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Author profile at the institutional portal

Garcia Yague, Angel Juan angelj.garcia@uam.es

Bioquímica / Universidad Autónoma de Madrid

Publications

Repurposing the NRF2 activator dimethyl fumarate as therapy against synucleinopathy in Parkinson's disease

  • Lastres-Becker, Isabel
  • Garcia-Yague, Angel J
  • Scannevin, Robert H
  • Casarejos, Maria J
  • Kuegler, Sebastian
  • Rabano, Alberto
  • Cuadrado, Antonio
... View more Collapse

Antioxidants & Redox Signaling (p. 61-77) - 10/7/2016

10.1089/ars.2015.6549 View at source

  • ISSN 15230864

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

  • Pajares, Marta
  • Jimenez-Moreno, Natalia
  • Garcia-Yague, Angel J
  • Escoll, Maribel
  • de Ceballos, Maria L
  • Van Leuven, Fred
  • Rabano, Alberto
  • Yamamoto, Masayuki
  • Rojo, Ana I
  • Cuadrado, Antonio
... View more Collapse

Autophagy (p. 1902-1916) - 2/10/2016

10.1080/15548627.2016.1208889 View at source

  • ISSN 15548627

Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells

  • Galan-Ganga, Marcos
  • Garcia-Yague, Angel J
  • Lastres-Becker, Isabel

Cellular And Molecular Neurobiology (p. 331-340) - 15/4/2019

10.1007/s10571-019-00664-w View at source

  • ISSN 02724340

Effect of Nrf2 deletion in cardiovascular alterations associated to Ang II-induced hypertension

  • Casales, MM
  • Hernanz, R
  • González-Carnicero, Z
  • Barrús, MT
  • Martín, A
  • Briones, AM
  • García-Yagüe, AJ
  • Cuadrado, A
  • Alonso, MJ
  • Ramchandani, B
  • Celis, AFD
  • López-Andrés, N
  • Cachofeiro, V
... View more Collapse

Clinical Science - 1/3/2023

  • ISSN 01435221
  • iMarina

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

  • Herrera-Arozamena, Clara
  • Estrada-Valencia, Martin
  • Perez, Concepcion
  • Lagartera, Laura
  • Morales-Garcia, Jose A
  • Perez-Castillo, Ana
  • Felipe Franco-Gonzalez, Juan
  • Michaiska, Patrycja
  • Duarte, Pablo
  • Leon, Rafael
  • Lopez, Manuela G
  • Mills, Alberto
  • Gago, Federico
  • Juan Garcia-Yague, Angel
  • Fernandez-Gines, Raquel
  • Cuadrado, Antonio
  • Isabel Rodriguez-Franco, Maria
... View more Collapse

European Journal Of Medicinal Chemistry - 15/3/2020

Editor: Elsevier Masson s.r.l.

10.1016/j.ejmech.2020.112090 View at source

  • ISSN 02235234
  • ISSN/ISBN 1768-3254

Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2

  • Garcia-Yague, Angel J
  • Cueto-Diaz, Eduardo J
  • Escoll, Maribel
  • Okunishi, Isao
  • Hayes, John D
  • Rodriguez-Franco, Maria Isabel
  • Rojo, Ana I
  • Cuadrado, Antonio
... View more Collapse

FREE RADICAL BIOLOGY AND MEDICINE (p. 579-593) - 25/11/2025

10.1016/j.freeradbiomed.2025.07.051 View at source

  • ISSN 08915849

Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier

  • Cazalla, Eduardo
  • Cuadrado, Antonio
  • Garcia-Yague, Angel Juan

Fluids and Barriers of the CNS - 21/11/2024

10.1186/s12987-024-00599-5 View at source

  • ISSN 20458118

Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.

