A Case-Control of Patients with COVID-19 to Explore the Association of Previous Hospitalisation Use of Medication on the Mortality of COVID-19 Disease: A Propensity Score Matching Analysis - Monserrat Villatoro J; Mejía-Abril G; Díaz García L; Zubiaur P; Jiménez González M; Fernandez Jimenez G; Cancio I; Arribas JR; Suarez Fernández C; Mingorance J; Rodríguez JG; Ferrer JRV; et al. (Pharmaceuticals, 2022)

Acenocoumarol Pharmacogenetic Dosing Algorithm versus Usual Care in Patients with Venous Thromboembolism: A Randomised Clinical Trial - Tong, HY; Borobia, AM; Quintana-Díaz, M; Fabra, S; González-Viñolis, M; Fernández-Capitán, C; Rodriguez-Dávila, MA; Lorenzo, A; López-Parra, AM; Ruiz-Giménez, N; Abad-Santos, F; Suarez, C; et al. (Journal Of Clinical Medicine, 2021)

Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study - Gutiérrez-Gutiérrez, B.; del Toro, M.D.; Borobia, A.M.; Carcas, A.; Jarrín, I.; Yllescas, M.; Ryan, P.; Pachón, J.; Carratalà, J.; Berenguer, J.; Arribas, J.R.; Rodríguez-Baño, J.; et al. (Lancet Infectious Diseases, 2021)

Influence of Genetic Polymorphisms on the Response to Tramadol, Ibuprofen, and the Combination in Patients With Moderate to Severe Pain After Dental Surgery - Saiz-Rodríguez, M.; Valdez-Acosta, S.; Borobia, A.M.; Burgueño, M.; Gálvez-Múgica, M.Á.; Acero, J.; Cabaleiro, T.; Muñoz-Guerra, M.F.; Puerro, M.; Llanos, L.; Martínez-Pérez, D.; Ochoa, D.; et al. (Clinical Therapeutics, 2021)

Health Care Workers' Reasons for Choosing Between Two Different COVID-19 Prophylaxis Trials in an Acute Pandemic Context: Single-Center Questionnaire Study - Borobia, Alberto M.; Garcia-Garcia, Irene; Diaz-Garcia, Lucia; Rodriguez-Mariblanca, Amelia; Martinez de Soto, Lucia; Monserrat Villatoro, Jaime; Seco Meseguer, Enrique; Gonzalez, Juan J.; Frias Iniesta, Jesus; Ramirez Garcia, Elena; Ramon Arribas, Jose; Carcas-Sansuan, Antonio J.; (Journal Of Medical Internet Research, 2021)

Randomised multicentre clinical trial to evaluate voriconazole pre-emptive genotyping strategy in patients with risk of aspergillosis: vorigenipharm study protocol - Monserrat Villatoro, Jaime; Garcia Garcia, Irene; Bueno, David; de la Camara, Rafael; Estebanez, Miriam; Lopez de la Guia, Ana; Abad-Santos, Francisco; Anton, Cristina; Mejia, Gina; Jose Otero, Maria; Ramirez Garcia, Elena; Frias Iniesta, Jesus; et al. (Bmj Open, 2020)

Evaluation of genetic polymorphisms associated with the metabolic effects of aripiprazole and olanzapine - Gandia Juan, Luis (Autor o Coautor); Carcas Sansuan, Antonio Javier (Autor o Coautor); Abad Santos, Francisco (Director) Doctorando: Koller, Dorá (2020)

Research for clinical pharmacogenetics implementation: From candidate gene studies to physiologically based pharmacokinetic modelling - Abad Santos, Francisco (Director); Carcas Sansuan, Antonio Javier (Autor o Coautor); Gandia Juan, Luis (Autor o Coautor) (2020)

Prediction models for voriconazole pharmacokinetics based on pharmacogenetics: AN exploratory study in a Spanish population - Dapía I; García I; Martinez J; Arias P; Guerra P; Díaz L; García A; Ochoa D; Tenorio J; Ramírez E; Román M; Gordo G; et al. (International Journal Of Antimicrobial Agents, 2019)

Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects - Koller D, Belmonte C, Lubomirov R, Saiz-Rodríguez M, Zubiaur P, Román M, Ochoa D, Carcas A, Wojnicz A, Abad-Santos F (Journal Of Psychopharmacology, 2018)

INFLUENCE OF GENETIC POLYMORPHISMS ON THE RESPONSE TO TRAMADOL AND IBUPROFEN IN PATIENTS WITH MODERATE-TO-SEVERE PAIN - Saiz-Rodriguez, M.; Galicia, I; Borobia, A.; Dapia, I; Burgueno, M.; Mugica, M. A. G.; Sanz, J. A.; Cabaleiro, T.; Munoz-Guerra, M. F.; Puerro, M.; Llanos, L.; Gomez-Sanchez, C., I; et al. (Basic & Clinical Pharmacology & Toxicology, 2018)

IPHARMGX PROJECT: NATIONAL COLLABORATIVE STUDY TO EVALUATE EFFECTIVENESS AND EFFICIENCY OF PHARMACOGENETICS IMPLEMENTATION IN THE CLINICAL PRACTICE - Borobia, A. M.; Abad-Santos, F.; Alino, S. F.; Garica Berrocal, B.; Imaz, I.; Llanos, L.; Llerena, A.; Martinez, J. C.; Martinez, A.; Molero, P.; Peiro, A. M.; Sanjurjo, M.; et al. (Basic & Clinical Pharmacology & Toxicology, 2016)

Hepatotoxicity induced by acute and chronic paracetamol overdose in adults. Where do we stand? - Tong H; Medrano N; Borobia A; Martínez A; Martín J; Ruiz J; García S; Quintana M; Carcas A; Frías J; Ramírez E (Regulatory Toxicology And Pharmacology, 2015)

Pharmacogenetics of quetiapine in healthy volunteers: association with pharmacokinetics, pharmacodynamics, and adverse effects - Cabaleiro, Teresa; Lopez-Rodriguez, Rosario; Roman, Manuel; Ochoa, Dolores; Novalbos, Jesus; Borobia, Alberto; Carcas, Antonio; Abad-Santos, Francisco; (International Clinical Psychopharmacology, 2015)

Historia clínica electrónica en los ensayos clínicos de efectividad con medicamentos integrados en la práctica clínica - Carcas Sansuan, Antonio Javier; Abad Santos, Francisco; Sánchez Perruca, Luis; Dal-Ré Saavedra, Rafael (Medicina Clinica, 2015)

Use of pharmacogenetics in bioequivalence studies to reduce sample size: an example with mirtazapine and CYP2D6 - Gonzalez-Vacarezza, N.; Abad-Santos, F.; Carcas-Sansuan, A.; Dorado, P.; Penas-LLedo, E.; Estevez-Carrizo, F.; LLerena, A.; (Pharmacogenomics Journal, 2013)

Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers - López-Rodríguez R; Cabaleiro T; Ochoa D; Román M; Borobia A; Carcas A; Ayuso C; Novalbos J; Abad-Santos F (Pharmacogenomics, 2013)

Influcencia de variables demográficas, clínicas y farmacogenéticas en la dosis estable de acenocumarol y desarrollo de un algoritmo de dosificación - Peiro Vallejo, M Concepcion (Autor o Coautor); Alberto Borobia Perez (Director); Carcas Sansuan, Antonio Javier (Autor o Coautor); Arnalich Fernandez, Francisco (Autor o Coautor) Doctorando: Alberto Borobia Pérez (2013)

Efficiency and effectiveness of the use of an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial - Carcas, AJ; Borobia, AM; Velasco, M; Abad-Santos, F; Díaz, MQ; Fernández-Capitán, C; Ruiz-Giménez, N; Madridano, O; Sillero, PL (Trials, 2012)

Influence of sex and CYP2D6 genotype on mirtazapine disposition, evaluated in Spanish healthy volunteers - Borobia, Alberto M.; Novalbos, Jesus; Guerra-Lopez, Pedro; Lopez-Rodriguez, Rosario; Tabares, Beatriz; Rodriguez, Vanesa; Abad-Santos, Francisco; Carcas, Antonio J.; (Pharmacological Research, 2009)

Digoxin level and clinical manifestations as determinants in the diagnosis of digoxin toxicity - Abad-Santos, F; Carcas, AJ; Ibanez, C; Frias, J; (Therapeutic Drug Monitoring, 2000)

Nimodipine transfer into human breast milk and cerebrospinal fluid - Carcas, AJ; AbadSantos, F; deRosendo, JM; Frias, J; (Annals Of Pharmacotherapy, 1996)

No sex differences in the pharmacokinetics of ranitidine in humans - Carcas Sansuan, Antonio Javier; Abad Santos, Francisco; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (1995)

ACTIVATED-CHARCOAL INCREASES DIGOXIN ELIMINATION IN PATIENTS - IBANEZ, C; CARCAS, AJ; FRIAS, J; ABAD, F; (International Journal Of Cardiology, 1995)

CLINICAL-TRIALS WITH DRUGS - THE INFLUENCE OF THE AUTHORIZATION PROCESS - Carcas AJ, Serrano MA, Avendaño C, Galende I, Tristán C, García-Alonso F (Medicina Clinica, 1995)

RETROPERITONEAL HEMATOMA IN A PATIENT TREATED WITH ACENOCOUMAROL, PHENYTOIN AND PAROXETINE - ABADSANTOS, F; CARCAS, AJ; CAPITAN, CF; FRIAS, J; (Clinical And Laboratory Haematology, 1995)

Estudio de los factores que ayudan al diagnóstico de intoxicación digitálica - Carcas Sansuan, Antonio Javier; Abad Santos, Francisco; Frias Iniesta, Jesus A (1994)

Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial - Montejano, R.; de la Calle-Prieto, F.; Velasco, M.; Guijarro, C.; Queiruga-Parada, J.; Jiménez-González, M.; González-Ruano, P.; Martínez, P.; Goikoetxea, A.J.; Ibarrola, M.; Ciudad, M.; Gutiérrez, Á.; et al. (Clinical Infectious Diseases, 2022)

Enhancing Public Health Communication Regarding Vaccine Trials: Design and Development of the Pan-European VACCELERATE Toolkit - Argyropoulos CD; Leckler J; Salmanton-García J; Constantinou M; Alexandrou A; Themistocleous S; Noula E; Shiamakkides G; Nearchou A; Stewart FA; Albus K; Koniordou M; et al. (Jmir Public Health Surveill, 2023)

