AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease - Pardo B; Herrada-Soler E; Satrústegui J; Contreras L; Del Arco A (International Journal Of Molecular Sciences, 2022)

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition - Esparza-Moltó PB; Romero-Carramiñana I; de Arenas CN; Pereira MP; Blanco N; Pardo B; Bates GR; Sánchez-Castillo C; Artuch R; Murphy MP; Esteban JA; Cuezva JM (Plos Biology, 2021)

Î²OHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet - Pérez-Liébana I; Casarejos MJ; Alcaide A; Herrada-Soler E; Llorente-Folch I; Contreras L; Satrústegui J; Pardo B (Journal Of Neuroscience, 2020)

The mitochondrial aspartate-glutamate carrier Aralar/AGC1 controls neuronal respiration and (beta)-Hydroxybutyrate rescues brain defects caused by AGC1 deficiency - Satrustegui Gil Delgado, Jorgina (Director); Pardo Merino, Beatriz (Director) Doctorando: Pérez Liébana, Irene (2020)

Mitochondrial movement in Aralar/Slc25a12/AGC1 deficient cortical neurons - Puertas-Frías G, Del Arco A, Pardo B, Satrústegui J, Contreras L (Neurochemistry International, 2019)

The Response to Stimulation in Neurons and Astrocytes - Juaristi I., Contreras L., González-Sánchez P., Pérez-Liébana I., González-Moreno L., Pardo B., del Arco A., Satrústegui J. (Neurochemical Research, 2019)

Transportadores mitocondriales regulados por CA2: papel de ARALAR/AGC1 en regulación metabólica y trafico intercelular y papel de scamc1 en el metabolismo tumoral - del Arco Martínez, Araceli (Investigador/a); Satrustegui Gil Delgado, Jorgina (Investigador/a); Pardo Merino, Beatriz (Investigador principal (IP)) (2018)

ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate - Juaristi I., García-Martín M.L., Rodrigues T.B., Satrústegui J., Llorente-Folch I., Pardo B. (Journal Of Neurochemistry, 2017)

Calcium regulation of mitochondrial carriers - Del Arco A, Contreras L, Pardo B, Satrustegui J (Biochimica Et Biophysica Acta-Molecular Cell Research, 2016)

Glutamate excitotoxicity and Ca-regulation of respiration: Role of the Ca activated mitochondrial transporters (CaMCs) - Rueda CB, Llorente-Folch I, Traba J, Amigo I, Gonzalez-Sanchez P, Contreras L, Juaristi I, Martinez-Valero P, Pardo B, Del Arco A, Satrustegui J (Biochimica Et Biophysica Acta-Bioenergetics, 2016)

L-lactate-mediated neuroprotection against glutamate- induced excitotoxicity requires ARALAR/AGC1 - Llorente-Folch I., Rueda C.B., Pérez-Liébana I., Satrústegui J., Pardo B. (Journal Of Neuroscience, 2016)

The regulation of neuronal mitochondrial metabolism by calcium - Llorente-Folch, I.; Rueda, C. B.; Pardo, B.; Szabadkai, G.; Duchen, M. R.; Satrustegui, J.; (Journal Of Physiology-London, 2015)

Señalización por calcio a la mitocondria y regulación metabólica en neuronas y glía: implicaciones terapéuticas - Pardo Merino, Beatriz (Investigador principal (IP)); Satrustegui Gil Delgado, Jorgina (Investigador principal (IP)) (2015)

Mitochondrial ATP-Mg/pi carrier SCaMC-3/Slc25a23 counteracts PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons - Rueda XB; Traba J; Amigo I; Llorente-Folch I; González-Sánchez P; Pardo B; Esteban JA; Del Arco A; Satrústegui J (Journal Of Neuroscience, 2015)

Señalización por calcio a la mitocondria a través de CaMC - Satrustegui Gil Delgado, Jorgina (Codirector); Pardo Merino, Beatriz (Codirector) Doctorando: Rueda Díez, Carlos B. (2014)

