - 1/2/2021

10.1016/j.coemr.2020.09.004 View at source

  • ISSN 24519650

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

  • Smit, Martine J.
  • Schlecht-Louf, Geraldine
  • Neves, Maria
  • van den Bor, Jelle
  • Penela, Petronila
  • Siderius, Marco
  • Bachelerie, Francoise
  • Mayor, Federico, Jr.;
... View more Collapse

Annual Review Of Pharmacology And Toxicology (p. 541-563) - 1/1/2021

10.1146/annurev-pharmtox-010919-023340 View at source

  • ISSN 03621642

Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2

  • Neves M
  • Perpiñá-Viciano C
  • Penela P
  • Hoffmann C
  • Mayor F

Acs Pharmacology And Translational Science (p. 627-634) - 14/8/2020

10.1021/acsptsci.0c00021 View at source

  • ISSN 25759108

GRK2-dependent HuR phosphorylation regulates HIF1α activation under hypoxia or adrenergic stress

  • Reglero C., Lafarga V., Rivas V., Albitre Á., Ramos P., Berciano S.R., Tapia O., Martínez-Chantar M.L., Mayor F., Penela P.

Cancers - 1/5/2020

10.3390/cancers12051216 View at source

  • ISSN 20726694

Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2

  • Aluja, David
  • Inserte, Javier
  • Penela, Petronila
  • Ramos, Paula
  • Ribas, Catalina
  • Angel Iniguez, Miguel
  • Mayor, Federico, Jr.
  • Garcia-Dorado, David;
... View more Collapse

Basic Research In Cardiology - 1/5/2019

10.1007/s00395-019-0730-5 View at source

  • ISSN 03008428

This researcher has no books.

Cell-Type Specific GRK2 Interactomes: Pathophysiological Implications

  • Mayor, Federico, Jr.
  • Vila-Bedmar, Rocio
  • Nogues, Laura
  • Cruces-Sande, Marta
  • Lucas, Elisa
  • Rivas, Veroica
  • Reglero, Clara
  • Penela, Petronila
  • Murga, Cristina;
... View more Collapse

Methods In Pharmacology And Toxicology (p. 123-149) - 1/1/2016

10.1007/978-1-4939-3798-1_6 View at source

  • ISSN 15572153

The Complex Role of G Protein-coupled Receptor Kinase 2 (GRK2) in Cell Signalling: Beyond GPCR Desensitization

  • Mayor, Federico, Jr.
  • Penela, Petronila
  • Ribas, Catalina
  • Murga, Cristina;

Rsc Drug Discovery Series (p. 316-334) - 1/1/2011

10.1039/9781849733441-00316 View at source

  • ISSN 20413203

Adrenoceptors and their G Protein-Coupled Receptor Interacting Proteins (GIPs): Roles in Receptor Signaling and Regulation

  • Penela Marquez, Petronila

Molecular Aspects Of G Protein-Coupled Receptors (p. 29-60) - 1/1/2007

  • iMarina

Patología Molecular de los sistemas de señalización beta-adrenérgicos

  • Penela Marquez, Petronila

Enfermedades Metabólicas (p. 315-337) - 1/1/2006

  • iMarina

Mecanismos de regulación de receptores heptahélicos acoplados a proteínas G

  • Penela Marquez, Petronila

Receptores Para Neurotransmisores (p. 355-373) - 1/1/2003

  • iMarina

β-adrenergic receptor kinase: physiological roles and subcellular distribution

  • Ruiz Gomez, Ana
  • Penela Marquez, Petronila
  • Murga Montesinos, Cristina

Cell Signal Transduction, Second Messengers And Protein Phosphorylation In Health And Disease (p. 129-138) - 1/1/1994

  • iMarina

Mechanisms involved in the very rapid desensitization of the rat liver B-adrenergic receptors in the perinatal period

  • Penela Marquez, Petronila
  • Murga Montesinos, Cristina

Physiological Basis Of Perinatal Care (p. 251-254) - 1/1/1993

  • iMarina

Oral pharmacological inhibition of calpains attenuates isoproterenol-induced myocardial hypertrophy and fibrosis

  • Aluja, D.
  • Inserte, J.
  • Castellano, J.
  • Penela, P.
  • Mayor, F.
  • Garcia-Dorado, D.;