No changes in hemostasis after COVID-19?heterologous vaccination schedule: A subanalysis of the phase 2 CombiVacS study - Butta, NV; Arias-Salgado, EG; Manzano, EM; Acuña, P; Román, MTA; Buño-Soto, A; Ramos, JCR; Belda-Iniesta, C; Frías, J; Carcas, AJ; de Soto, LM; Buckley, RD; et al. (Res Pract Thromb Haemost, 2023)

Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR - Schwarz, Megan; Torre, Denis; Lozano-Ojalvo, Daniel; Tan, Anthony T.; Tabaglio, Tommaso; Mzoughi, Slim; Sanchez-Tarjuelo, Rodrigo; Le Bert, Nina; Lim, Joey Ming Er; Hatem, Sandra; Tuballes, Kevin; Camara, Carmen; et al. (Nature Biotechnology, 2022)

A multinational, phase 2, randomised, adaptive protocol to evaluate immunogenicity and reactogenicity of different COVID-19 vaccines in adults ?75 already vaccinated against SARS-CoV-2 (EU-COVAT-1-AGED): a trial conducted within the VACCELERATE network - Neuhann JM, Stemler J, Carcas A, Frías-Iniesta J, Bethe U, Heringer S, Tischmann L, Zarrouk M, Cüppers A, König F, Posch M, Cornely OA (Trials, 2022)

Anti-cancer drug combinations approved by US FDA from 2011 to 2021: main design features of clinical trials and role of pharmacokinetics - Fudio, Salvador; Sellers, Alvaro; Ramos, Laura Perez; Gil-Alberdi, Beatriz; Zeaiter, Ali; Urroz, Mikel; Carcas, Antonio; Lubomirov, Rubin; (Cancer Chemotherapy And Pharmacology, 2022)

Immunogenic dynamics and SARS-CoV-2 variant neutralisation of the heterologous ChAdOx1-S/BNT162b2 vaccination: Secondary analysis of the randomised CombiVacS study - García-Pérez J, González-Pérez M, Castillo de la Osa M, Borobia AM, Castaño L, Bertrán MJ, Campins M, Portolés A, Lora D, Bermejo M, Conde P, Hernández-Gutierrez L, Carcas A, Arana-Arri E, Tortajada M, Fuentes I, Ascaso A, García-Morales MT, Erick de la Torre-Tarazona H, Arribas JR, Imaz-Ayo N, Mellado-Pau E, Agustí A, Pérez-Ingidua C, Gómez de la Cámara A, Ochando J, Belda-Iniesta C, Frías J, Alcamí J, Pérez-Olmeda M, CombiVacS study Group (Eclinicalmedicine, 2022)

Acute Poisoning Readmissions to an Emergency Department of a Tertiary Hospital: Evaluation through an Active Toxicovigilance Program - Munoz Romo, Raul; Borobia Perez, Alberto M.; Mayayo Alvira, Rosa; Urroz, Mikel; Rodriguez Mariblanca, Amelia; Guijarro Eguinoa, Francisco J.; Diaz Garcia, Lucia; Cobo Mora, Julio; Rivera, Angelica; Torres, Rosario; Carcas Sansuan, Antonio J.; (Journal Of Clinical Medicine, 2022)

VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment - Salmanton-Garcia, Jon; Stewart, Fiona A.; Heringer, Sarah; Koniordou, Markela; Alvarez-Barco, Elena; Argyropoulos, Christos D.; Themistocleous, Sophia C.; Valle-Simon, Paula; Spivak, Orly; Souckova, Lenka; Merakou, Christina; Mendonca, Maria Amelia; et al. (Vaccine, 2022)

Implementación en la práctica clínica de la individualización terapéutica de voriconazol mediante una estrategia combinada de biomarcadores farmacogenéticos y farmacocinéticos - Antonio Javier Carcas Sansuan (Director) Doctorando: Irene García García (2022)

Melatonin in the Prophylaxis of SARS-CoV-2 Infection in Healthcare Workers (MeCOVID): A Randomised Clinical Trial - García-García I; Seco-Meseguer E; Ruiz-Seco P; Navarro-Jimenez G; Martínez-Porqueras R; Espinosa-Díaz M; Ortega-Albás JJ; Sagastagoitia I; García-Morales MT; Jiménez-González M; Soto LMd; Bajo-Martínez AI; et al. (Journal Of Clinical Medicine, 2022)

Individualización del tratamiento con acenocumarol: Desarrollo de nuevos algoritmos farmacogenéticos y su validación en enfermedad tromboembólica venosa - Antonio Javier Carcas Sansuan (Director); Alberto Borobia Perez (Director) Doctorando: Hoi Yan Tong (2022)

A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia and/or lymphopenia: RELEASE study protocol - García-García I; Guerra-García P; Ferreras C; Borobia AM; Carcas AJ; Queiruga-Parada J; Vicario JL; Mirones I; Solano C; Eguizabal C; Soria B; Pérez-Martínez A (Trials, 2021)

Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation - Garcia-Garcia, Irene; Dapia, Irene; Montserrat, Jaime; de Soto, Lucia Martinez; Bueno, David; Diaz, Lucia; Queiruga, Javier; Mariblanca, Amelia Rodriguez; Guerra-Garcia, Pilar; Ramirez, Elena; Frias, Jesus; Perez Martinez, Antonio; et al. (Frontiers In Pharmacology, 2021)

Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score - Berenguer J, Borobia AM, Ryan P, Rodríguez-Baño J, Bellón JM, Jarrín I, Carratalà J, Pachón J, Carcas AJ, Yllescas M, Arribas JR, COVID-19@Spain; COVID@HULP Study Groups (Thorax, 2021)

Phase I dose-escalation single centre clinical trial to evaluate the safety of infusion of memory T cells as adoptive therapy in COVID-19 (RELEASE) - Perez-Martinez, A.; Mora-Rillo, M.; Ferreras, C.; Guerra-Garcia, P.; Pascual-Miguel, B.; Mestre-Duran, C.; Borobia, A. M.; Carcas, A. J.; Queiruga-Parada, J.; Garcia, I.; Sanchez-Zapardiel, E.; Gasior, M.; et al. (Eclinicalmedicine, 2021)

Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial (vol 398, pg 121, 2021) - Borobia, A. M.; Carcas, A. J.; Perez-Olmeda, M.; (Lancet, 2021)

EurOP2E - the European Open Platform for Prescribing Education, a consensus study among clinical pharmacology and therapeutics teachers - Bakkum, M.J.; Richir, M.C.; Papaioannidou, P.; Likic, R.; Sanz, E.J.; Christiaens, T.; Costa, J.N.; Ma?iulaitis, R.; Dima, L.; Coleman, J.; Tichelaar, J.; van Agtmael, M.A.; et al. (European Journal Of Clinical Pharmacology, 2021)

A Phase I Dose-Escalation Single Center Study To Evaluate The Safety Of Allogenic Memory T Cells Containing SARS-COV-2 Specific Lymphocytes As Adoptive Therapy in COVID19 - Perez-Martinez, Antonio; Ferreras, Cristina; Mora-Rillo, Marta; Guerra, Pilar; Pascual-Miguel, Barbara; Mesrtre-Duran, Carmen; Borobia, Alberto; Carcas, Antonio; Garcia, Irene; Zapardiel, Elena; Gasior, Mercedes; de Paz, Raquel; et al. (Bone Marrow Transplantation, 2021)

Harmonizing and improving European education in prescribing: An overview of digital educational resources used in clinical pharmacology and therapeutics - Bakkum, M.J.; Tichelaar, J.; Papaioannidou, P.; Likic, R.; Sanz Alvarez, E.J.; Christiaens, T.; Costa, J.N.; Ma?iulaitis, R.; Dima, L.; Coleman, J.; Richir, M.C.; van Agtmael, M.A.; et al. (British Journal Of Clinical Pharmacology, 2021)

A PHASE I/II DOSE-ESCALATION SINGLE CENTER STUDY TO EVALUATE THE SAFETY OF INFUSION OF MEMORY T CELLS AS ADOPTIVE THERAPY IN CORONAVIRUS PNEUMONIA AND /OR LYMPHOPENIA (RELEASE) - Perez-Martinez, A.; Ferreras, C.; Mora-Rillo, M.; Guerra, P.; Pascual-Miguel, B.; Mestre-Duran, C.; Borobia, A. M.; Carcas, A.; Quiroga, J.; Garcia, I.; Sanchez-Zapardiel, E.; Gasior, M.; et al. (Cytotherapy, 2021)

Effectiveness of immunosuppression minimisation, conversion or withdrawal strategies in paediatric solid organ and haematopoietic stem cell transplantation: a protocol of a systematic review and meta-analysis - Martin Saborido C; Borobia AM; Cobas J; D'Antiga L; Frauca E; Hernández-Oliveros F; Jara P; López-Granados E; Muñoz JM; Nicastro E; Ojeda JJ; Pérez-Martínez A; et al. (Bmj Open, 2020)

Incidence of Suspected Serious Adverse Drug Reactions in Corona Virus Disease-19 Patients Detected by a Pharmacovigilance Program by Laboratory Signals in a Tertiary Hospital in Spain: Cautionary Data - Ramírez E; Urroz M; Rodríguez A; González-Muñoz M; Martín-Vega A; Villán Y; Seco E; Monserrat J; Frías J; Carcas AJ; Borobia AM (Frontiers In Pharmacology, 2020)

Predictive engines based on pharmacokinetics modelling for tacrolimus personalized dosage in paediatric renal transplant patients - Prado-Velasco M; Borobia A; Carcas-Sansuan A (Scientific Reports, 2020)

Strategy to effectively and efficiently implement voriconazole pharmacogenetics in clinical practice - García IG; Carcas AJ; Borobia AM (Pharmacogenomics, 2020)

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial - García IG; Rodriguez-Rubio M; Mariblanca AR; de Soto LM; García LD; Villatoro JM; Parada JQ; Meseguer ES; Rosales MJ; González J; Arribas JR; Carcas AJ; et al. (Trials, 2020)

The need to implement nonindustry COVID-19 clinical trials in non-high-income countries - Dal-Ré R; Carcas AJ; Sreeharan N (Journal Of Global Health, 2020)

Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients With Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments - Borobia AM, Collado SG, Cardona CC, Pueyo RC, Alonso CF, Torres IP, González MC, Casal Codesido JR, Betegón MA, Barcela LA, Andicoechea AO, Testa AF, Colina JT, Dorribo AC, Del Arco Galán C, Martínez Ávila JC, Lugilde ST, Carcas Sansuán AJ, InMEDIATE Investigators Group (Annals Of Emergency Medicine, 2020)

