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Bautista Aguilera, Óscar Mauricio

Química Orgánica y Química Inorgánica / Universidad de Alcalá

Publications

Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

  • Bautista-Aguilera, O.M.
  • Esteban, G.
  • Bolea, I.
  • Nikolic, K.
  • Agbaba, D.
  • Moraleda, I.
  • Iriepa, I.
  • Samadi, A.
  • Soriano, E.
  • Unzeta, M.
  • Marco-Contelles, J.
... View more Collapse

European Journal of Medicinal Chemistry (p. 82-95) - 2014

10.1016/j.ejmech.2013.12.028 View at source

  • ISSN/ISBN 0223-5234

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

  • Wang, L.
  • Esteban, G.
  • Ojima, M.
  • Bautista-Aguilera, O.M.
  • Inokuchi, T.
  • Moraleda, I.
  • Iriepa, I.
  • Samadi, A.
  • Youdim, M.B.H.
  • Romero, A.
  • Soriano, E.
  • Herrero, R.
  • Fernández Fernández, A.P.
  • Ricardo-Martínez-Murillo, null
  • Marco-Contelles, J.
  • Unzeta, M.
... View more Collapse

European Journal of Medicinal Chemistry (p. 543-561) - 2014

Editor: Elsevier Masson s.r.l.

10.1016/j.ejmech.2014.04.078 View at source

  • ISSN/ISBN 1768-3254

Acetylcholinesterase inhibition of diversely functionalized quinolinones for alzheimer’s disease therapy

  • Bautista-Aguilera, Ó.M.
  • Ismaili, L.
  • Chioua, M.
  • Andrys, R.
  • Schmidt, M.
  • Bzonek, P.
  • Martínez-Grau, M.Á.
  • Beadle, C.D.
  • Vetman, T.
  • López-Muñoz, F.
  • Iriepa, I.
  • Refouvelet, B.
  • Musilek, K.
  • Marco-Contelles, J.
... View more Collapse

International Journal of Molecular Sciences (p. 1-20) - 2020

Editor: MDPI AG

10.3390/ijms21113913 View at source

  • ISSN/ISBN 1422-0067

Predicting targets of compounds against neurological diseases using cheminformatic methodology

  • Nikolic, K.
  • Mavridis, L.
  • Bautista-Aguilera, O.M.
  • Marco-Contelles, J.
  • Stark, H.
  • Do Carmo Carreiras, M.
  • Rossi, I.
  • Massarelli, P.
  • Agbaba, D.
  • Ramsay, R.R.
  • Mitchell, J.B.O.
... View more Collapse

Journal of Computer-Aided Molecular Design (p. 183-198) - 2015

Editor: Kluwer Academic Publishers

10.1007/s10822-014-9816-1 View at source

  • ISSN/ISBN 1573-4951

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

  • Bautista-Aguilera, O.M.
  • Samadi, A.
  • Chioua, M.
  • Nikolic, K.
  • Filipic, S.
  • Agbaba, D.
  • Soriano, E.
  • De Andrés, L.
  • Rodríguez-Franco, M.I.
  • Alcaro, S.
  • Ramsay, R.R.
  • Ortuso, F.
  • Yañez, M.
  • Marco-Contelles, J.
... View more Collapse

Journal of Medicinal Chemistry (p. 10455-10463) - 2014

Editor: American Chemical Society

10.1021/jm501501a View at source

  • ISSN/ISBN 1520-4804

Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

  • Bautista-Aguilera, O.M.
  • Budni, J.
  • Mina, F.
  • Medeiros, E.B.
  • Deuther-Conrad, W.
  • Entrena, J.M.
  • Moraleda, I.
  • Iriepa, I.
  • López-Muñoz, F.
  • Marco-Contelles, J.
... View more Collapse

Journal of Medicinal Chemistry (p. 6937-6943) - 2018

Editor: American Chemical Society

10.1021/acs.jmedchem.8b00848 View at source

  • ISSN/ISBN 1520-4804

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

  • Benchekroun, M.
  • Romero, A.
  • Egea, J.
  • León, R.
  • Michalska, P.
  • Buendía, I.
  • Jimeno, M.L.
  • Jun, D.
  • Janockova, J.
  • Sepsova, V.
  • Soukup, O.
  • Bautista-Aguilera, O.M.
  • Refouvelet, B.
  • Ouari, O.
  • Marco-Contelles, J.
  • Ismaili, L.
... View more Collapse

Journal of Medicinal Chemistry (p. 9967-9973) - 2016

Editor: American Chemical Society

10.1021/acs.jmedchem.6b01178 View at source

  • ISSN/ISBN 1520-4804

Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates

  • Petcu, A.S.
  • Lázaro-Milla, C.
  • Rodríguez, F.J.
  • Iriepa, I.
  • Bautista-Aguilera, O.M.
  • Aragoncillo, C.
  • Alonso, J.M.
  • Almendros, P.
... View more Collapse

Journal of Organic Chemistry - 2023

Editor: American Chemical Society

10.1021/acs.joc.3c00611 View at source

  • ISSN/ISBN 1520-6904

Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer’s disease

  • Chioua, M.
  • Pérez, M.
  • Bautista-Aguilera, O.M.
  • Yañez, M.
  • López, M.G.
  • Romero, A.
  • Cacabelos, R.
  • de la Bellacasa, R.P.
  • Brogi, S.
  • Butini, S.
  • Borrell, J.I.
  • Marco-Contelles, J.
... View more Collapse

Mini-Reviews In Medicinal Chemistry (p. 648-658) - 1/5/2015

Editor: Bentham Science Publishers B.V.

10.2174/1389557515666150219130156 View at source

  • ISSN 13895575
  • ISSN/ISBN 1875-5607

Synthesis and biological evaluation of benzochromenopyrimidinones as cholinesterase inhibitors and potent antioxidant, non-hepatotoxic agents for Alzheimer's disease

  • Dgachi, Y.
  • Bautista-Aguilera, O.M.
  • Benchekroun, M.
  • Martin, H.
  • Bonet, A.
  • Knez, D.
  • Godyń, J.
  • Malawska, B.
  • Gobec, S.
  • Chioua, M.
  • Janockova, J.
  • Soukup, O.
  • Chabchoub, F.
  • Marco-Contelles, J.
  • Ismaili, L.
... View more Collapse

Molecules - 2016

Editor: MDPI AG

10.3390/molecules21050634 View at source

  • ISSN/ISBN 1420-3049

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This researcher has no supervised thesis.

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Last data update: 4/24/24 1:00 PM