Ca2 + regulation of mitochondrial function in neurons - Rueda C; Llorente-Folch I; Amigo I; Contreras L; González-Sánchez P; Martínez-Valero P; Juaristi I; Pardo B; Del Arco A; Satrústegui J (Biochimica Et Biophysica Acta-Bioenergetics, 2014)

Calcium modulation of mitochondrial function under physiological and pathological stimulation: Role of the atp-mg/pi carrier, scamc-3 - Cuezva Marcos, Jose Manuel (Autor o Coautor); Diaz Nido, Javier (Autor o Coautor); Satrustegui Gil Delgado, Jorgina (Autor o Coautor); Jorgina Satrústegui Gil-Delgado (Director); Beatriz Pardo Merino (Director); Araceli del Arco Martinez (Director) Doctorando: Carlos B Rueda Díez (2014)

Calcium-regulation of mitochondrial respiration maintains ATP homeostasis and requires ARALAR/AGC1-malate aspartate shuttle in intact cortical neurons - Llorente-Folch I; Rueda CB; Amigo I; del Arco A; Saheki T; Pardo B; Satrústegui J (Journal Of Neuroscience, 2013)

New roles of Aralar/AGC1, the brain mitocondrial aspartate-glutamate carrier, in dopamine handling, glutamate excitotoxicity and regulation of mitochondrial respiration - Martinez Serrano, Alberto (Autor o Coautor); Satrustegui Gil Delgado, Jorgina (Autor o Coautor); Aragon Rueda, Carmen (Autor o Coautor); Jorgina Satrústegui Gil-Delgado (Director); Beatriz Pardo Merino (Director) Doctorando: Irene Llorente Folch (2013)

AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway - Llorente-Folch I; Sahún I; Contreras L; Casarejos MJ; Grau JM; Saheki T; Mena MA; Satrústegui J; Dierssen M; Pardo B (Journal Of Neurochemistry, 2013)

Altered postnatal development of cortico-hippocampal neuronal electric activity in mice deficient for the mitochondrial aspartate-glutamate transporter - Satrustegui Gil Delgado, Jorgina; Pardo Merino, Beatriz; Gomez-Galan, Marta; Makarova, Julia; Llorente-Folch, Irene; Saheki, Takeyori; Herrerasi, Oscar (Journal Of Cerebral Blood Flow And Metabolism, 2012)

Role of the Ca2+ uniporter and the mitochondrial Ca2+-activatedtransporters of aspartate/glutamate (aralar/AGC1) and ATP-Mg/Pi(SCaMC-3) in agonist-stimulated respiration of intact cerebral cortexneurons - Rueda, Carlos B.; Llorente-Folch, Irene; Traba, Javier; Amigo, Ignacio; del Arco, Araceli; Pardo, Beatriz; Satrustegui, Jorgina; (Biochimica Et Biophysica Acta-Bioenergetics, 2012)

Deficiency of the mitochondrial transporter of aspartate/glutamate aralar/AGC1 causes hypomyelination and neuronal defects unrelated to myelin deficits in mouse brain - Ramos M., Pardo B., Llorente-Folch I., Saheki T., del Arco A., Satrústegui J. (Journal Of Neuroscience Research, 2011)

Calcium Signaling in Neuronal Mitochondria - Satrustegui, Jorgina; Llorente-Folch, Irene; Contreras, Laura; Marmol, Patricia; Cavero, Santiago; Traba, Javier; Amigo, Ignacio; Rueda, Carlos; Del Arco, Araceli; Pardo, Beatriz; (Journal Of General Physiology, 2011)

Brain glutamine synthesis requires neuronal-born aspartate as amino donor for glial glutamate formation - Pardo B; Rodrigues TB; Contreras L; Garzón M; Llorente-Folch I; Kobayashi K; Saheki T; Cerdan S; Satrüstegui J (Journal Of Cerebral Blood Flow And Metabolism, 2011)

Implicación de aralar/AGC1/Slc25a12, el transportador mitocondrial de aspartato-guclamato, y su dependencia funcional - Pardo Merino, Beatriz (Director); Satrustegui Gil Delgado, Jorgina (Director); Patricia Marmol Carrasco (Director) Doctorando: Marmol Carrasco, Patricia (2009)