Cross-cutting view of current challenges in paediatric solid organ and haematopoietic stem cell transplantation in Europe: The European Reference Network TransplantChild - Jara P, Baker A, Baumann U, Borobia AM, Branchereu S, Candusso M, Carcas AJ, Chardot C, Cobas J, D'Antiga L, Ferreras C, Fitzpatrick E, Frauca E, Hernández-Oliveros F, Kalici?ski P, Lindemans C, Lopes MF, López-Granados E, de Magnée C, Mota C, Muñoz JM, Ojeda JJ, Pérez-Martínez A, Perilongo G, Rascon J, Sciveres M, Stone R, Tarutis V, Toporski J, Torres JM, Wennberg L, ERN TransplantChild (Orphanet Journal Of Rare Diseases, 2020)

A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe - Borobia, Alberto M.; Carcas, Antonio J.; Arnalich, Francisco; Alvarez-Sala, Rodolfo; Monserrat-Villatoro, Jaime; Quintana, Manuel; Carlos Figueira, Juan; Torres Santos-Olmo, Rosario M.; Garcia-Rodriguez, Julio; Martin-Vega, Alberto; Buno, Antonio; Ramirez, Elena; et al. (Journal Of Clinical Medicine, 2020)

Evaluating the optimal time for amikacin administration with respect to haemodialysis using an in vitro pharmacodynamic simulation against epidemic nosocomial OXA-48 producing Klebsiella pneumoniae ST405 strains - Carcas A; Sevillano D; González N; Alou L; Gómez-Gil R; Muñoz M; Llanos L; Sanchez-Villanueva R; Gonzalez-Parra E; Giménez M; Aguilar L (Journal Of Global Antimicrobial Resistance, 2019)

Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals - Danese, Elisa; Raimondi, Sara; Montagnana, Martina; Tagetti, Angela; Langaee, Taimour; Borgiani, Paola; Ciccacci, Cinzia; Carcas, Antonio J.; Borobia, Alberto M.; Tong, Hoi Y.; Davila-Fajardo, Cristina; Botton, Mariana Rodrigues; et al. (Clinical Pharmacology & Therapeutics, 2019)

Farmacocinética comparada de Prograf y Advagraf y desarrollo de modelos clínico-genéticos para la predicción de la disposición de tacrolimus en niños trasplantados. - Antonio Javier Carcas Sansuan (Director) Doctorando: Gonçalo N. Paulo Almeida (2018)

Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction (vol 14, 70, 2018) - Martínez-Ávila J; García Bartolomé A; García I; Dapía I; Tong H; Díaz L; Guerra P; Frías J; Carcás Sansuan A; Borobia A (Metabolomics, 2018)

Pharmacometabolomics applied to zonisamide pharmacokinetic parameter prediction - Martínez-Ávila J; García Bartolomé A; García I; Dapía I; Tong H; Díaz L; Guerra P; Frías J; Carcás Sansuan A; Borobia A (Metabolomics, 2018)

Clinical Implementation of Pharmacogenetic Testing in a Hospital of the Spanish National Health System: Strategy and Experience Over 3 Years - Borobia A; Dapia I; Tong H; Arias P; Muñoz M; Tenorio J; Hernández R; García García I; Gordo G; Ramírez E; Frías J; Lapunzina P; et al. (Cts-Clinical And Translational Science, 2018)

Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant - Almeida-Paulo, G. N.; Dapia Garcia, I.; Lubomirov, R.; Borobia, A. M.; Alonso-Sanchez, N. L.; Espinosa, L.; Carcas-Sansuan, A. J.; (Pharmacogenomics Journal, 2018)

Eficiencia en el diagnóstico y tratamiento de la intoxicación aguda por paracetamol: análisis de costeefectividad a través de un programa de toxicovigilancia activa hospitalario - Muñoz Romo, Raúl; Borobia Pérez, Alberto; Muñoz, Mario A; Carballo Cardona, César; Cobo Mora, Julio; Carcas Sansuan, Antonio Javier (Emergencias: Revista De La Sociedad Española De Medicina De Urgencias Y Emergencias, 2018)

Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study - Brinkman, David J.; Tichelaar, Jelle; Mokkink, Lidwine B.; Christiaens, Thierry; Likic, Robert; Maciulaitis, Romaldas; Costa, Joao; Sanz, Emilio J.; Maxwell, Simon R.; Richir, Milan C.; van Agtmael, Michiel A.;Educ Working Grp European Assoc Cl; Network Teachers Pharmacotherapy (Clinical Pharmacology & Therapeutics, 2018)

Efficient diagnosis and treatment of acute paracetamol poisoning: cost-effectiveness analysis of approaches based on a hospital toxicovigilance program - Munoz Romo, Raul; Borobia Perez, Alberto M.; Munoz, Mario A.; Carballo Cardona, Cesar; Cobo Mora, Julio; Carcas Sansuan, Antonio J.; (Emergencias: Revista De La Sociedad Española De Medicina De Urgencias Y Emergencias, 2018)

Monitorización terapeútica de los fármacos - Carcas Sansuan, Antonio Javier; Borobia Pérez, Alberto; Lubomirov Hirtov, R; Frías Iniesta, José (Velázquez: Farmacología Básica Y Clínica, 2018)

Transplantchild, an European strategy to attend "the secondary rare disease" induced by paediatric transplantation - Frauca, Esteban; Hernandez, Francisco; Perez-Martinez, Antonio; Lopez-Granados, Eduardo; Carcas, Antonio; Jonay Ojeda, Jose; Jara, Paloma; Torres, Juan; Tejedor, Marisa; Coloma, Ana; Cobas, Javier; (Transplantation, 2018)

Who is willing to participate in low-risk pragmatic clinical trials without consent? - Dal-Ré R, Carcas AJ, Carné X (European Journal Of Clinical Pharmacology, 2017)

Patients' beliefs regarding informed consent for low-risk pragmatic trials. - Dal-Ré R, Carcas AJ, Carné X, Wendler D (Bmc Medical Research Methodology, 2017)

Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population - Tong H; Borobia A; Martínez Ávila J; Lubomirov R; Muñoz M; Bañares M; Hernández R; Fernández Capitán C; Ramírez E; Frías J; Carcas A (Pharmacogenomics, 2017)

Appropriate use of red blood cell transfusion in emergency departments: A study in five emergency departments - Díaz, MQ; Borobia, AM; Erce, JAG; Maroun-Eid, C; Fabra, S; Carcas, A; Frías, J; Muñoz, M (Blood Transfusion, 2017)

Comparative effectiveness medicines research cannot assess efficacy - Dal-Re, Rafael; Carcas, Antonio J.; (Journal Of Clinical Epidemiology, 2017)

Ciencia Iberoamericana para el Mundo - Borobia, Alberto M.; NA, NA; Carcas, Antonio J.; NA, NA (Ibj Clinical Pharmacology, 2017)

Implementación de la farmacogenética en la práctica clínica: hacia las estrategias de genotipado anticipado - Borobia, Alberto M.; NA, NA; Carcas, Antonio J.; NA, NA (Ibj Clinical Pharmacology, 2017)

Effect of the CYP3A5, CYP3A4, CYP3A7, ABCB1, POR and NR1I2 genes in the pharmacokinetics of tacrolimus in a pediatric cohort with stable serum concentrations after renal transplantation: study protocol. - Dapia, Irene; NA, NA; Tabakov, Aleksandra; Espinosa Román, Laura; Díaz, Lucía; Arias Lajara, Pedro; Melgosa, Marta; Melgar, Angel; Fernández, Carlota; Herranz Estellés, Alicia; Lapunzina, Pablo; Borobia, Alberto M.; et al. (Ibj Clinical Pharmacology, 2017)

Acute Pancreatitis by liposomal amphotericin B. - Hernández, Rafael; NA, NA; Rico, Alicia; Rios, Peggy; Ramírez, Elena; Carcas, Antonio J.; NA, NA; NA, NA (Ibj Clinical Pharmacology, 2017)

Significant HLA class I type associations with aromatic antiepileptic drug (AED)-induced SJS/TEN are different from those found for the same AED-induced DRESS in the Spanish population. - Ramírez, E.; Bellón, T.; Tong, H.Y.; Borobia, A.M.; de Abajo, F.J.; Lerma, V.; Moreno Hidalgo, M.A.; Castañer, J.L.; Cabañas, R.; Fiandor, A.; González-Ramos, J.; Herranz, P.; et al. (Pharmacological Research, 2017)

Eosinophilic drug reactions detected by a prospective pharmacovigilance programme in a tertiary hospital - Ramírez E; Medrano-Casique N; Tong H; Bellón T; Cabañas R; Fiandor A; González-Ramos J; Herranz P; Trigo E; Muñoz M; Borobia A; Carcas A; et al. (British Journal Of Clinical Pharmacology, 2017)

Public preferences on written informed consent for low-risk pragmatic clinical trials in Spain - Dal-Ré R; Carcas AJ; Carné X; Wendler D (British Journal Of Clinical Pharmacology, 2017)

Nonchemotherapy drug-induced agranulocytosis in children detected by a prospective pharmacovigilance program - Medrano-Casique N; Tong H; Borobia A; Carcas A; Frias J; Ramírez E (Pediatric Hematology And Oncology, 2016)

Limited sampling strategies for once daily tacrolimus exposure monitoring - Carcas-Sansuán AJ (European Journal Of Clinical Pharmacology, 2016)

Invasive aspergillosis in a paediatric allogeneic stem cell transplantation recipient owing to a susceptible Aspergillus fumigatus: Treatment failure with high doses of voriconazole and influence of CYP2C19 polymorphisms - Cendejas-Bueno E; Borobia A; Gomez-Lopez A; Escosa-García L; Río-García M; Plaza D; García-Rodriguez J; Carcas-Sansuán A (International Journal Of Antimicrobial Agents, 2016)

Outcomes and Costs of Poisoned Patients Admitted to an Adult Emergency Department of a Spanish Tertiary Hospital: Evaluation through a Toxicovigilance Program - Muñoz R, Borobia AM, Quintana M, Martínez A, Ramírez E, Muñoz M, Frías J, Carcas AJ (Plos One, 2016)

A new pharmacogenetic algorithm to predict the most appropriate dosage of acenocoumarol for stable anticoagulation in a mixed Spanish population - Tong HY, Dávila-Fajardo CL, Borobia AM, Martínez-González LJ, Lubomirov R, Perea León LM, Blanco Bañares MJ, Díaz-Villamarín X, Fernández-Capitán C, Cabeza Barrera J, Carcas AJ, PGX-ACE Investigators Group (Plos One, 2016)

Design of a pharmacogenetic algorithm to predict the therapeutic dose of acenocoumarol - Tong, H.; Davila Fajardo, C. L.; Borobia, A.; Martinez Gonzalez, L. J.; Pera Leon, L.; Diaz Villamarin, X.; Carcas Sansuan, A.; (International Journal Of Clinical Pharmacy, 2016)

