Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats - Ucha, M.; Coria, S.M.; Núñez, A.E.; Santos-Toscano, R.; Roura-Martínez, D.; Fernández-Ruiz, J.; Higuera-Matas, A.; Ambrosio, E. (JOURNAL OF PSYCHOPHARMACOLOGY, 2019)

Mu-Opioid Receptors in Ganglia, But Not in Muscle, Mediate Peripheral Analgesia in Rat Muscle Pain - Bagues, A.; Martín, M.I.; Higuera-Matas, A.; Esteban-Hernández, J.; Ambrosio, E.; María Sánchez-Robles, E. (Anesthesia And Analgesia, 2018)

Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain (vol 13, pg 411, 2011) - Higuera-Matas, A.; Soto-Montenegro, M.L.; Montoya, G.L.; García-Vázquez, V.; Pascau, J.; Migúns, M.; Del Olmo, N.; Vaquero, J.J.; García-Lecumberri, C.; Desco, M.; Ambrosio, E. (Molecular Imaging And Biology, 2011)

Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain - Higuera-Matas, A.; Soto-Montenegro, M.L.; Montoya, G.L.; García-Vázquez, V.; Pascau, J.; Miguéns, M.; Del Olmo, N.; Vaquero, J.J.; García-Lecumberri, C.; Desco, M.; Ambrosio, E. (Molecular Imaging And Biology, 2011)

Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "ecstasy") exhibit increased ethanol consumption and preference - Izco, M.; Marchant, I.; Escobedo, I.; Peraile, I.; Delgado, M.; Higuera-Matas, A.; Olias, O.; Ambrosio, E.; O'Shea, E.; Colado, M.I. (Journal of Pharmacology and Experimental Therapeutics, 2007)

DREAM controls the on/off switch of specific activity-dependent transcription pathways - Mellström, B.; Sahún, I.; Ruiz-Nuño, A.; Murtra, P.; Gomez-Villafuertes, R.; Savignac, M.; Oliveros, J.C.; Gonzalez, P.; Kastanauskaite, A.; Knafo, S.; Zhuo, M.; Higuera-Matas, A.; et al. (Molecular and Cellular Biology, 2014)

Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats - Rivera, P.; Miguéns, M.; Coria, S.M.; Rubio, L.; Higuera-Matas, A.; Bermúdez-Silva, F.J.; De Fonseca, F.R.; Suárez, J.; Ambrosio, E. (International Journal of Neuropsychopharmacology, 2013)

The effects of combined intravenous cocaine and ethanol self-administration on the behavioral and amino acid profile of young adult rats - Marcos, A.; Moreno, M.; Orihuel, J.; Ucha, M.; De Paz, A.M.; Higuera-Matas, A.; Capellán, R.; Crego, A.L.; Martínez-Larrañaga, M.-R.; Ambrosio, E.; Anadón, A. (PLoS ONE, 2020)

MouBeAT: A new and open toolbox for guided analysis of behavioral tests in mice - Bello-Arroyo, E.; Roque, H.; Marcos, A.; Orihuel, J.; Higuera-Matas, A.; Desco, M.; Caiolfa, V.R.; Ambrosio, E.; Lara-Pezzi, E.; Gómez-Gaviro, M.V. (Frontiers in Behavioral Neuroscience, 2018)

Augmented acquisition of cocaine self-administration and altered brain glucose metabolism in adult female but not male rats exposed to a cannabinoid agonist during adolescence - Higuera-Matas, A.; Luisa Soto-Montenegro, M.; Del Olmo, N.; Miguéns, M.; Torres, I.; José Vaquero, J.; Sánchez, J.; García-Lecumberri, C.; Desco, M.; Ambrosio, E. (Neuropsychopharmacology, 2008)

Central nucleus of the amygdala as a common substrate of the incubation of drug and natural reinforcer seeking - Roura-Martínez, D.; Ucha, M.; Orihuel, J.; Ballesteros-Yáñez, I.; Castillo, C.A.; Marcos, A.; Ambrosio, E.; Higuera-Matas, A. (Addiction Biology, 2020)

Changes in D1 but not D2 dopamine or mu-opioid receptor expression in limbic and motor structures after lateral hypothalamus electrical self-stimulation: A quantitative autoradiographic study - Simon, M.J.; Higuera-Matas, A.; Roura-Martinez, D.; Ucha-Tortuero, M.; Santos-Toscano, R.; Garcia-Lecumberri, C.; Ambrosio, E.; Puerto, A. (Neurobiology of Learning and Memory, 2016)