Journal Of Molecular And Cellular Cardiology (p. 14-14) - 1/7/2018

10.1016/j.yjmcc.2018.05.050 View at source

  • ISSN 00222828

Modulation of GRK2 levels and functionality in myocardial ischemia/reperfusion and impact in the regulation of cardioprotective signaling pathways

  • Penela, P.
  • Ramos, P.
  • Inserte, J.
  • Gracia-Dorado, D.
  • Mayor, F.;

European Journal Of Clinical Investigation (p. 128-128) - 1/6/2018

  • ISSN 00142972
  • iMarina

Oral pharmacological inhibition of calpains attenuates isoproterenol-induced myocardial hypertrophy and fibrosis

  • Aluja, D.
  • Inserte, J.
  • Castellano, J.
  • Penela, P.
  • Mayor, F.
  • Garcia-Dorado, D.;

European Journal Of Clinical Investigation (p. 123-124) - 1/6/2018

  • ISSN 00142972
  • iMarina

Inhibition of Calpains Attenuates Isoproterenol-Induced Myocardial Remodeling Through Modulation of GRK2

  • Inserte, Javier
  • Aluja, David
  • Penela, Petronila
  • Rivas, Catalina
  • Iniguez, Miguel A.
  • Mayor, Federico
  • Garcia-Dorado, David;
... View more Collapse

Circulation - 6/11/2018

  • ISSN 00097322
  • iMarina

Implicaciones Fisiológicas de la quinasa GRK2 en cáncer de mama

  • Penela Marquez, Petronila

27/1/2017

  • iMarina

G PROTEIN-COUPLED RECEPTOR KINASES: FROM GPCR MODULATION TO SIGNALLING HUBS

  • Mayor, F., Jr.
  • Murga, C.
  • Penela, P.;

Inflammation Research (p. S40-S40) - 1/7/2015

  • ISSN 10233830
  • iMarina

New functions of GRK2 in epithelial cell migration

  • Penela Marquez, Petronila

17/11/2013

  • iMarina

G protein-coupled receptor kinase 2 (GRK2) contributes to cellular transformation and breast tumor progression

  • Vera, L. N.
  • Salcedo, A.
  • Mendiola, M.
  • Hardisson, D.
  • Mayor, F.
  • Penela, P.;

Febs Journal (p. 138-138) - 1/9/2012

  • ISSN 1742464X
  • iMarina

Role of GRK2 in developing vasculature and pathological angiogenesis

  • Rivas, V.
  • Chapuli, R. M.
  • Mayor, F.
  • Penela, P.;

Febs Journal (p. 547-547) - 1/9/2012

  • ISSN 1742464X
  • iMarina

Degradation of GRK2 is cell cycle regulated by Mdm2 and APC/C ubiquitin ligases

  • Gomez, C. R.
  • Rivas, V.
  • Mayor, F., Jr.
  • Penela, P.;

Febs Journal (p. 142-142) - 1/9/2012

  • ISSN 1742464X
  • iMarina

This researcher has no working papers.

This researcher has no technical reports.

Vías de señalización mediadas por receptores acoplados a proteínas G y la quinasa GRK2 y su relación con procesos fisiopatológicos

  • Serrano Puebla, Ana (Investigador/a)
  • CABEZUDO VIOLERO, SOFIA (Investigador/a)
  • Concepcion Arcones, Alba (Investigador/a)
  • Rivas Guerrero, Veronica (Investigador/a)
  • Penela Marquez, Petronila (Investigador/a)
  • Murga Montesinos, Cristina (Investigador/a)
  • Martins Neves, Maria Margarita (Investigador/a)
  • Asensio Lopez, Alejandro (Investigador/a)
  • Caballero Lombraña, Alvaro (Investigador/a)
  • SANZ FLORES, MARIA (Investigador/a)
  • Ribas Nuñez, Catalina (Investigador/a)
  • Mayor Menendez, Federico (Investigador principal (IP))
... View more Collapse

Period: 01-10-2018 - 30-09-2021

Type of funding: Regional

Amount of funding: 25000,00 Euros.