A RANDOMIZED CLINICAL TRIAL OF GENOTYPE-GUIDED DOSING OF ACENOCOUMAROL IN SPANISH PATIENTS WITH VENOUS THROMBOEMBOLIC DISEASE (VTED) - Tong, H. Y.; Borobia, A. M.; Rodriguez, M. A.; Ruiz-Gimenez, N.; Lorenzo, A.; Gonzalez Vinolis, M.; Madridano, O.; Fabra, S.; Lopez Parra, A. M.; Arroyo, E.; Baeza, C.; Llamas, P.; et al. (Basic & Clinical Pharmacology & Toxicology, 2016)

HIGH DOSE-METOTREXATE (HD-MTX) TOXICITY IN A PEDIATRIC COHORT WITH LAL: CHARACTERISTICS AND CARBOXIPEPTIDASE USE - Garcia, I. G.; Alvarez, E.; Alvarez, Ch; Diaz, L.; Tong, H. Y.; Hernandez, R.; Borobia, A. M.; Ramirez, E.; Frias, J.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2016)

THERAPEUTIC DRUG MONITORING OF VANCOMYCIN (TDM-V) IN NEONATES AND PAEDIATRICS: EVALUATION OF GUIDELINES AND RECOMMENDATIONS - Diaz, L.; Garcia, I; Hernandez, R.; Munoz, M.; Frias, J.; Ramirez, E.; Borobia, A. M.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2016)

USE OF A CUSTOM PHARMACOGENETICS SNP-ARRAY (PHARMARRAY (R)) FOR CYP2C19 GENOTYPING IN PEDIATRIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) PATIENTS FOR ASPERGILLOSIS TREATMENT WITH VORICONAZOLE - Munoz, M.; Dapia, I; Tenorio, J.; Garcia, I. G.; Tong, H. Y.; Arias, P.; Perez, A.; Lapunzina, P.; Carcas, A. J.; Borobia, A. M.; (Basic & Clinical Pharmacology & Toxicology, 2016)

ACUTE POISONING READMISSIONS IN A SPANISH TERTIARY HOSPITAL: STUDY THROUGH A TOXICOVIGILANCE PROGRAM - Munoz, R.; Garcia, I; Diaz, L.; Munoz, M.; Hernandez, R.; Tong, H. Y.; Ramirez, E.; Frias, J.; Borobia, A. M.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2016)

PHARMACOGENETICS IN THE CLINICAL PRACTICE: DESIGN AND IMPLEMENTATION OF A CUSTOMIZED PHARMACOGENETICS GENOTYPING ARRAY (CLINPHARMARRAY (R)) - Munoz, M.; Dapia, I; Tenorio, J.; Arias, P.; Zabala, R. H.; Tong, H. Y.; Frias, J.; Lapunzina, P.; Carcas, A. J.; Borobia, A. M.; (Basic & Clinical Pharmacology & Toxicology, 2016)

INCIDENCE OF PANCREATITIS, DRUG-INDUCED OR OTHER CAUSES, IN A TERTIARY CARE HOSPITAL - Hernandez, R.; Munoz, M.; Queiruga Parada, J.; Rodriguez Mariblanca, A.; Diaz, L.; Borobia, A. M.; Carcas, A. J.; Frias, J.; Ramirez, E.; (Basic & Clinical Pharmacology & Toxicology, 2016)

Involvement of CC Chemokine Receptor 1 and CCL3 in Acute and Chronic Inflammatory Pain in Mice - Llorian-Salvador, Maria; Gonzalez-Rodriguez, Sara; Lastra, Ana; Teresa Fernandez-Garcia, Maria; Hidalgo, Agustin; Menendez, Luis; Baamonde, Ana; (Basic & Clinical Pharmacology & Toxicology, 2016)

Non-Chemotherapy-Induced Agranulocytosis Detected by a Prospective Pharmacovigilance Program in a Tertiary Hospital. - Medrano-Casique N, Tong HY, Borobia AM, Carcas AJ, Frías J, Ramírez E (Basic & Clinical Pharmacology & Toxicology, 2015)

High dose favipiravir: fist experience in a patient with Ebola - Borobia, A. M.; Mora-Rillo, M.; Ramirez Olivencia, G.; Lago, M.; Arsuaga, M.; De la Calle, F.; Arnalich, F.; Arribas, J. R.; Carcas, A. J.; (Clinical Therapeutics, 2015)

Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease contracted in Madrid, Spain - Mora-Rillo, Marta; Arsuaga, Marta; Ramirez-Olivencia, German; de la Calle, Fernando; Borobia, Alberto M.; Sanchez-Seco, Paz; Lago, Mar; Figueira, Juan C.; Fernandez-Puntero, Belen; Viejo, Aurora; Negredo, Anabel; Nunez, Concepcion; et al. (Lancet Respiratory Medicine, 2015)

PHARMACOGENETIC IMPLEMENTATION IN THE ROUTINE CLINICAL PRACTICE: DESIGN OF A MULTICENTER PILOT CLINICAL TRIAL - Borobia, A. M.; Lubomirov, R.; Abad, F.; Tong, H. Y.; Ramirez, E.; Frias, J.; Carcas, A. J.; (Clinical Therapeutics, 2015)

IMPLEMENTING PHARMACOGENETICS: PHARMARRAY (R) AND PHARMACOGENETIC CONSULTATION - Borobia, A. M.; Lubomirov, R.; Tong, H. Y.; Arias, P.; Tenorio, J.; Frias, J.; Lapunzina, P.; Carcas, A. J.; (Clinical Therapeutics, 2015)

SCREENING AND RECRUITMENT PROCEDURES OF HEALTHY VOLUNTEERS IN A PHASE I CLINICAL TRIAL UNIT: EXPERIENCE IN 64 BIOEQUIVALENCE STUDIES - Duque, B.; Borobia, A. M.; Lubomirov, R.; Ramirez, E.; Guerra, P.; Medrano, N.; Tong, H. Y.; Carcas, A. J.; Frias, J.; (Clinical Therapeutics, 2015)

UAM COURSE ON GOOD CLINICAL PRACTICE (GCPS) FOR INVESTIGATORS: A 3 YEARS EXPERIENCE - Duque, B.; Borobia, A. M.; Lubomirov, R.; Ramirez, E.; Guerra, P.; Medrano, N.; Tong, H. Y.; Carcas, A. J.; Frias, J.; (Clinical Therapeutics, 2015)

A PHARMACOVIGILANCE PROGRAM FROM LABORATORY SIGNALS IN HOSPITALIZAED PATIENTS: RESULTS OF 2014 - Ramirez, E.; Tong, H. Y.; Medrano, N.; Munoz, M.; Hernandez, R.; Borobia, A. M.; Carcas, A. J.; Frias, J.; (Clinical Therapeutics, 2015)

CYTOCHROME P450 OXIDOREDUCTASE CONTRIBUTION ON AN ACENOCOUMAROL DOSING ALGORITHM - Tong, H. Y.; Borobia, A. M.; Lubomirov, R.; Hernandez, R.; Munoz, M.; Ramirez, E.; Frias, J.; Carcas, A. J.; (Clinical Therapeutics, 2015)

Conversion from Prograf to Advagraf in stable paediatric renal transplant patients and 1-year follow-up - Espinosa Roman, Laura; Carcas Sansuan, Antonio Javier; Carcas-Sansuan, Antonio J; Almeida-Paulo, Gonzalo N; Alonso-Melgar, Angel; Garcia-Meseguer, Carmen; Fernandez-Camblor, Carlota; Medrano, Nicolas; Ramirez, Elena (Pediatric Nephrology, 2014)

COMPARATIVE EFFECTIVENESS RESEARCH: THE INTEGRATION OF RESEARCH INTO CLINICAL PRACTICE - Carcas Sansuan, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2014)

Limited sampling strategies for tacrolimus exposure (AUC0-24) prediction after Prograf® and Advagraf® administration in children and adolescents with liver or kidney transplants - Almeida-Paulo G; Lubomirov R; Alonso-Sanchez N; Espinosa-Román L; Fernández Camblor C; Díaz C; Muñoz Bartola G; Carcas-Sansuán A (Transplant International, 2014)

Conversion From Prograf to Advagraf in Adolescents With Stable Liver Transplants: Comparative Pharmacokinetics and 1-Year Follow-Up - Carcas-Sansuán AJ, Hierro L, Almeida-Paulo GN, Frauca E, Tong HY, Díaz C, Piñana E, Frías-Iniesta J, Jara P (Liver Transplantation, 2013)

Vancomycin-Induced Acute Kidney Injury Detected by a Prospective Pharmacovigilance Program From Laboratory Signals - Ramírez E, Jiménez C, Borobia AM, Tong HY, Medrano N, Krauel-Bidwell L, Carcas AJ, Selgas R, Frías J (Therapeutic Drug Monitoring, 2013)

A preliminary model to avoid the overestimation of sample size in bioequivalence studies - Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A; Carcas Sansuan, Antonio Javier; Ramirez, E; Abraira, V; Borobia, A M; Duque, B; Lopez, J L; Mosquera, B; Lubomirov, R; Carcas, A J (Drug Research, 2013)

Limited sampling strategies (LSS) for tacrolimus monitoring after Adavagraf (R) and Prograf (R) administration in children with stable renal transplantation - Espinosa, L; Almeida-Paulo, G N; Alonso-Sanchez, N L; Garcia Meseguer, C; Alonso-Melgar, A; Campos-Saudin, A J; Carcas, A J (Pediatric Nephrology, 2013)

A multiplex assay to detect variations in the CYP2C9, VKORC1, CYP4F2 and APOE genes involved in acenocoumarol metabolism - López-Parra AM, Borobia AM, Baeza C, Arroyo-Pardo E, Carcas AJ (Clinical Biochemistry, 2013)

Drug-induced life-threatening potassium disturbances detected by a pharmacovigilance program from laboratory signals - Ramírez E, Rossignoli T, Campos AJ, Muñoz R, Zegarra C, Tong H, Medrano N, Borobia AM, Carcas AJ, Frías J (European Journal Of Clinical Pharmacology, 2013)

Development and validation of a poisoning surveillance program with automatic case detection in a tertiary care hospital (SAT-HULP) - Muñoz R; Borobia A; Quintana M; Martínez-Virto A; Frías J; Carcas Sansuan A (Emergencias: Revista De La Sociedad Española De Medicina De Urgencias Y Emergencias, 2013)