Requirement for Aralar and Its Ca2+-binding Sites in Ca2+ Signal Transduction in Mitochondria from INS-1 Clonal beta-Cells - Marmol, Patricia; Pardo, Beatriz; Wiederkehr, Andreas; del Arco, Araceli; Wollheim, Claes B.; Satrustegui, Jorgina; (Journal Of Biological Chemistry, 2009)

Papel de aralar, el transportador mitocondrial de aspartato-glutamato, y su regulación por calcio en el metabolismo cerebral y en el tráfico metabólico intercelular in vivo. - TRABA DOMINGUEZ, JAVIER (Investigador/a); Patricia Marmol Carrasco (Investigador/a); Amigo de la Huerga, Ignacio (Investigador/a); Llorente Folch, Irene (Investigador/a); Rueda Diez, Carlos (Investigador/a); Laura Contreras Balsa (Investigador/a); Traba Diaz, Juan (Investigador/a); Pardo Merino, Beatriz (Investigador/a); Barbara Sese Cobos (Investigador/a); Satrustegui Gil Delgado, Jorgina (Investigador principal (IP)) (2009)

Implicacion de aralar/agc1/sic25a12,el transportador mitocondrial de aspartato-glutamato, y su dependencia funcional de ca2+ en el metabolismo de la glucosa responsable de la secreción de insulina en la celula-b - Cuezva Marcos, Jose Manuel (Autor o Coautor); Garcia Ruiz, Predestinacion (Autor o Coautor); Satrustegui Gil Delgado, Jorgina (Autor o Coautor); Beatriz Pardo Merino (Director); Jorgina Satrústegui Gil-Delgado (Director) Doctorando: Patricia Marmol Carrasco (2009)

Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca2+ signaling in neuronal mitochondria - Satrústegui J., Contreras L., Ramos M., Marmol P., Del Arco A., Saheki T., Pardo B. (Journal Of Neuroscience Research, 2007)

Mitochondrial transporters as novel targets for intracellular calcium signaling - Satrustegui, Jorgina; Pardo, Beatriz; Del Arco, Araceli; (Physiological Reviews, 2007)

Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria - Satrustegui Gil Delgado, Jorgina; Pardo Merino, Beatriz; Contreras, Laura; Serrano, Antonio; Ramos, Milagros; Kobayashi, Keiko; Iijima, Mikio; Saheki, Takeyori (Journal Of Biological Chemistry, 2006)

Funciones de los transportadores mitocondriales dependientes de calcio: los transportadores de aspartato-glutamato (AGCS) y de ATP-MG/PI (SCAMCS O APCS) - Patricia Marmol Carrasco (Investigador/a); Javier Traba Dominguez (Investigador/a); Laura Contreras Balsa (Investigador/a); Pardo Merino, Beatriz (Investigador/a); Barbara Sese Cobos (Investigador/a); Satrustegui Gil Delgado, Jorgina (Investigador principal (IP)) (2005)

Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier - Jalil M.A., Begumi L., Contreras L., Pardo B., Iijima M., Li M.X., Ramos M., Marmol P., Horiuchi M., Shimotsu K., Nakagawa S., Okubo A., Sameshima M., Isashiki Y., Del Arco A., Kobayashi K., Satrústegui J., Saheki T. (Journal Of Biological Chemistry, 2005)

Papel de la mitocondria en la muerte neuronal: estudio de la implicación de aralar y la lanzadera Nadh Malato-Aspartato en la susceptibilidad a la muerte neuronal. - Patricia Marmol Carrasco (Investigador/a); Pardo Merino, Beatriz (Investigador/a); Araceli del Arco Martinez (Investigador/a); Satrustegui Gil Delgado, Jorgina (Investigador principal (IP)) (2005)