  • iMarina

Nuevos mecanismos moleculares y celulares implicados en la fisiopatología inmune y enfermedades inflamatorias

  • Ribas Nuñez, Catalina (Investigador/a)
  • Penela Marquez, Petronila (Investigador/a)
  • Murga Montesinos, Cristina (Investigador/a)
  • Mayor Menendez, Federico (Investigador principal (IP))
  • CABEZUDO VIOLERO, SOFIA (Investigador/a)
  • TORRES GERICA, PATRICIA (Investigador/a)
  • Stamatakis Andriani, Konstantinos (Investigador/a)
  • GARCIA PRIETO, TERESA (Investigador/a)
  • Arranz De Miguel, Alicia (Investigador/a)
  • Galan Martinez, Javier (Investigador/a)
  • Fresno Escudero, Manuel (Investigador principal (IP))
... View more Collapse

Period: 01-01-2018 - 31-12-2021

Type of funding: Regional

Amount of funding: 61525,00 Euros.

  • iMarina

Oncogenic receptor network of excellence and training (ONCORNET).

  • Penela Marquez, Petronila (Investigador/a)
  • Mayor Menendez, Federico (Investigador principal (IP))

Period: 01-01-2015 - 31-12-2018

Type of funding: European

Amount of funding: 216000,00 Euros.

  • iMarina

Interrelación de GRK2 con Mdm2 y ATM en inestabilidad genómica por estrés metabólico y en la invasividad celular y angiogénesis: oportunidades terapéuticas en cáncer de mama

  • Penela Marquez, Petronila (Investigador principal (IP))

Period: 01-01-2015 - 31-12-2017

Type of funding: National

Amount of funding: 166,98 Euros.

  • iMarina

RD12/0042/0057 - Red Cardiovascular

  • Acosta Iborra, Maria Barbara (Investigador/a)
  • Angel Ordoñez Navadijo (Investigador/a)
  • Calzada Garcia, Maria Josefa (Investigador/a)
  • Aragones Lopez, Julian (Investigador/a)
  • Glenn Marsboom (Investigador/a)
  • Florinda del Coral Melendez Rodriguez (Investigador/a)
  • Balsa Martinez, Eduardo (Investigador/a)
  • Elorza Peregrina, Ainara Estibaliz (Investigador/a)
  • Ortiz de Landazuri Busca, Manuel (Investigador principal (IP))
... View more Collapse

Period: 01-10-2013 - 31-12-2016

Type of funding: National

Funding entity: INSTITUTO DE SALUD CARLOS III

Estudio de las implicaciones funcionales de la serina-treonina quinasa GRK2 en la Telangectasia Hemorrágica Hereditaria

  • Penela Marquez, Petronila (Investigador principal (IP))

Period: 25-06-2012 - 24-05-2015

Type of funding: National

Amount of funding: 78,49 Euros.

  • iMarina

Estudio de la regulación funcional de Mdm2 por la serina-treonina kinasa GRK2 en la modulación de p53 y la progresión tumoral: implicaciones en inestabilidad genómica y cáncer de mama

  • Penela Marquez, Petronila (Investigador principal (IP))

Period: 01-03-2012 - 28-02-2013

  • iMarina

La quinasa GRK2 (Gprotein-coupled recptor kinase 2) como un nodo central en las redes de señalización celular Papel en fisiopatología.

  • Cruces Sande, Marta (Investigador/a)
  • Julia Palacios Garcia (Investigador/a)
  • Lucas Fernandez, Elisa (Investigador/a)
  • Nogues Vera, Laura (Investigador/a)
  • Veronica Rivas Guerrero (Investigador/a)
  • Lafarga Berciano, Vanesa (Investigador/a)
  • Susana Rojo Berciano (Investigador/a)
  • Vila Bedmar, Rocio (Investigador/a)
  • Penela Marquez, Petronila (Investigador/a)
  • Murga Montesinos, Cristina (Investigador/a)
  • Mayor Menendez, Federico (Investigador principal (IP))
... View more Collapse

Period: 01-01-2011 - 31-12-2014

  • iMarina

Repercusiones de la regulación de Mdm2 y p53 por la quinasa GRK2 en cáncer de mama: estabilidad genómica y quimioresistencia

  • Penela Marquez, Petronila (Investigador principal (IP))

Period: 01-01-2011 - 01-01-2014

  • iMarina

Quinasas de receptores acoplados a proteínas G (GRKS): inteactoma e implicaciones fisiopatológicas.