SCIENTIFIC PRODUCTIVITY OF CLINICAL PHARMACOLOGY DEPARTMENTS IN SPANISH HOSPITALS: EVALUATION TROUGH PUBMED - Tong, H. Y.; Munoz, M. A.; Torres, R. A.; Medrano, N.; Borobia, A. M.; Ramirez, E.; Carcas, A. J.; Frias, J.; (Basic & Clinical Pharmacology & Toxicology, 2013)

Conversion of Prograf (R) to Adavagraf (R) in paediatric kidney transplant - Espinosa, Laura; Garcia Meseguer, Carmen; Alonso, Angel; Fernandez Camblor, Carlota; Melgosa, Marta; Navarro, Mercedes; Campos, Armando; Carcas, Antonio (Pediatric Nephrology, 2013)

Desarrollo y validación de un programa de toxicovigilancia con detección automatizada de casos en un hopital terciario (SAT-HULP) - Muñoz Romo, Raúl; Borobia Pérez, Alberto; Quintana Díaz, Manuel; Martínez Virto, Ana María; Frías, Jesús; Carcas, Antonio J (Emergencias: Revista De La Sociedad Española De Medicina De Urgencias Y Emergencias, 2013)

An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease - Borobia A; Lubomirov R; Ramírez E; Lorenzo A; Campos A; Muñoz-Romo R; Fernández-Capitán C; Frías J; Carcas A (Plos One, 2012)

Use of antifungal agents in pediatric and adult high-risk areas - Ramírez E; García-Rodríguez J; Borobia AM; Ortega JM; Lei S; Barrios-Fernández A; Sánchez M; Carcas AJ; Herrero A; De La Puente JM; Frías J (European Journal Of Clinical Microbiology & Infectious Diseases, 2012)

DIFFERENCES BETWEEN PEDIATRIC AND ADULT POPULATIONS HAVING DRUG INDUCED AGRANULOCYTOSIS - Medrano, N.; Tong, H. Y.; Borobia, A. M.; Carcas, A. J.; Frias, J.; Ramirez, E.; (Basic & Clinical Pharmacology & Toxicology, 2012)

CYP4F2 AND APOE CONTRIBUTION IN ACENOCOUMAROL DOSING BASED ON GENOTYPE: A COMPARISON OF TWO ALGORITHMS - Tong, H. Y.; Borobia, A. M.; Lei, S. H.; Ramirez, E.; Frias, J.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2012)

SINGLE INSTITUTION PHASE I TRIAL OF THE NOVEL COMPOUND FIRST-IN-CLASS PDM08 IN REFRACTORY SOLID TUMORS (NCT01380249) - Barriuso, J.; Soria, I.; Moreno, V.; Coronado, M.; Galicia, I.; Figueredo, M. A.; Frias, J.; Feliu, J.; Carcas, A.; Subiza, J. L.; (Annals Of Oncology, 2012)

Phase I trial in advanced refractory solid tumors of the new drug first-in-class PDM08. - Barriuso, Jorge; Moreno, Victor; Coronado, Monica; Galicia, Ignacio; Soria, Irene; de Castro, Javier; Belda-Iniesta, Cristobal; Martinez Marin, Virginia; Custodio, Ana; Redondo, Andres; Lamarca, Angela; Hindi, Nadia; et al. (Journal Of Clinical Oncology, 2012)

A LIMITED SAMPLING STRATEGY (LSS) FOR TACROLIMUS MONITORING AFTER ADVAGRAF (R) ADMINISTRATION IN CHILDREN WITH STABLE RENAL AND LIVER TRANSPLANTATION - Alonso, L; Nuno-Almeida, G; Campos, A; Hierro, L; Espinosa, L; Jara, P; Alonso-Melgar, A; Garcia-Meseguer, M C; Tong, H; Ramirez, E; Carcas-Sansuan, A J (Basic & Clinical Pharmacology & Toxicology, 2011)

RELATIVE BIOAVAILABILITY OF TWO TACROLIMUS FORMULATIONS: PROGRAF (R) (NORMAL RELEASE) AND ADVAGRAF (R) (SUSTAINED RELEASE) IN CHILDREN WITH KIDNEY TRANSPLANT - Campos, A.; Espinosa, L.; Medrano, N.; Alonso-Melgar, A.; Alonso, L.; Nuno-Almeida, G.; Tong, H.; Ramirez, E.; Frias-Iniesta, J.; Carcas-Sansuan, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2011)

ACENOCOUMAROL DOSING ALGORITHM INCLUDING CLINICAL, DEMOGRAPHIC AND PHARMACOGENETIC DATA (CYP2C9, VKORC1, CYP4F2 AND APOE) FOR USE IN PATIENTS WITH THE THROMBOEMBOLIC DISEASE - Borobia, A. M.; Lubomirov, R.; Ramirez, E.; Lorenzo, A.; Campos, A.; Fernandez-Capitan, C.; Frias, J.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2011)

Estudio de utilización de transfusión de hemoderivados en un servicio de urgencias e intervención educativa (EC 10-215) - Carcas Sansuan, Antonio Javier (Investigador principal (IP)); Quintana Diaz, Manuel (Colaborador/a) (2011)

A MODEL-BASED COST-EFFECTIVENESS ANALYSIS OF CLOPIDOGREL PHARMACOGENOMIC TESTING - Lubomirov, R.; Borobia, A. M.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2011)

INCIDENCE AND PREDICTORS OF SEVERE POTASSIUM DISTURBANCES, DETECTED BY A PHARMACOVIGILANCE PROGRAM FROM LABORATORY SIGNALS AT HOSPITAL - Ramirez, E.; Tong, H. Y.; Campos, A.; Munoz, R.; Medrano, N.; Krauel-Bidwell, L.; Egana, A.; Zegarra, C.; Borobia, A.; Carcas, A.; Frias, J.; (Basic & Clinical Pharmacology & Toxicology, 2011)

Overuse of PPIs in Patients at Admission, During Hospitalisation, and at Discharge in a Terciary Spanish Hospital - Ramirez E, Lei SH, Borobia AM, Piñana E, Fudio S, Muñoz R, Campos A, Carcas AJ, Frias J (Current Clinical Pharmacology, 2010)

Valproate-meropenem interaction as an example of information shortcomings in relevant drug interactions Reply - Borobia, Alberto M.; Fudio, Salvador; Carcas Sansuan, Antonio J.; (Medicina Clinica, 2010)

Acceptability and characteristics of 124 human bioequivalence studies with active substances classified according to the Biopharmaceutic Classification System. - Ramirez E, Laosa O, Guerra P, Duque B, Mosquera B, Borobia AM, Lei SH, Carcas AJ, Frias J (British Journal Of Clinical Pharmacology, 2010)

Incidencia de hiperkalemia severa inducida por medicamentos en un hospital terciario - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2010)

DRESS-syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpevirus 6 in an 11-year-old caucasian boy - Piñana E, Lei SH, Merino R, Melgosa M, De La Vega R, Gonzales-Obeso E, Ramírez E, Borobia A, Carcas A (Journal Of Clinical Pharmacy And Therapeutics, 2010)

Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers - Oliver P, Lubomirov R, Carcas A (Clinical Chemistry And Laboratory Medicine, 2010)

Ensayo Clínico randomizado para evaluar la eficiencia y efectividad de la dosificación individualizada de Acenocumarol mediante un algoritmo farmacogenético versus ajuste estándar en pacientes que inician anticoagulación oral. - Suarez Fernandez, M Carmen (Investigador principal (IP)) (2010)

Evaluation of the influence of sex and CYP2C19 and CYP2D6 polymorphisms in the disposition of citalopram - Fudio S, Borobia AM, Piñana E, Ramírez E, Tabarés B, Guerra P, Carcas A, Frías J (European Journal Of Pharmacology, 2010)

Incidence of severe hyponatremia drug-induced and other causes in a terciary care hospital - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2010)

Maximising Benefits And Minimizing Harms From Drugs Influence Of Gender On Clopidogrel Disposition In Healthy Volunteers - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2010)

A Pharmacovigilance Program From Laboratory Signals for the Detection and Reporting of Serious Adverse Drug Reactions in Hospitalized Patients - Ramirez E, Carcas AJ, Borobia AM, Lei SH, Piñana E, Fudio S, Frias J (Clinical Pharmacology & Therapeutics, 2010)

Use of Proton Pump Inhibitors (PPIs) in a Spañish Terciary - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2009)

Trough Tacrolimus Concentrations in the First Week After Kidney Transplantation Are Related to Acute Rejection - Borobia AM, Romero I, Jimenez C, Gil F, Ramirez E, De Gracia R, Escuin F, Gonzalez E, Sansuán AJ (Therapeutic Drug Monitoring, 2009)

Valproate-meropenem co-administration, an example of information shortcomings in relevant drug interactions - Borobia AM, Fudio S, Carcas Sansuán AJ (Medicina Clinica, 2009)

La proporción de la masa muscular y su influencia en la evolución del bloqueo neuromuscular inducido por bromuro de rocuronio - Rodriguez Montes, Jose Antonio (Autor o Coautor); Carcas Sansuan, Antonio Javier (Autor o Coautor); Gilsanz Rodriguez, Fernando (Director) Doctorando: Martínez Torrente, Francisco (2009)

CYP2C9 polymorphism in five autochthonous population of the same geographic area (Spanish Pyrenees) - Borobia AM, López-Parra AM, Tabarés B, Ramirez E, Baeza C, Arroyo-Pardo E, Carcas AJ (Pharmacological Research, 2009)

In Vitro Analysis of Synergism and Antagonism of Different Nucleoside/Nucleotide Analogue Combinations on the Inhibition of Human Immunodeficiency Virus Type 1 Replication - Perez-Olmeda M, Garcia-Perez J, Mateos E, Spijkers S, Ayerbe MC, Carcas A, Alcami J (Journal Of Medical Virology, 2009)

CONVERSION FROM PROGRAF TO ADVAGRAF IN ADOLESCENTS WITH NORMAL GRAFT FUNCTION AFTER LIVER TRANSPLANTATION - Hierro, Loreto; Pinana, Enrique; Frauca, Esteban; de la Vega, Angela; Camarena, Carmen; Munoz Bartolo, Gema; Diaz, Carmen; Dolores Lledin, Maria; Hernandez, Francisco; Leal, Nuria; Gamez, Manuel; Luis Encinas, Jose; et al. (Transplant International, 2009)