Developmental changes in the Ca2+ -regulated mitochondrial aspartate-glutamate carrier aralar1 in brain and prominent expression in the spinal cord - Satrustegui Gil Delgado, Jorgina; Pardo Merino, Beatriz; Martinez Serrano, Alberto; Bogonez Pelaez, Elena; Ramos, M; del Arco, A; Martinez-Serrano, A; Martinez-Morales, JR; Kobayashi, K; Yasuda, T; Bovolenta, P; Saheki, T (Developmental Brain Research, 2003)

Citrin and aralar1 are Ca2+-stimulated aspartate/glutamate transporters in mitochondria - Palmieri, L; Pardo, B; Lasorsa, FM; del Arco, A; Kobayashi, K; Iijima, M; Runswick, MJ; Walker, JE; Saheki, T; Satrustegui, J; Palmieri, F; (Embo Journal, 2001)

Transportadores mitocondriales regulados por calcio: papel de SCAMC3 y CITRIN en la señalización por calcio en el hígado y de aralar en la comunicación intercelular en el SNC - HERRADA SOLER, EDUARDO (Investigador/a); Arco Martínez, Araceli del (Investigador/a); SESE COBOS, BARBARA (Investigador/a); Araceli del Arco Martinez (Investigador principal (IP)); Juaristi Santos, Ines (Investigador/a); Pardo Merino, Beatriz (Investigador principal (IP)) (2021)

Puesta a punto de un algoritmo molecular diagnóstico en pacientes con ELA y/o DFT - Garci?a Redondo, Alberto (Director); Pardo Merino, Beatriz (Tutor) Doctorando: Borrego Hernández, Daniel (2020)

The effects of p27Kip1 on the in vivo development and in vitro differentiation of mesencephalic dopaminergic neurons - Pardo Merino, Beatriz (Autor o Coautor); Liste Noya, Isabel (Director) (2020)

The metabolism of diacylglycerol in T cell tolerance regulation and tumor evasion - Me?rida de San Roma?n, Isabel (Director); Ávila Flores, Juana Antonia (Director); Pardo Merino, Beatriz (Tutor) Doctorando: Arranz Nicolás, Javier (2019)

Mitochondrial OxPhos: the integrador of the cellular metabolic status - (Director); Ruiz-Cabello Osuna, Jesus Maria (Director); Enriquez Dominguez, Jose Antonio (Director); Pardo Merino, Beatriz (Tutor) Doctorando: Ana Victoria Lechuga Vieco (2018)

Fabrication and characterisation of a micropattern-based platform to model epithelial tubulogenesis and to perform nephrotoxicity assays - Fernando Martín Belmonte (Director); Pardo Merino, Beatriz (Tutor) Doctorando: Minerva Bosch Fortea (2018)

Generation and differentiation of dopaminergic neurons from mouse multipotent and human induced pluripotent stem cells to study parkinson?s disease - Pardo Merino, Beatriz (Tutor) (2017)

De novo Synthesis of Glial Glutamate and Glutamine in Young Mice Requires Aspartate Provided by the Neuronal Mitochondrial Aspartate-Glutamate Carrier Aralar/AGC1 - Pardo B, Contreras L, Satrústegui J (Frontiers In Endocrinology, 2013)

Aralar como gen candidato en autismo implicado en la lanzadera de lactato astrocito-neurona. Activación de la vía aralar-MAS en neuronas por señales pequeñas de calcio - Pardo Merino, Beatriz (Investigador principal (IP)) (2007)

Aggregating brain cell cultures: investigation of stroke related brain damage - Honegger, Paul; Pardo, Beatriz; (Altex : Alternativen Zu Tierexperimenten, 2007)

Transportadores mitocondriales regulados por calcio y su implicación en patología mitocondrial - Pardo Merino, Beatriz (Investigador/a) (2006)

Emergence of oriented cell assemblies associated with spike-timing-dependent plasticity - Iglesias, J; Eriksson, J; Pardo, B; Tomassini, M; Villa, AEP; (Lecture Notes In Computer Science, 2005)

Stimulus-driven unsupervised synaptic pruning in large neural networks - Iglesias, J; Eriksson, J; Pardo, B; Tomassini, M; Villa, AEP; (Lecture Notes In Computer Science, 2005)