Strain differences in the expression of endocannabinoid genes and in cannabinoid receptor binding in the brain of Lewis and Fischer 344 rats - Coria, S.M.; Roura-Martínez, D.; Ucha, M.; Assis, M.A.; Miguéns, M.; García-Lecumberri, C.; Higuera-Matas, A.; Ambrosio, E. (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014)

Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats - García-Lecumberri, C.; Torres, I.; Martín, S.; Crespo, J.A.; Miguéns, M.; Nicanor, C.; Higuera-Matas, A.; Ambrosio, E. (Journal of Psychopharmacology, 2011)

Differential gene expression in the nucleus accumbens and frontal cortex of Lewis and Fischer 344 rats relevant to drug addiction - Higuera-Matas, A.; Montoya, G.L.; Coria, S.M.; Miguéns, M.; García-Lecumberri, C.; Ambrosio, E. (Current Neuropharmacology, 2011)

Neural changes developed during the extinction of cocaine self-administration behavior - Higuera-Matas, A.; Miguens, M.; del Olmo, N.; García-Lecumberri, C.; Ambrosio, E. (Pharmaceuticals, 2011)

Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain - Higuera-Matas, A.; Botreau, F.; Del Olmo, N.; Miguéns, M.; Olías, O.; Montoya, G.L.; García-Lecumberri, C.; Ambrosio, E. (European Neuropsychopharmacology, 2010)

Chronic periadolescent cannabinoid treatment enhances adult hippocampal PSA-NCAM expression in male Wistar rats but only has marginal effects on anxiety, learning and memory - Higuera-Matas, A.; Botreau, F.; Miguéns, M.; Del Olmo, N.; Borcel, E.; Pérez-Álvarez, L.; García-Lecumberri, C.; Ambrosio, E. (Pharmacology Biochemistry and Behavior, 2009)

Strain differences between Lewis and Fischer 344 rats in the modulation of dopaminergic receptors after morphine self-administration and during extinction - Sánchez-Cardoso, P.; Higuera-Matas, A.; Martín, S.; Miguéns, M.; Del Olmo, N.; García-Lecumberri, C.; Ambrosio, E. (Neuropharmacology, 2009)

Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration - Miguéns, M.; Crespo, J.A.; Del Olmo, N.; Higuera-Matas, A.; Montoya, G.L.; García-Lecumberri, C.; Ambrosio, E. (Neuropharmacology, 2008)

Sex-dependent effects of periadolescent exposure to the cannabinoid agonist CP-55,940 on morphine self-administration behaviour and the endogenous opioid system - Biscaia, M.; Fernández, B.; Higuera-Matas, A.; Miguéns, M.; Viveros, M.-P.; García-Lecumberri, C.; Ambrosio, E. (Neuropharmacology, 2008)

Glutamate and aspartate levels in the nucleus accumbens during cocaine self-administration and extinction: A time course microdialysis study - Miguéns, M.; Del Olmo, N.; Higuera-Matas, A.; Torres, I.; García-Lecumberri, C.; Ambrosio, E. (Psychopharmacology, 2008)

Cocaine self-administration improves performance in a highly demanding water maze task - Del Olmo, N.; Higuera-Matas, A.; Miguéns, M.; García-Lecumberri, C.; Ambrosio, E. (Psychopharmacology, 2007)

Modulation of the endogenous opioid system after morphine self-administration and during its extinction: A study in Lewis and Fischer 344 rats - Sánchez-Cardoso, P.; Higuera-Matas, A.; Martín, S.; del Olmo, N.; Miguéns, M.; García-Lecumberri, C.; Ambrosio, E. (Neuropharmacology, 2007)

Enhancement of hippocampal long-term potentiation induced by cocaine self-administration is maintained during the extinction of this behavior - del Olmo, N.; Miguéns, M.; Higuera-Matas, A.; Torres, I.; García-Lecumberri, C.; Solís, J.M.; Ambrosio, E. (Brain Research, 2006)

Hippocampal synaptic plasticity and water maze learning in cocaine self-administered rats - Del Olmo, N.; Higuera-Matas, A.; Miguéns, M.; García-Lecumberri, C.; Borcel, E.; Solís, J.M.; Ambrosio, E. (Annals of the New York Academy of Sciences, 2006)

Comparative analysis of the modulation of perineuronal nets in the prefrontal cortex of rats during protracted withdrawal from cocaine, heroin and sucrose self-administration - Roura-Martínez, D.; Díaz-Bejarano, P.; Ucha, M.; Paiva, R.R.; Ambrosio, E.; Higuera-Matas, A. (Neuropharmacology, 2020)

Maternal immune activation is associated with a lower number of dopamine receptor 3-expressing granulocytes with no alterations in cocaine reward, resistance to extinction or cue-induced reinstatement - Santos-Toscano, R.; Ucha, M.; Borcel, É.; Ambrosio, E.; Higuera-Matas, A. (Pharmacology Biochemistry and Behavior, 2020)

