A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2 - Gimenez, Cecilio; Perez-Siles, Gonzalo; Martinez-Villarreal, Jaime; Arribas-Gonzalez, Esther; Jimenez, Esperanza; Nunez, Enrique; de Juan-Sanz, Jaime; Fernandez-Sanchez, Enrique; Garcia-Tardon, Noemi; Ibanez, Ignacio; Romanelli, Valeria; Nevado, Julian; et al. (Journal Of Biological Chemistry, 2013)

Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination - Martinez-Villarreal, Jaime; Garcia Tardon, Noemi; Ibanez, Ignacio; Gimenez, Cecilio; Zafra, Francisco (Glia, 2012)

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation - Garcia-Tardon, Noemi; Gonzalez-Gonzalez, Inmaculada M; Martinez-Villarreal, Jaime; Fernandez-Sanchez, Enrique; Gimenez, Cecilio; Zafra, Francisco (Journal Of Biological Chemistry, 2012)

Constitutive and regulated endocytosis of the glycine transporter GLYT1b is controlled by ubiquitination - Fernandez-Sanchez, Enrique; Martinez-Villarreal, Jaime; Gimenez, Cecilio; Zafra, Francisco (Journal Of Biological Chemistry, 2009)

Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids - Bustamante-Madrid, Pilar; Barbachano, Antonio; Albandea-Rodriguez, David; Rodriguez-Cobos, Javier; Rodriguez-Salas, Nuria; Prieto, Isabel; Burgos, Aurora; de Villarreal, Jaime Martinez; Real, Francisco X; Gonzalez-Sancho, Jose Manuel; Larriba, Maria Jesus; Lafarga, Miguel; et al. (Cell Death & Disease, 2024)

Combined MEK and PI3K/p110 beta Inhibition as a Novel Targeted Therapy for Malignant Mesothelioma Displaying Sarcomatoid Features - Marques, Miriam; Tranchant, Robin; Risa-Ebri, Blanca; Suarez-Solis, Maria L; Fernandez, Luis C; Carrillo-de-Santa-Pau, Enrique; Del Pozo, Natalia; Martinez de Villarreal, Jaime; Meiller, Clement; Allory, Yves; Blum, Yuna; Pirker, Christine; et al. (Cancer Research, 2020)

Urothelial organoids originating from Cd49f(high) mouse stem cells display Notch-dependent differentiation capacity - Santos, Catarina P; Lapi, Eleonora; Martinez de Villarreal, Jaime; Alvaro-Espinosa, Laura; Fernandez-Barral, Asuncion; Barbachano, Antonio; Dominguez, Orlando; Laughney, Ashley M; Megias, Diego; Munoz, Alberto; Real, Francisco X (Nature Communications, 2019)

Characterisation of the tumour microenvironment and PD-L1 granularity reveals the prognostic value of cancer-associated myofibroblasts in non-invasive bladder cancer - Canizo, Carmen G; Guerrero-Ramos, Felix; Perez Escavy, Mercedes; Lodewijk, Iris; Suarez-Cabrera, Cristian; Morales, Lucia; Nunes, Sandra P; Munera-Maravilla, Ester; Rubio, Carolina; Sanchez, Rebeca; Rodriguez-Izquierdo, Marta; Martinez de Villarreal, Jaime; et al. (ONCOIMMUNOLOGY, 2025)

A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice - Bodas, Cristina; Felipe, Irene; Chanez, Brice; Lafarga, Miguel; Lopez de Maturana, Evangelina; Martinez de Villarreal, Jaime; del Pozo, Natalia; Malumbres, Marina; Vargiu, Pierfrancesco; Cayuela, Ana; Peset, Isabel; Connelly, Katelyn; et al. (GUT, 2025)

NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation - Cobo, Isidoro; Paliwal, Sumit; Bodas, Cristina; Felipe, Irene; Melia-Aloma, Julia; Torres, Ariadna; Martinez-Villarreal, Jaime; Malumbres, Marina; Garcia, Fernando; Millan, Irene; del Pozo, Natalia; Park, Joo-Cheol; et al. (NATURE COMMUNICATIONS, 2023)

Tumor and Stromal Cell Targeting with Nintedanib and Alpelisib Overcomes Intrinsic Bladder Cancer Resistance - Marques, Miriam; Corral, Sonia; Sanchez-Diaz, Maria; del Pozo, Natalia; Martinez de Villarreal, Jaime; Schweifer, Norbert; Zagorac, Ivana; Hilberg, Frank; Real, Francisco X (MOLECULAR CANCER THERAPEUTICS, 2023)

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma - de Andres, Monica P; Jackson, Richard J; Felipe, Irene; Zagorac, Sladjana; Pilarsky, Christian; Schlitter, Anna Melissa; Martinez de Villareal, Jaime; Jang, Gun Ho; Costello, Eithne; Gallinger, Steve; Ghaneh, Paula; Greenhalf, William; et al. (GUT, 2023)