Cross-channel coupling of neuronal activity in parvalbumin-deficient mice susceptible to epileptic seizures - Villa, AEP; Asai, Y; Tetko, IV; Pardo, B; Celio, MR; Schwaller, B; (Epilepsia, 2005)

Estudio de la activación por calcio de la lanzadera aspartato-malato y su papel en la muerte neuronal por amiloíde mediante células troncales neurales deficientes en Aralar1 - Pardo Merino, Beatriz (Investigador/a) (2004)

Estudio de la activación por calcio de la lanzadera de NADH aspartato-malato y su papel en la señalización mitocondrial - Pardo Merino, Beatriz (Investigador/a) (2003)

Alteration of amino acid metabolism in neuronal aggregate cultures exposed to hypoglycaemic conditions - Honegger P, Braissant O, Henry H, Boulat O, Bachmann C, Zurich MG, Pardo B (Journal Of Neurochemistry, 2002)

Estudios funcionales de aralar1: activación por calcio de la lanzadera de NADH aspartato-malato y papel en la supervivencia neuronal en modelos celulares y animales - Pardo Merino, Beatriz (Investigador/a) (2002)

Estudios del gen aralar1, homólogo al gen citrina/aralar2 causante de la citrulinemia de tipo II, como posible responsable de enfermedades humanas del cromosoma 2q24-2q31 - Pardo Merino, Beatriz (Investigador/a) (2001)

Differentiation of rat striatal embryonic stem cells in vitro: Monolayer culture vs. three-dimensional coculture with differentiated brain cells - Pardo B, Honegger P (Journal Of Neuroscience Research, 2000)

Evaluation of aggregating brain cell cultures as a model for studying ischaemia-related neurodegenerative processes - Pardo, B; Honegger, P; (Progress In The Reduction, Refinement And Replacement Of Animal Experimentation, 2000)

Aggregating brain cell cultures as a model to study ischaemia-induced neurodegeneration - Pardo B, Honegger P (Toxicology In Vitro, 1999)

High sensitivity of immature GABAergic neurons to blockers of voltage- gated calcium channels - Pardo B, Honegger P (Developmental Brain Research, 1999)

Selective neurodegeneration induced in rotation-mediated aggregate cell cultures by a transient switch to stationary culture conditions: A potential model to study ischemia-related pathogenic mechanisms - Pardo B, Honegger P (Brain Research, 1999)

Separate neuronal and glial Na+,K+-ATPase isoforms regulate glucose utilization in response to membrane depolarization and elevated extracellular potassium - Honegger P, Pardo B (Journal Of Cerebral Blood Flow And Metabolism, 1999)

Caracterización funcional de Aralar, un gen humano que pertenece a una nueva subfamilia de transportadores mitocondriales dependientes de calcio. Clonaje y caracterización de genes homólogos - Pardo Merino, Beatriz (Investigador/a) (1999)

Muscimol-induced death of GABAergic neurons in rat brain aggregating cell cultures - Honegger P, Pardo B, Monnet-Tschudi F (Developmental Brain Research, 1998)

Hyperpolarization-induced death of immature inhibitory neurons - Pardo, B; Monnet-Tschudi, F; Honegger, P; (Pflugers Archiv-European Journal Of Physiology, 1998)

Neuronal-enriched cultures from embryonic rat ventral mesencephalon for pharmacological studies of dopamine neurons - Pardo B, Paíno CL, Casarejos MJ, Mena MA (Brain Research Protocols, 1997)

Use of a three-dimensional brain cell culture system as a model for ischemia research - Pardo Merino, Beatriz (Investigador/a) (1997)

Changes Induced by Ovariectomy on the Acute Effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a Model of Rat Poor Metabolizer of Debrisoquine - Jiménez-Jiménez FJ, Mena MA, García-Agúndez J, Tabernero C, Pardo B, Carazo A, Benítez J, García-Ruiz PJ, Yébenes JG (Parkinsonism & Related Disorders, 1996)

Evaluation of the teratogenic and neurodegenerative potential of enviromental pollulants - Pardo Merino, Beatriz (Investigador/a) (1996)