CONVERSION FROM PROGRAF TO ADVAGRAF IN ADOLESCENTS WITH NORMAL GRAFT FUNCTION AFTER LIVER TRANSPLANTATION: BIOEQUIVALENCE ON 1:1 DAILY DOSE - Jara, Paloma; Hierro, Loreto; Pinana, Enrique; Camarena, Carmen; de la Vega, Angela; Frauca, Esteban; Munoz Bartolo, Gema; Diaz, Carmen; Hernandez, Francisco; Leal, Nuria; Murcia, Javier; Gamez, Manuel; et al. (Liver Transplantation, 2009)

EVALUATION OF LIMITED SAMPLING STRATEGIES FOR TACROLIMUS EXTENDED-RELEASE FORMULATION IN LIVER TRANSPLANT PATIENTS - Pinana, E.; Campos, A.; Laosa, O.; Munoz, R.; Suhua, Lei A.; Ramirez, E.; Carcas, A.; (Basic & Clinical Pharmacology & Toxicology, 2009)

Riesgo de enfermedad tromboembólica y estudio de utilización de tromboprofilaxis en pacientes médicos hospitalizados y al alta hospitalaria - Borobia Pérez, Alberto; Fernández Capitán, Carmen; Iniesta Arandia, Nerea; García de Paso Mora, Pablo; Valero Recio, José Manuel; Bizighescu, Magdalena; Carcas Sansuan, Antonio Javier (Revista Clinica Espanola, 2009)

Hypercalcemia due to an interaction of all-trans retinoic acid (ATRA) and itraconazole therapy for acute promyelocytic leukemia successfully treated with zoledronic acid - Cordoba R; Ramirez E; Lei SH; Lopez De La Guia A; Sanjurjo MJ; Carcas AJ; Hernandez-Navarro F (European Journal Of Clinical Pharmacology, 2008)

The importance of sample size, log-mean ratios, and intrasubject variability in the acceptance criteria of 108 bioequivalence studies. - Ramirez E, Guerra P, Laosa O, Duque B, Tabares B, Lei SH, Carcas AJ, Frias J (European Journal Of Clinical Pharmacology, 2008)

Sublingual administration of tacrolimus in a renal transplant patient - Romero I, Jiménez C, Gil F, Escuin F, Ramirez E, Fudio S, Borobia A, Carcas A (Journal Of Clinical Pharmacy And Therapeutics, 2008)

Evaluation of the impact of cyp2c19 and cyp2d6 genotype in the pharmacokinetics of citalopram¿ iuphar - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2008)

The important of BCS clases in the acceptance of 109 bioequivalence studies - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (2008)

Validation of denaturing hplc (dhplc) to determine genotypic variants of thiopurine s-methyltransferase (TPMT) in patients with inflammatory bowel disease (IBD) - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2008)

In vitro analysis of synergism/antagonism effect of different nucleoside/nucleotide analogues combinations on the inhibition of HIV-1 replication - Perez-Olmeda, M.; Garcia-Perez, J.; Mateos, E.; Spijkers, S.; Ayerbe, M. C.; Carcas, A.; Alcami, J.; (Antiviral Therapy, 2008)

Psychosis, visual hallucinations and worsening renal function due to a gabapentine-morphine interaction - Borobia-Pérez AM; Fernández-Capitán C; Carcas-Sansuán AJ (Revista De Neurologia, 2008)

Effect of the hematocrit and its correction on the relationship between blood tacrolimus concentrations obtained using the microparticle enzyme immunoassay (MEIA) and enzyme multiplied immunoassay technique (EMIT) - Bouzas L, Ortega FJ, Casado P, Arranz MI, Carcas A, Tutor JC (Clinical Laboratory, 2007)

Influencia de los polimorfismos del CYP2D6 Y CYP2C19 y del sexo en la farmacocinética del citalopram en voluntarios sanos - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2007)

Epileptic seizures caused by low valproic acid levels from an interaction with meropenem - Fudio S, Carcas A, Piñana E, Ortega R (Journal Of Clinical Pharmacy And Therapeutics, 2006)

Effect of losartan on blood pressure and heart rate after administration of a single 50mg dose to healthy subjects - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (Basic & Clinical Pharmacology & Toxicology, 2006)

Effects of single dose of bromazepam 6 mg on vital signs in healthy subjects - Ramírez, E.; Laosa, O.; Ochoa, D.; Llanos, L.; Martínez, E.; Borobia, A.; Carcas, A. J.; Guerra, P.; Frías, J.; (Basic & Clinical Pharmacology & Toxicology, 2006)

Pharmacokinetics differences between mycophenolic acids stabilized versus without stabilized by emit assay compared with hplc assay - Ramírez, E.; Lubomirov, R.; Llanos, L.; Duque, B.; Fudio, S.; Guerra, P.; Carcas, A. J.; Frías, J.; (Basic & Clinical Pharmacology & Toxicology, 2006)

Comparing Methods For The measurement of mycophenolic acid: HPLC And Emit Assay - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (Basic & Clinical Pharmacology & Toxicology, 2006)

Tolerability of alendronate 70mg after single dose in healthy subjects - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (Basic & Clinical Pharmacology & Toxicology, 2006)

Subtherapeutic tacrolimus trough levels on first days after renal transplantation is associated with organ rejection within three months after transplantation - Romero, I.; Borobia, A.; Jimenez, C.; Ramirez, E.; Gil, F.; Carcas, A.; Fudio, S.; Pinana, E.; (Basic & Clinical Pharmacology & Toxicology, 2006)

Lopinavir/ritonavir as single-drug therapy for maintenance of HlV-1 viral suppression - 48-week results of a randomized, controlled, open-label, proof-of-concept pilot clinical trial (OK study) - Arribas, J.R.; Pulido, F.; Delgado, R.; Lorenzo, A.; Miralles, P.; Arranz, A.; González-García, J.J.; Cepeda, C.; Hervás, R.; Paño, J.R.; Gaya, F.; Carcas, A.; et al. (Jaids-Journal Of Acquired Immune Deficiency Syndromes, 2005)

Estudio piloto sobre la eficacia y seguridad de la monoterapia con lopinavir/ritonavir para el mantenimiento de la supresión viral en pacientes infectados por el virus de la inmunodeficiencia humana - Peña Sanchez de Rivera, Jose Maria (Autor o Coautor); Perez Maestu, Ramon (Autor o Coautor); Carcas Sansuan, Antonio Javier (Autor o Coautor); Vazquez Rodriguez, Juan Jose (Director) Doctorando: Paño Pardo, José Ramón (2005)

Urinary concentrations and bactericidal activity against amoxicillin-nonsusceptible strains of Escherichia coli with single-dose, oral, sustained-release amoxicillin/clavulanic acid: A phase I, open-label, noncomparative clinical trial in healthy volunteers - Ponte C; Gracia M; Giménez M; Aguilar L; Maín C; Carpintero Y; Huelves L; Carcas A; Del Prado G; Soriano F (Clinical Therapeutics, 2005)

Placebo use in randomised controlled trials of psychiatric disorder - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2005)

A phase I, dose-finding study of irinotecan (CPT-11) short i.v. infusion combined with fixed dose of 5-fluorouracil (5-FU) protracted i.v. infusion in adult patients with advanced solid tumours - Sastre J, Paz-Ares L, Carcas A, Alfonso R, Grávalos C, Frías J, Guerra P, Pronk L, Cortés-Funes H, Díaz-Rubio E (Cancer Chemotherapy And Pharmacology, 2005)

Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers - Alou L, Aguilar L, Sevillano D, Giménez MJ, Laguna B, Echeverría O, Carcas A, Lubomirov R, Casal J, Prieto J (Journal Of Antimicrobial Chemotherapy, 2005)

Pulmonary damage and bacterial load in assessment of the efficacy of simulated human treatment-like amoxicillin (2,000 milligrams) therapy of experimental pneumococcal pneumonia caused by strains for which amoxicillin MICs Differ - Gracia M; Martínez-Marín C; Huelves L; Giménez M; Aguilar L; Carcas A; Ponte C; Soriano F (Antimicrobial Agents And Chemotherapy, 2005)

Bactericidal activity of amoxicillin against non-susceptible Streptococcus pneumoniae in an in vitro pharmacodynamic model simulating the concentrations obtained with the 2000/125 mg sustained-release co-amoxiclav formulation - Sevillano D, Calvo A, Giménez MJ, Alou L, Aguilar L, Valero E, Carcas A, Prieto J (Journal Of Antimicrobial Chemotherapy, 2004)

Análisis de la distribución del polimorfismo de los genes abcb1, cyp3a5 y del pseudogen cyp31p1 inhibidores de la hmg-coa reductasa en voluntarios sanos. - Frias Iniesta, Jesus A (Investigador/a); Carcas Sansuan, Antonio Javier (Investigador/a); Guerra Lopez, Pedro Enrique (Investigador principal (IP)) (2004)

Genotipación de voluntarios participantes en ensayos clínicos fase I: Herramienta útil para disminuir la variabilidad - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2004)

Phase I pharmacokinetic study of a single intravesical instillation of gemcitabine administered immediately after transurethral resection plus multiple random biopsies in patients with superficial bladder cancer - Palou J, Carcas A, Segarra J, Duque B, Salvador J, Garcia-Ribas I, Villavicencio H (Journal Of Urology, 2004)

Does Acetaminophen Interfere in the Antibiotic Treatment of Acute Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain? A Gerbil Model - Ponte C; Parra A; Cenjor C; García-Olmos M; Giménez M; Aguilar L; Carcas A; Soriano F (Pediatric Research, 2003)

Outcome trials of COX-2 selective inhibitors: Global safety evaluation does not promise benefits - Gomez Cerezo J; Lubomirov Hristov R; Carcas Sansuán A; Vázquez Rodríguez J (European Journal Of Clinical Pharmacology, 2003)

Soft-gel saquinavir and lopinavir/ritonavir double boosted pi regimen: a pharmacokinetic study - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2003)

Phase I study of inmediate intravesical single instillation of gemcitabine in patients with superficial bladder cancer after transurethral resection plus múltiple random biopsies - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2003)

Comparison of lormetazepam solution and capsules in healthy volunteers - Early exposure and drug pharmacokinetics - Guerra, P; Soto, A; Carcas, AJ; Sancho, A; Cassinello, A; Frías-Iniesta, J; (Clinical Drug Investigation, 2002)

Genotipación de la mutación Cyp2D6*4 en voluntarios sanos participantes en ensayos clínicos fase I. Utilidad del sistema LightCycler - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (2002)

Esteroides inhalados. - Villasante Fernández-Montes, C; Aguilar, M; Mayoralas Alises, Sagrario; Carcas Sansuan, Antonio Javier (Medicine, 2002)

Diferencias entre sexos en la eliminación renal de fármacos - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (2001)

Adverse events in phase I Clínical trials - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (2001)

Double peak in the plasma concentration curve of lovastatin - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (2001)