  • Castro-Sanchez, Sara
  • Garcia-Yaguee, Angel J
  • Lopez-Royo, Tresa
  • Casarejos, Maria
  • Luis Lanciego, Jose
  • Lastres-Becker, Isabel

Glia (p. 1752-1762) - 1/8/2018

10.1002/glia.23338 View at source

  • ISSN 08941491

Modulation of the Receptor Tyrosine Kinase TIE2/Tek Pathway by NRF2 Activation in Neurovascular Endothelial Cells

  • Cazalla, Eduardo
  • Garcia-Yague, Angel Juan
  • Pajares, Marta
  • Jimenez-Villegas, Jose
  • Escoll, Maribel
  • Rojo, Ana I
  • Rojo, Ana I
  • Cuadrado, Antonio
... View more Collapse

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 13/1/2026

10.3390/ijms27020770 View at source

  • ISSN 14220067

Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology

  • Garcia-Yague, Angel Juan
  • Cuadrado, Antonio

International Journal Of Molecular Sciences - 1/8/2023

10.3390/ijms241512280 View at source

  • ISSN 14220067

This researcher has no books.

This researcher has no book chapters.

A0n alternative for reducing the layers in the construction of three-phase planar transformers

  • Prieto, R
  • Asensi, R
  • Garcia, O
  • Cobos, J A
  • Jerez, F
  • Gerez, F

Conference Proceedings - Ieee Applied Power Electronics Conference And Exposition - Apec (p. 1023-1026) - 30/4/2012

10.1109/apec.2012.6165944 View at source

  • ISSN 10482334

THERAPEUTIC TARGETING THE NRF2/BETA-TRCP COMPLEX IN METABOLIC-ASSOCIATED FATTY LIVER DISEASE (MAFLD)

  • Fernandez-Gines, Raquel
  • Antonio Encinar, Jose
  • Garcia-Yague, Angel J
  • Rojo, Ana I
  • Cuadrado, Antonio

FREE RADICAL BIOLOGY AND MEDICINE (p. 53-53) - 3/6/2024

10.1016/j.freeradbiomed.2024.04.189 View at source

  • ISSN 08915849

IDENTIFICATION OF THE NRF2/β-TRCP AXIS TO PROTECT AGAINST NON-ALCOHOLIC STEATOHEPATITIS.

  • Fernandez-Gines, Raquel
  • Miguez, Raquel
  • Antonio Encinar, Jose
  • Escoll, Maribel
  • Carnicero-Senabre, Daniel
  • Jimenez-Villegas, Jose
  • Garcia-Yague, Angel J
  • Rojo, Ana I
  • Cuadrado, Antonio
... View more Collapse

FREE RADICAL BIOLOGY AND MEDICINE (p. 15-15) - 3/6/2024

10.1016/j.freeradbiomed.2024.04.058 View at source

  • ISSN 08915849

Regulation of the extracellular matrix glycoprotein Reelin by the transcription factor NRF2: A protective mechanism for the brain under oxidative stress

  • Garcia-Yague, Angel J
  • Cuadrado, Antonio

Free Radical Biology And Medicine (p. NULL-48) - 1/1/2021

10.1016/j.freeradbiomed.2020.12.398 View at source

  • ISSN 08915849

TRANSCRIPTION FACTOR NRF2 REGULATES THE PERMEABILITY OF THE BLOOD BRAIN BARRIER AT THE LEVEL OF ANGPT1/2-TIE2 SIGNALING

  • Cazalla, Eduardo
  • Garcia-Yague, Angel J
  • Pajares, Marta
  • Jimenez-Villegas, Jose
  • Cuadrado, Antonio

Free Radical Biology And Medicine (p. 16-17) - 20/5/2023

10.1016/j.freeradbiomed.2023.03.083 View at source

  • ISSN 08915849

New therapeutic strategies in Parkinson's disease: the transcription factor NRF2 as a target for dimethyl fumarate

  • Lastres-Becker, I
  • Garcia-Yaguee, A
  • Troya-Balseca, J
  • Kuegler, S
  • Cuadrado, A

Journal Of Neurochemistry (p. 280-280) - 1/1/2015

  • ISSN 00223042
  • iMarina

Impact of the transcription factor NRF2 on tau and beta-amyloid pathology in a combined mouse model of Alzheimer's disease

  • Pajares, M
  • Rada, P
  • Garcia-Yague, A J
  • Cuadrado, A
  • Rojo, A I

Journal Of Neurochemistry (p. 327-327) - 1/8/2015

  • ISSN 00223042
  • iMarina

This researcher has no working papers.

This researcher has no technical reports.