  • Raul Alvarado Arroyo (Investigador/a)
  • Nogues Vera, Laura (Investigador/a)
  • Lafarga Berciano, Vanesa (Investigador/a)
  • Susana Rojo Berciano (Investigador/a)
  • Penela Marquez, Petronila (Investigador/a)
  • Murga Montesinos, Cristina (Investigador/a)
  • Ribas Nuñez, Catalina (Investigador/a)
  • Ruiz Gomez, Ana (Investigador/a)
  • Mayor Menendez, Federico (Investigador principal (IP))
... View more Collapse

Period: 01-01-2009 - 31-12-2011

  • iMarina

Understanding the role of Retinoid X Receptors in cardiac homeostasis: from transcription to physiology

  • Ricote Pacheco, María Mercedes (Director)
  • Penela Marquez, Petronila (Tutor) Doctorando: Paredes García, Ana

3/2/2023

  • iMarina

Role of GRK2 in orienting cell division and cell cycle decision-making to proliferation

  • Petronila Penela Márquez (Director) Doctorando: Belén Ortiz del Castillo

1/1/2023

  • iMarina

The mTORC1 signaling pathway: novel phosphorylation targets and physiological impact of genetic variants

  • Efeyan, Alejo (Director)
  • Penela Marquez, Petronila (Tutor) Doctorando: Deleyto Seldas, Nerea

17/6/2022

  • iMarina

Modeling MYBPC3-and ACTC1-related Hypertrophic Cardiomyopathy and LeftVentricular Non-Compaction in mice

  • Pompa Mínguez, José Luis de la (Director)
  • Penela Marquez, Petronila (Tutor) Doctorando: Salguero Jiménez, Alejandro

25/2/2022

  • iMarina

Regulation of Myc expression in mouse pluripotent stem cells and its relevance in cell competition

  • Torres Sánchez, Miguel (Director)
  • Penela Marquez, Petronila (Tutor) Doctorando: Li Bao, Lin

19/1/2022

  • iMarina

G Protein Coupled Receptor Kinase (GRK)-2: Involvement in DNA Damage Response and Functional Repercussions in Senescence

  • Penela Marquez, Petronila (Director)
  • GARCIA HIGUERA, IRENE (Otros) Doctorando: Molejón-García, Adolfo Javier

9/6/2021

  • iMarina

Molecular mechanisms underlying the role of GRK2 in breast cancer

  • Penela Marquez, Petronila (Director)
  • Mayor Menendez, Federico (Director)
  • MARTINS NEVES, MARIA MARGARIDA (Otros)
  • Fresno Escudero, Manuel (Tutor) Doctorando: Martins Neves, María Margarida

5/3/2021

  • iMarina

Oligomerización de CXCR4, una nueva diana para modular las funciones mediadas por CXCL12

  • Mellado García, Jose Mario (Director)
  • Penela Marquez, Petronila (Tutor) Doctorando: Martínez Gómez, Pablo

17/6/2020

  • iMarina

Papel de la proteasa MT4 MMP como modulador de los monocitos patrulleros en el contexto inflamatorio

  • Sanchez Madrid, Francisco (Autor o Coautor)
  • Penela Marquez, Petronila (Tutor)
  • Garcia Arroyo, Alicia (Autor o Coautor) Doctorando: Clemente Toribio, Cristina

28/2/2020

  • iMarina

New insights in p38MAPK function and potential value as therapeutic target for high prevalence diseases

  • Cuenda Méndez, Ana Isabel (Director)
  • Penela Marquez, Petronila (Tutor) Doctorando: Escós López, Alejandra

26/7/2019

  • iMarina

GRK2 como terapia antitumoral

  • Ruiz Gomez, Ana (Inventores/autores/obtentores)
  • Penela Marquez, Petronila (Inventores/autores/obtentores)
  • Mayor Menendez, Federico (Inventores/autores/obtentores)

12/12/2008

  • iMarina

Empleo de siRNA para la inhibición de la expresión de la quinasa GRK2 como estrategia antitumoral

  • Penela Marquez, Petronila (Autor o Coautor)
  • Salcedo, A (Autor o Coautor)
  • Ruiz-Gómez, A (Autor o Coautor)

11/12/2007

  • iMarina
Last data update: 8/28/24 4:56 PM