Serum cystatin C as a marker of glomerular filtration rate - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2001)

Sex and menstrual influence in Lorazepam pharmacokinetics - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (2001)

Sex differences in zolpidem pharmacokinetics - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2001)

Antibacterial properties of gemifloxacin and trovafloxacin in urine ex vivo: Phase I study - García-Calvo G; Parra A; Aguilar L; Ponte C; Giménez M; Carcas A; Kinzig-Schippers M; Soriano F (Antimicrobial Agents And Chemotherapy, 2001)

Gender differences in the disposition of metronidazole - Carcas AJ, Guerra P, Frias J, Soto A, Fernandez-Aijón A, Montuenga C, Govantes C (International Journal Of Clinical Pharmacology And Therapeutics, 2001)

A concordance analysis of algorithms for causality evaluation of adverse events within a phase I unit. VII World Conference on Clinical Pharmacology and Therapeutics - Carcas, AJ; Tabares, B; Ibanez, C; Garcia, O; Ruiz Antoran, Belen (2000)

Adverse drug reactions leading to hospital admission: a review of spanish studies - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (2000)

Absence of an interaction between ibuprofen and zaleplon - Sanchez Garcia P, Carcas A, Zapater P, Rosendo J, Paty I, Leister CA, Troy SM (American Journal Of Health-System Pharmacy, 2000)

A phase I/II clinical and pharmacologic study of dose-escalating and dose-sequencing administration of gemcitabine (G) and folinic acid (FA)/fluorouracil (FU) in advanced unresectable pancreatic cancer (APC). - Castellano, D; Paz-Ares, L; Pronk, L; Tomamira, MV; Tabernero, JM; Ciruelos, E; Carcas, A; Frias, J; Cortes-Funes, H; (Annals Of Oncology, 2000)

Average bioequivalence of two oral formulations of ticlopidine in healthy volunteers - Frías-Iniesta, J.; Soto-Matos, A.; Guerra, P.; Carcas, A.; Ruiz-Antoran, B.; Miranda, E.; Gomez-Barrio, E.; Govantes, C. (Current Therapeutic Research - Clinical And Experimental, 2000)

Comparative bioavailability of two oral 875/125mg sachet formulations of amoxicillin/clavulanic acid in healthy volunteers - Galvez-Mugica, MA; Frias-Iniesta, J; Guerra, P; Carcas, AJ; Fernandez-Aijon, A; Montuenga, C; Gomez-Barrios, E (Clinical Drug Investigation, 1999)

Participación de mujeres en los ensayos de bioequivalencia - Sachez P; Frias J; Carcas, A; Sancho A; Guerra, P; Soto, A; Ruiz Antoran, Belen (1999)

Methodological pitfalls in bioequivalence studies: sample size. Between-subject variability, single or multiple dose studies and metabolite determination - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (1999)

Women participation in bioequivalence trials - Carcas Sansuan, Antonio Javier; Guerra Lopez, Pedro Enrique; Frias Iniesta, Jesus A (1999)

Tobramycin penetration into epithelial lining fluid of patients with pneumonia - Carcas A; García-Satué J; Zapater P; Frías-Iniesta J (Clinical Pharmacology & Therapeutics, 1999)

Diferencias entre sexos en la farmacocinética de fluoxetina - Frias, J; Carcas, A; Guerra, P; Soto, A; Ruiz Antoran, Belen (1998)

Bioequivalence evaluation of 2 different oral formulations of ciprofloxacin in healthy volunteers - Galicia I; Frías-Iniesta J; Carcas A; Soto À; Gomez E; Miranda E; Fernandez A; Montuenga C (International Journal Of Clinical Pharmacology And Therapeutics, 1998)

Study of the bactericide activity of the combination amoxycillinclavulanic acid and its possible effects in the resistance ofbeta-lactamic drugs to Streptococcus pneumoniae - Carcas Sansuan, Antonio Javier (Medicina Clinica, 1998)

Estudio de la actividad bactericida de la combinación amoxicilina/ácido clavulánico y sus posibles efectos ante la resistencia a betalactámicos de Streptococcus pneumoniae - Prieto Prieto, J; Frías Iniesta, Jesús; Alou Cervera, Luis; Carcas Sansuan, Antonio Javier (Medicina Clinica, 1998)

Sex differences in fluoxetine pharmacokinetics - Soto, A; Carcas, A; Guerra, P; Galvez, MA; Ruiz Antoran, Belen; Frias, J; Miranda, E; Montuenga, C (Methods And Findings, 1998)

Sex differences in the disposition of piroxicam in young healthy volunteers - Frias, J; Galicia, I; Soto, A; Zapater, P; Guerra, P; Ibanez, C; Carcas, A J; Ruiz Antoran, Belen (1997)

Randomized controlled study to improve physician prescription by educational intervention - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1997)

Pharmacokinetic study of ebrotidine administered in multiple doses to healthy volunteers for 4 days - Frias J; Esteban C; Carcas A; Sánchez-García P; Albet C; Torres J; Marquez M; Ortiz J (Arzneimittel-Forschung/Drug Research, 1997)

Amoxicillin versus cefotaxime ex vivo antibacterial activity against Penicillin susceptible and penicillin resistant streptococcus pneumoniae strains - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1997)

Pharmacokinetics of Irinotecan (CPT 11) and 5 Fluorouracil (5 FU) in a dose finding study in adult patients with solid tumors - Carcas, AJ; Frias, J; Hernanz, A; Rubio, ED; CortesFunes, H; Sastre, J; PazAres, L; Vernillet, L; Martin, C; Huarte, L; (European Journal Of Cancer, 1997)

Cefminox versus cefoxitin in hysterectomy prophylaxis. Clinical efficacy and serum and tissue concentrations - Garrido R; Novo A; Quintana S; Macía M; Carrasco L; De Dios M; Romo J; Sanchez M; Vargas M; Lapuente F; Mieza Y; Coronel P; et al. (Clinical Drug Investigation, 1997)

Phase I dose finding study of irinotecan (CPT-11) over a short i.v. infusion combined with a fixed dose of 5-fluorouracil (5-FU) protracted continuous i.v. infusion in patients with advanced solid tumours - Sastre, J; PazAres, L; DiazRubio, E; CortesFunes, H; Carcas, A; Gruia, G; Herait, P; FdzChacon, C; Martin, C; Farr, I; (European Journal Of Cancer, 1997)

A bioequivalence study with two ciprofloxacin formulations - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1996)

Comparative kinetic and dynamic profile of two brands of diltiazem retard tablets - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1996)

Comparison of Cefminox kinetic parameters calculated by standard analysis and a population based program (NPEM) - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1996)

Kinetic and dynamic properties of repeated oral doses of Elgodipine (E) in healthy volunteers - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1996)

Evaluation of sex differences in the pharmacokinetics of ranitidine in humans - Abad-Santos F, Carcas AJ, Guerra P, Govantes C, Montuenga C, Gómez E, Fernández A, Frias J (Journal Of Clinical Pharmacology, 1996)

Qualitative assessment of drug use among a HIV seropositive population previously to a hospitalization. - Ibanez, RC; Esteban, CC; Carcas, SA; Frias, IJ; (Methods And Findings In Experimental And Clinical Pharmacology, 1996)

Neuroleptic malignant syndrome. Review of reports from FEDRA. - Mendoza, RM; Ibanez, RC; Esteban, CC; Ibanez, ML; Carcas, SA; Frias, IJ; (Methods And Findings In Experimental And Clinical Pharmacology, 1996)

Measurement of tobramycin in bronchoalveolar lavage fluid by a modified fluorescence polarization immunoassay - Govantes C, Carcas AJ, Garcia-Stue JL, Zapater P, Frias J (Journal Of Antimicrobial Chemotherapy, 1995)

Pharmacokinetics of 24 hour infusion of high dose metotrexate in paediatric patients. A bayesian pharmacokinetic study - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1995)

Tobramycin penetration into pulmonary lining fluid in patientes with pneumonia - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1995)

COMPARATIVE BIOAVAILABILITY OF A DISPERSIBLE FORMULATION OF DICLOFENAC AND FINDING OF DOUBLE PLASMA PEAKS - Macía MA, Frias J, Carcas AJ, Guerra P, Valiente R, Lucero ML (International Journal Of Clinical Pharmacology And Therapeutics, 1995)

Phase I clinical trials: Objectives and design - Carcas Sansuan A (Methods And Findings In Experimental And Clinical Pharmacology, 1995)

EFFECT OF DEXAMETHASONE ON THE DECREASE OF SERUM PHENYTOIN CONCENTRATIONS - Recuenco I, Espinosa E, García B, Carcas A (Annals Of Pharmacotherapy, 1995)

Análisis de la calidad de la prescripción en Atención Primaria - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1994)

CEFMINOX - CORRELATION BETWEEN IN-VITRO SUSCEPTIBILITY AND PHARMACOKINETICS AND SERUM BACTERICIDAL ACTIVITY IN HEALTHY-VOLUNTEERS - Aguilar L, Esteban C, Frias J, Pérez-Balcabao I, Carcas AJ, Dal-Ré R (Journal Of Antimicrobial Chemotherapy, 1994)

El efecto del carbón activado sobre la eliminación de digoxina en pacientes - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1992)

HOSPITALIZATIONS DUE TO PHARMACEUTICAL DRUGS - A PROSPECTIVE-STUDY - Garijo, B.; De Abajo, F.J.; Castro, M.A.S.; Lopo, C.R.; Carcas, A.; Frias, J. (Revista Clinica Espanola, 1991)

ADVERSE REACTIONS TO DRUGS AS THE CAUSE OF CONSULTATION TO THE EMERGENCY SERVICE OF A GENERAL-HOSPITAL - De Abajo, F.J.; Frias, J.; Lopo, C.R.; Garijo, B.; Castro, M.A.S.; Carcas, A.; Juarez, S.; Gil, A. (Medicina Clinica, 1989)

Clinical trials in everyday medical practice - López Alvarez M; Serrano Castro M; Carcas Sansuán A; García Alonso F (Revista Clinica Espanola, 1989)

Ensayo clinico cruzado y randomizado de biodisponibilidad relativa de dos formulaciones diferentes de amoxicilina tras la administración en dosis unica a voluntarios sanos - Frias Iniesta, Jesus A; Carcas Sansuan, Antonio Javier (Tiempos Médicos: Revista De Educación Médica Continuada, 1988)

Las reacciones adversas a fármacos como motivo de consulta al Servicio de Urgencias de un Hospital General - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1987)