Impulsive action and impulsive choice are differentially associated with gene expression variations of the GABAA receptor alfa 1 subunit and the CB1 receptor in the lateral and medial orbitofrontal cortices - Ucha, M.; Roura-Martínez, D.; Contreras, A.; Pinto-Rivero, S.; Orihuel, J.; Ambrosio, E.; Higuera-Matas, A. (Frontiers in Behavioral Neuroscience, 2019)

Selective effects of ?9-tetrahydrocannabinol on medium spiny neurons in the striatum - Fernández-Cabrera, M.R.; Higuera-Matas, A.; Fernaud-Espinosa, I.; DeFelipe, J.; Ambrosio, E.; Miguéns, M. (PLoS ONE, 2018)

Extended-access methamphetamine self-administration elicits neuroinflammatory response along with blood-brain barrier breakdown - Gonçalves, J.; Leitão, R.A.; Higuera-Matas, A.; Assis, M.A.; Coria, S.M.; Fontes-Ribeiro, C.; Ambrosio, E.; Silva, A.P. (Brain, Behavior, and Immunity, 2017)

Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex - Fernández-Cabrera, M.R.; Selvas, A.; Miguéns, M.; Higuera-Matas, A.; Vale-Martínez, A.; Ambrosio, E.; Martí-Nicolovius, M.; Guillazo-Blanch, G. (Neuroscience, 2017)

Strain differences in cannabinoid-reinforced lever press discrimination - Coria, S.M.; Roura-Martínez, D.; Ucha, M.; Orihuel, J.; Higuera-Matas, A.; Ambrosio, E. (Journal of Drug and Alcohol Research, 2017)

Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia - Santos-Toscano, R.; Borcel, É.; Ucha, M.; Orihuel, J.; Capellán, R.; Roura-Martínez, D.; Ambrosio, E.; Higuera-Matas, A. (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2016)

Long-term consequences of perinatal and adolescent cannabinoid exposure on neural and psychological processes - Higuera-Matas, A.; Ucha, M.; Ambrosio, E. (Neuroscience and Biobehavioral Reviews, 2015)

Cocaine facilitates protein synthesis-dependent LTP: The role of metabotropic glutamate receptors - Fole, A.; Miguens, M.; Higuera-Matas, A.; Alguacil, L.F.; Ambrosio, E.; Del Olmo, N. (European Neuropsychopharmacology, 2014)

Genetic differences in the modulation of accumbal glutamate and ?-amino butyric acid levels after cocaine-induced reinstatement - Miguéns, M.; Botreau, F.; Olías, O.; Del Olmo, N.; Coria, S.M.; Higuera-Matas, A.; Ambrosio, E. (Addiction Biology, 2013)

CNR1 gene deletion affects the density of endomorphin-2 binding sites in the mouse brain in a hemisphere-specific manner - Paldy, E.; Borcel, E.; Higuera-Matas, A.; López-Montoya, G.; Wenger, T.; Toth, G.; Borsodi, A.; Ambrosio, E. (European Journal of Pharmacology, 2013)

Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure - Higuera-Matas, A.; Miguéns, M.; Coria, S.M.; Assis, M.A.; Borcel, E.; Del Olmo, N.; Ambrosio, E. (Neuropharmacology, 2012)

Immunoglobulin G Fc receptor deficiency prevents Alzheimer-like pathology and cognitive impairment in mice - Fernandez-Vizarra, P; Lopez-Franco, O; Mallavia, B; Higuera-Matas, A; Lopez-Parra, V; Ortiz-Muñoz, G; Ambrosio, E; Egido, J; Almeida, OFX; Gomez-Guerrero, C (Brain, 2012)

Depotentiation of hippocampal long-term potentiation depends on genetic background and is modulated by cocaine self-administration - Miguéns, M.; Coria, S.M.; Higuera-Matas, A.; Fole, A.; Ambrosio, E.; Del Olmo, N. (Neuroscience, 2011)

Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances - Ren, Y.; Whittard, J.; Higuera-Matas, A.; Morris, C.V.; Hurd, Y.L. (Journal of Neuroscience, 2009)

The role of the mTOR pathway in models of drug-induced reward and the behavioural constituents of addiction - Ucha, M.; Roura-Martínez, D.; Ambrosio, E.; Higuera-Matas, A. (Journal of Psychopharmacology, 2020)

Cocaine-induced Fos expression in the rat brain: Modulation by prior ?9-tetrahydrocannabinol exposure during adolescence and sex-specific effects - Orihuel, J.; Gómez-Rubio, L.; Valverde, C.; Capellán, R.; Roura-Martínez, D.; Ucha, M.; Ambrosio, E.; Higuera-Matas, A. (Brain Research, 2021)