Toxic effects of L-DOPA on mesencephalic cell cultures: Protection with antioxidants - Pardo B, Mena MA, Casarejos MJ, Paíno CL, De Yébenes JG (Brain Research, 1995)

Effects of calcium antagonists on the dopamine system - Mena MA, Garcia de Yébenes MJ, Tabernero C, Casarejos MJ, Pardo B, Garcia de Yébenes J (Clinical Neuropharmacology, 1995)

L-DOPA inhibits complex IV of the electron transport chain in catecholamine-rich human neuroblastoma NB69 cells - PARDO, B; MENA, MA; DEYEBENES, JG; (Journal Of Neurochemistry, 1995)

The influence of cell-cell interactions on the differentiation of brain cells in vitro - Pardo Merino, Beatriz (Investigador/a) (1994)

Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line - Pardo B, Mena MA, Fahn S, García de Yébenes J (Movement Disorders, 1993)

Levodopa toxicity in foetal rat midbrain neurones in culture: Modulation by ascorbic acid - MENA, MA; PARDO, B; PAINO, CL; DEYEBENES, JG; (Neuroreport, 1993)

TOXIC EFFECTS OF CAPSAICIN ON CATECHOLAMINE NEURONS - MENA, MA; CASAREJOS, MJ; PARDO, B; DEYEBENES, JG; (Journal Of Neurochemistry, 1993)

Toxicidad de la L-Dopa en cultivos neuronales mecanismo y prevención - Pardo Merino, Beatriz (Autor o Coautor); Beatriz Pardo Merino (Director) Doctorando: Beatriz Pardo Merino (1993)

Neurotoxicity of levodopa on catecholamine-rich neurons - Mena MA, Pardo B, Casarejos MJ, Fahn S, García de Yébenes J (Movement Disorders, 1992)

PROTECTIVE EFFECTS OF ASCORBIC-ACID ON L-DOPA NEUROTOXICITY IN RAT VENTRAL MESENCEPHALIC CULTURES - PARDO, B; PAINO, CL; MENA, MA; (European Journal Of Neuroscience, 1992)

Acute effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in a model of rat designated a poor metabolizer of debrisoquine - Pardo Merino, Beatriz; Jimenezjimenez, FJ; Jimenez-Jimenez, F J; Tabernero, C; Mena, MA; Mena, M A; Deyebenes, JG; Garcia de Yebenes, J; Deyebenes, Mjg; Garcia de Yebenes, M J; Casarejos, MJ; Casarejos, M J; et al. (Journal Of Neurochemistry, 1991)

Marcadores moleculares de la enfermedad de Parkinson - Pardo Merino, Beatriz (Investigador/a) (1991)

Effect of the calcium channel blockers on rotation induced by apomorphine and amphetamine in rats lesioned with 6-hydroxydopamine - Tabernero C; Pardo B; García de Yébenes J (Archivos De Neurobiologia, 1991)

Estudio farmacológico y bioquímico de los efectos de los antagonistas del calcio sobre las neuronas dopaminérgicas - Pardo Merino, Beatriz (Investigador/a) (1989)

Intracerebroventricular infusion of dopamine and its agonists in rodents and primates. An experimental approach to the treatment of Parkinson's disease - Garcia de Yebenes J; Fahn S; Mena MA; Pardo B; Casarejos MJ (Asaio Transactions, 1988)

Estudio farmacológico de líneas celulares obtenidas de neuroblastomas humanos y su utilización como donantes en modelos experimentales de la enfermedad de Parkinson - Pardo Merino, Beatriz (Investigador/a) (1988)

Intracerebroventricular administration of dopamine drugs to experimental models of Parkinsonism? and ? Neuronal transplants with genetically engineired cells in animal models of Parkinson´s disease - Pardo Merino, Beatriz (Investigador/a) (1988)

Functional genomics of pancreatic beta cells and of tissues involved in control of the endocrine pancreas for prevention and treatment of type 2 diabetes - Carrascosa Baeza, Jose Maria (Investigador principal (IP)); Satrustegui Gil Delgado, Jorgina (Investigador principal (IP)) (2006)