CLINICAL RELEVANCE OF MONITORING SERUM LEVELS OF THEOPHYLLINE - Frias J; Carcas Sansuan A; Castro M; Lopez Serrano M; Alzamora F (Revista Clinica Espanola, 1987)

Programa piloto de cumunicación voluntaria de reacciones adversas a medicamentos en medio hospitalario - Frias Iniesta, Jesus A; Carcas Sansuan, Antonio Javier (1986)

The Clínical relevance of theophylline plasma levels - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1986)

Theophylline complicance in asthmatic outpatients - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1986)

Cumplimiento terapéutico en pacientes tratados con teofilina - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1986)

Niveles plasmáticos de digoxina: valor de una hoja específica de petición - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1986)

Repercusión de la monitorización de niveles plasmáticos de teofilina en la evolución clínica de los pacientes asmáticos ambulantes - Carcas Sansuan, Antonio Javier; Frias Iniesta, Jesus A (1986)

AMPHOTERICIN-B HEPATOTOXICITY - ABAJO, FJ; CARCAS, AJ; (British Medical Journal, 1986)

Monitorización terapéutica de los fármacos - Carcas Sansuan, Antonio Javier; Frías Iniesta, Jesús (Velázquez: Farmacología Básica Y Clínica, 2015)

IMPLEMENTING PHARMACOGENETICS: PHARMARRAY (R), ACODOSE (R) AND PHARMACOGENETIC CONSULTATION - Borobia, A. M.; Lubomirov, R.; Tong, H. Y.; Arias, P.; Tenorio, J.; Frias, J.; Lapunzina, P.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2013)

VANCOMYCIN-INDUCED ACUTE KIDNEY INJURY DETECTED BY A PROSPECTIVE PHARMACOVIGILANCE PROGRAM FROM LABORATORY SIGNALS - Ramirez, E.; Borobia, A. M.; Tong, H. Y.; Medrano, N.; Carcas, A. J.; Frias, J.; (Basic & Clinical Pharmacology & Toxicology, 2012)

EFFICIENCY AND EFFECTIVENESS OF THE USE OF AN ACENOCUMAROL PHARMACOGENETIC DOSING ALGORITHM VS. USUAL CARE EN PATIENTS WITH VENOUS THROMBOEMBOLIC DISEASE (VTD) INITIATING ORAL ANTICOAGULATION: STUDY PROTOCOL FOR A MULTICENTRIC RANDOMIZED CONTROLLED TRIAL - Borobia, A. M.; Ramirez, E.; Lubomirov, R.; Tong, H. Y.; Munoz-Romo, R.; Campos, A.; Frias-Iniesta, J.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2011)

SCREENING AND RECRUITMENT PROCEDURES OF HEALTHY VOLUNTEERS IN A PHASE I CLINICAL TRIAL UNIT: EXPERIENCE OF 38 BIOEQUIVALENCE STUDIES - Duque, B.; Borobia, A. M.; Mosquera, B.; Duran, Lopez J. L. .; Ramirez, E.; Lubomirov, R.; Carcas, A. J.; Guerra, P.; Frias, J.; (Basic & Clinical Pharmacology & Toxicology, 2011)

Methodological pitfalls in bioequivalence studies: sample size, between-subject and within-subject variability, single or multiple dose studies and metabolite determination. - Frias J; Guerra P; Soto À; García O; Carcas A (Methods And Findings In Experimental And Clinical Pharmacology, 1999)

Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial - Borobia, Alberto M.; Carcas, Antonio J.; Perez-Olmeda, Mayte; Castano, Luis; Jesus Bertran, Maria; Garcia-Perez, Javier; Campins, Magdalena; Portoles, Antonio; Gonzalez-Perez, Maria; Garcia Morales, Maria Teresa; Arana-Arri, Eunate; Aldea, Marta; et al. (Lancet, 2021)

SEVERE HYPONATREMIA IS OFTEN DRUG-INDUCED. 10-YEAR RESULTS OF A PROSPECTIVE PHARMACOVIGILANCE PROGRAM - Ramírez E; Rodríguez A; Queiruga J; García I; Díaz L; Martínez L; Muñoz R; Muñoz M; Tong H; Martínez J; Borobia A; Carcas A; et al. (Clinical Pharmacology & Therapeutics, 2019)

Inmediate: Results of a phase IIIB, open label randomised clinical trial to compare pain relief between methoxyflurane and standard of care analgesia for treating patients with trauma pain in spanish emergency departments - Borobia Perez, Alberto M.; Garcia Collado, Sergio; Carballo Cardona, Cesar; Capilla Pueyo, Rosa; Fernandez Alonso, Cesareo; Perez Torres, Ignacio; Llorens Soriano, Pedro; Casal Codesido, Jose Ramon; Arranz Betegon, Maria; Amador Barcela, Luis; Odiaga Andikoetxea, Aitor; Fernandez Testa, Anselma; et al. (Basic & Clinical Pharmacology & Toxicology, 2018)

Hepatotoxicity induced by acute and chronic paracetamol overdose in children: Where do we stand? - Tong HY, Medrano N, Borobia AM, Ruiz JA, Martínez AM, Martín J, Quintana M, García S, Carcas AJ, Ramírez E (World Journal Of Pediatrics, 2017)

Búsqueda de marcadores genéticos predictores de respuestas a fármacos biológicos en el tratamiento de la psoriasis - AYUSO GARCIA, MARIA DEL CARMEN TOMASA (Autor o Coautor); Garcia Garcia, Antonio (Autor o Coautor); Carcas Sansuan, Antonio Javier (Autor o Coautor); María Teresa Cabaleiro Ocampo (Director); Francisco Abad Santos (Director) Doctorando: Rocío Prieto Pérez (2015)

Estudio de la contribución de los factores genéticos a la variabilidad farmacocinética y farmacodinámica de los inhibidores de la HMG-CoA reductasa en voluntarios sanos - Gomez Cerezo, Jorge Francisco (Autor o Coautor); Abad Santos, Francisco (Autor o Coautor); Sanchez Ferrer, Carlos Felix (Autor o Coautor); Frias Iniesta, Jesus A (Director) Doctorando: Lubomirov Kristov, Rubin (2010)

Bioequivalence of allopurinol and its metabolite oxipurinol in two tablet formutations - Guerra, P; Frias, J; Ruiz Antoran, Belen; Soto, A; Carcas Sansuan, Antonio Javier; Carcas, A; Govantes, C; Montuenga, C; Fernandez, A (Journal Of Clinical Pharmacy And Therapeutics, 2001)

Identifying biomarkers of treatment response to ciclosporin in atopic dermatitis through multiomic predictive modelling: DERMATOMICS study protocol - Marin-Candon, A; Garcia-Garcia, I; Arias, P; Carcas, AJ; Diaz-Garcia, L; Ochoa, RF; Cano, NH; Pinto, PH; Gonzalez, MJ; Lopez-Granados, E; Martinez-Feito, A; Mayor-Ibarguren, A; et al. (Bmj Open, 2023)

Desarrollo y resultados de un programa de toxicovigilancia activa en un hospital universitario de tercer nivel - Carcas Sansuan, Antonio Javier (Director) Doctorando: Muñoz Romo, Raúl (2022)

Results of phase 2 randomized multi-center study to evaluate the safety and efficacy of infusion of memory T cells as adoptive therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia and/or lymphopenia (RELEASE NCT04578210) - Ferreras, C; Hernández-Blanco, C; Martín-Quirós, A; Al-Akioui-Sanz, K; Mora-Rillo, M; Ibáñez, F; Díaz-Almirón, M; Cano-Ochando, J; Lozano-Ojalvo, D; Jiménez-González, M; Goterris, R; Sánchez-Zapardiel, E; et al. (Cytotherapy, 2024)

Academia and industry agreement on a feasibility tool for first-time-in-human clinical trial units - Moraga, P; Prieto, P; Conradie, A; Benhayoun, M; Rousell, V; Davy, M; Fuhr, U; Arbos, RA; Abad-Santos, F; Portolés, A; Van Duinen, J; Carcas, AJ; et al. (Cts-Clinical And Translational Science, 2023)

Evaluation of factors associated with recruitment rates in early phase clinical trials based on the European Clinical Trials Register data - Alapont, PM; Prieto, P; Urroz, M; Jimenez, M; Carcas, AJ; Borobia, AM (Cts-Clinical And Translational Science, 2023)

Immunogenicity and reactogenicity of a first booster with BNT162b2 or full-dose mRNA-1273: A randomised VACCELERATE trial in adults ?75 years (EU-COVAT-1) - Neuhann, JM; Stemler, J; Carcas, AJ; Frías-Iniesta, J; Akova, M; Bethe, U; Heringer, S; Salmanton-García, J; Tischmann, L; Zarrouk, M; Cüppers, A; Grothe, J; et al. (Vaccine, 2023)

Results of a toxicovigilance program in a tertiary hospital of the community of Madrid, from January 2020 to August 2022 - Gómez, A; Guijarro, J; Torres, RM; Mayayo, R; Díaz, L; Borobia, AM; Carcas, AJ; Urroz, M (Clinical Toxicology, 2023)

Advancing pharmacogenetic testing in a tertiary hospital: a retrospective analysis after 10 years of activity - Stewart, S; Dodero-Anillo, JM; Guijarro-Eguinoa, J; Arias, P; De las Huertas, AGL; Seco-Meseguer, E; García-García, I; García, ER; Rodríguez-Antolín, C; Carcas, AJ; Rodriguez-Novoa, S; Rosas-Alonso, R; et al. (Frontiers In Pharmacology, 2023)

DEVELOPMENT AND VALIDATION OF A TOXICOVIGILANCE SYSTEM WITH AUTOMATIC DETECTION OF CASES - Caparros, A. P.; Munoz-Romo, R.; Quintana, M.; Borobia, A. M.; Frias, J.; Carcas, A. J.; (Basic & Clinical Pharmacology & Toxicology, 2012)

PILOT STUDY ON THE ACUTE PAIN MANAGEMENT IN EMERGENCIES - Krauel-Bidwell, L.; Caparros, A. P.; Quintana, M.; Carcas, A. J.; Frias, J.; Borobia, A. M.; (Basic & Clinical Pharmacology & Toxicology, 2012)

TOXICOLOGICAL SURVEILLANCE IN A NEWLY ESTABLISHED UNIT OF CLINICAL TOXICOLOGY - Muñoz-Romo, R; Borobia-Peréz, AM; Quintana-Díaz, M; Martínez-Virto, AM; Yang-Tong, H; Krauel-Bidwell, L; Egaña-Chopitea, A; Ramirez-García, E; Frías-Iniesta, J; Carcas-Sansuán, AJ (Basic & Clinical Pharmacology & Toxicology, 2011)