Ex vivo 1H-MRS brain metabolic profiling in a two-hit model of neurodevelopmental disorders: Prenatal immune activation and peripubertal stress - Capellán, R.; Moreno-Fernández, M.; Orihuel, J.; Roura-Martínez, D.; Ucha, M.; Ambrosio, E.; Higuera-Matas, A. (Schizophrenia Research, 2022)

? 9-Tetrahydrocannabinol during adolescence reprograms the nucleus accumbens transcriptome, affecting reward processing, impulsivity, and specific aspects of cocaine addiction-like behavior in a sex-dependent manner - Orihuel, J.; Capellán, R.; Roura-Martínez, D.; Ucha, M.; Ambrosio, E.; Higuera-Matas, A. (International Journal of Neuropsychopharmacology, 2021)

The Basolateral Amygdala to Nucleus Accumbens Core Circuit Mediates the Conditioned Reinforcing Effects of Cocaine-Paired Cues on Cocaine Seeking - Puaud, M.; Higuera-Matas, A.; Brunault, P.; Everitt, B.J.; Belin, D. (Biological Psychiatry, 2021)

The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats - Marcos, A.; Ballesteros-Yáñez, I.; Castillo-Sarmiento, C.A.; Pardo, F.; Roura-Martínez, D.; Muñoz-Rodríguez, J.R.; Higuera-Matas, A.; Ambrosio, E. (Neuropharmacology, 2022)

Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats - Ucha, M.; Roura-Martínez, D.; Santos-Toscano, R.; Capellán, R.; Ambrosio, E.; Higuera-Matas, A. (Psychopharmacology, 2022)

Editorial: Neurobehavioral Mechanisms of Reward: Theoretical and Technical Perspectives and Their Implications for Psychopathology - Panagis, G.; Vlachou, S.; Higuera-Matas, A.; Simon, M.J. (Frontiers in Behavioral Neuroscience, 2022)

Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome - Capellan, Roberto; Orihuel, Javier; Marcos, Alberto; Ucha, Marcos; Moreno-Fernandez, Mario; Casquero-Veiga, Marta; Soto-Montenegro, Maria Luisa; Desco, Manuel; Oteo-Vives, Marta; Ibanez-Moragues, Marta; Magro-Calvo, Natalia; Morcillo, Miguel Angel; et al. (Translational Psychiatry, 2023)

Lack of interactions between prenatal immune activation and ?9-tetrahydrocannabinol exposure during adolescence in behaviours relevant to symptom dimensions of schizophrenia in rats - Moreno-Fernández, M.; Ucha, M.; Reis-de-Paiva, R.; Marcos, A.; Ambrosio, E.; Higuera-Matas, A. (Progress in neuro-psychopharmacology & biological psychiatry, 2024)

A Hidden Mark of a Troubled Past: Neuroimaging and Transcriptomic Analyses Reveal Interactive Effects of Maternal Immune Activation and Adolescent THC Exposure Suggestive of Increased Neuropsychiatric Risk - Moreno-Fernández, M.; Luján, V.; Baliyan, S.; Poza, C.; Capellán, R.; de las Heras-Martínez, N.; Morcillo, M.Á.; Oteo, M.; Ambrosio, E.; Ucha, M.; Higuera-Matas, A. (Biological Psychiatry Global Open Science, 2025)

Compulsive Coping Behavior, Developed Predominantly by Sign-Trackers, Is Exacerbated by Chronic Atomoxetine - Chernoff,C.S.; Belin-Rauscent,A.; Puaud,M.; Torrisi,S.A.; Fouyssac,M.; Németh,B.; Yu,C.; Higuera-Matas,A.; Jones,S.; Belin,D. (Biological Psychiatry, 2025)

Adolescent cannabinoid vapour exposure sex-dependently alters the relationship between vulnerability traits and ethanol self-administration and modifies naltrexone actions on ethanol intake in rats - Acosta-Vargas,J.S.; de las Heras-Martínez,N.; Marcos,A.; Nozal,L.; Crego,A.L.; Ucha,M.; Higuera-Matas,A. (Neuropharmacology, 2026)

Shared and reinforcer-specific alterations in the CRH and noradrenergic systems following short- and long-term withdrawal from cocaine, heroin, and sucrose self-administration - Roura-Martínez,D.; Ucha,M.; Moreno-Fernández,M.; Castillo,C.A.; Ballesteros-Yáñez,I.; Marcos,A.; Ambrosio,E.; Higuera-Matas,A. (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2026)