DESARROLLO DE NUEVOS FÁRMACOS ANTI-INFLAMATORIOS BASADOS EN LA ACTIVACIÓN DEL FACTOR DE TRANSCRIPCIÓN NRF2

  • FERNANDEZ GINES, RAQUEL (Miembro del equipo de trabajo)
  • GARCIA YAGUE, ANGEL JUAN (Miembro del equipo de trabajo)
  • Rojo Sanchís, Ana Isabel (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 01-12-2021 - 30-11-2023

Type of funding: National

Amount of funding: 149500,00 Euros.

  • iMarina

El factor de transcripción nrf2 en la patofisiología de la enfermedad de Alzheimer

  • Pajares Cabetas, Marta (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • FERNANDEZ GINES, RAQUEL (Investigador/a)
  • LASTRA MARTINEZ, DIEGO (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
  • Robledinos Anton, Natalia (Investigador/a)
  • Escoll Guerrero, Maria Isabel (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador principal (IP))
... View more Collapse

Period: 01-06-2020 - 31-05-2023

Type of funding: National

Amount of funding: 369050,00 Euros.

  • iMarina

Desarrollo de fármacos activadores de NRF2 para terapias innovadoras de la enfermedad de alzheimer

  • NATALIA ROBLEDINOS ANTON (Miembro del equipo de investigación)
  • MARIA ISABEL ESCOLL GUERRERO (Miembro del equipo de investigación)
  • Ana Isabel Rojo Sanchis (Miembro del equipo de investigación)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
  • Pajares Cabetas, Marta (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • Robledinos Anton, Natalia (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador/a)
  • Garcia Lopez, Manuela (Investigador principal (IP))
  • MARTA PAJARES CABETAS (Miembro del equipo de investigación)
  • Angel Juan Garcia Yague (Miembro del equipo de investigación)
... View more Collapse

Period: 01-01-2018 - 31-12-2021

Amount of funding: 95091,66 Euros.

  • iMarina

PAPEL DE NRF2 COMO MODULADOR ANTIOXIDANTE DE LA NEUROINFLAMACION EN LA ENFERMEDAD DE ALZHEIMER

  • Rada Llano, Patricia Pilar (Investigador/a)
  • Ana Isabel Rojo Sanchis (Investigador/a)
  • Lastres Becker, Isabel (Investigador/a)
  • Angel Juan Garcia Yague (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
... View more Collapse

Period: 01-01-2014 - 31-12-2016

  • iMarina

PAPEL DEL FACTOR DE TRANSCRIPCIÓN NRF2 EN PROTECCIÓN SINÁPTICA EN LAS TAUOPATÍAS

  • FERNANDEZ GINES, RAQUEL (Investigador/a)
  • JIMENEZ VILLEGAS, JOSE (Investigador/a)
  • CARNICERO SENABRE, DANIEL (Investigador/a)
  • Escoll Guerrero, Maria Isabel (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • CAZALLA IBAÑEZ, EDUARDO (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador principal (IP))
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
... View more Collapse

Period: 01-09-2023 - 31-08-2026

Type of funding: National

Amount of funding: 375000,00 Euros.

  • iMarina

OPTIMIZACIÓN DE UN NUEVO ACTIVADOR DEL FACTOR DE TRANSCRIPCIÓN NRF2 PARA FRENAR LA PROGRESIÓN DE NASH

  • FERNANDEZ GINES, RAQUEL (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador principal (IP))
  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 01-12-2022 - 30-11-2024

Type of funding: National

Amount of funding: 149500,00 Euros.

  • iMarina

DESARROLLO DE FARMACOS ACTIVADORES DE NRF2 PARA TERAPIAS INNOVADORAS DE LA ENFERMEDAD DE ALZHEIMER - GT2

  • Cuadrado Pastor, Antonio (Investigador principal (IP))
  • Pajares Cabetas, Marta (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • Robledinos Anton, Natalia (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador/a)
  • Garcia Lopez, Manuela (Investigador principal (IP))
  • Escoll Guerrero, Maria Isabel (Investigador/a)
... View more Collapse

Period: 01-01-2018 - 30-06-2022

  • iMarina

Regulación del factor de trascripción Nurr1 mediante cambios en su localización subcelular y su estabilidad por estrés oxidativo

  • Cuadrado Pastor, Antonio (Director) Doctorando: García Yagüe, Ángel

1/1/2012

  • iMarina

This researcher has no patents or software licenses.

Last data update: 2/15/26 11:43 PM