Pseudoalignment tools as an efficient alternative to detect repeated transposable elements in scRNAseq data - Martinez de Villarreal, Jaime; Kalisz, Mark; Piedrafita, Gabriel; Grana-Castro, Osvaldo; Chondronasiou, Dafni; Serrano, Manuel; Real, Francisco X (BIOINFORMATICS, 2023)

Deciphering the roadmap of in vivo reprogramming toward pluripotency - Chondronasiou, Dafni; de Villarreal, Jaime Martinez; Melendez, Elena; Lynch, Cian J; del Pozo, Natalia; Kovatcheva, Marta; Aguilera, Monica; Prats, Neus; Real, Francisco X; Serrano, Manuel (STEM CELL REPORTS, 2022)

Natural killer cells act as an extrinsic barrier for in vivo reprogramming - Melendez, Elena; Chondronasiou, Dafni; Mosteiro, Lluc; Martinez de Villarreal, Jaime; Fernandez-Alfara, Marcos; Lynch, Cian J; Grimm, Dirk; Real, Francisco X; Alcami, Jose; Climent, Nuria; Pietrocola, Federico; Serrano, Manuel (DEVELOPMENT, 2022)

A GATA6-centred gene regulatory network involving HNFs and ?Np63 controls plasticity and immune escape in pancreatic cancer - Kloesch, Bernhard; Ionasz, Vivien; Paliwal, Sumit; Hruschka, Natascha; Martinez de Villarreal, Jaime; Ollinger, Rupert; Mueller, Sebastian; Dienes, Hans Peter; Schindl, Martin; Gruber, Elisabeth S; Stift, Judith; Herndler-Brandstetter, Dietmar; et al. (GUT, 2022)

Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors - Garcia-Carbonero, Rocio; Bazan-Peregrino, Miriam; Gil-Martin, Marta; Alvarez, Rafael; Macarulla, Teresa; Riesco-Martinez, Maria C; Verdaguer, Helena; Guillen-Ponce, Carmen; Farrera-Sal, Marti; Moreno, Rafael; Mato-Berciano, Ana; Victoria Maliandi, Maria; et al. (JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022)

Discovery and 3D imaging of a novel ?Np63-expressing basal cell type in human pancreatic ducts with implications in disease - Martens, Sandrina; Coolens, Katarina; Van Bulck, Mathias; Arsenijevic, Tatjana; Casamitjana, Joan; Ruiz, Angel Fernandez; El Kaoutari, Abdessamad; de Villareal, Jaime Martinez; Madhloum, Hediel; Esni, Farzad; Heremans, Yves; Leuckx, Gunter; et al. (GUT, 2021)

Secondary resistance to anti-EGFR therapy by transcriptional reprogramming in patient-derived colorectal cancer models - Vangala, Deepak; Ladigan, Swetlana; Liffers, Sven T; Noseir, Soha; Maghnouj, Abdelouahid; Gotze, Tina-Maria; Verdoodt, Berlinda; Klein-Scory, Susanne; Godfrey, Laura; Zowada, Martina K; Huerta, Mario; Edelstein, Daniel L; et al. (GENOME MEDICINE, 2021)

Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice - Caceres, Marta; Quesada, Rita; Iglesias, Mar; Real, Francisco X; Villamonte, Maria; Martinez de Villarreal, Jaime; Perez, Monica; Andaluz, Ana; Moll, Xavier; Berjano, Enrique; Dorcaratto, Dimitri; Sanchez Velazquez, Patricia; et al. (SCIENTIFIC REPORTS, 2020)

Contribution of BRCA1 and BRCA2 germline mutations to early onset breast cancer: a series from north of Morocco - Bakkach, Joaira; Mansouri, Mohamed; Derkaoui, Touria; Loudiyi, Ali; El Fahime, ElMostafa; Barakat, Amina; Ghailani Nourouti, Naima; Martinez De Villarreal, Jaime; Cortijo Bringas, Carlos; Bennani Mechita, Mohcine (BMC CANCER, 2020)

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury - Engel, Tobías; Martinez-Villarreal, Jaime; Henke, Christine; Jimenez-Mateos, Eva M; Sanz-Rodriguez, Amaya; Alves, Mariana; Hernandez-Santana, Yasmina; Brennan, Gary P; Kenny, Aidan; Campbell, Aoife; Lucas, José J; Henshall, David C (Molecular Neurodegeneration, 2017)

Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death - Moran, C; Sanz-Rodriguez, A; Jimenez-Pacheco, A; Martinez-Villareal, J; McKiernan, R C; Jimenez-Mateos, E M; Mooney, C; Woods, I; Prehn, J H M; Henshall, D C; Engel, T (CELL DEATH & DISEASE, 2013)

Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain - Caballero-Caballero, Aurelien; Engel, Tobias; Martinez-Villarreal, Jaime; Sanz-Rodriguez, Amaya; Chang, Patrick; Dunleavy, Mark; Mooney, Claire M; Jimenez-Mateos, Eva M; Schindler, Clara K; Henshall, David C (JOURNAL OF NEUROCHEMISTRY, 2013)