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Author profile at the institutional portal

Cuadrado Pastor, Antonio antonio.cuadrado@uam.es

Bioquímica / Universidad Autónoma de Madrid

Publications

Glycogen synthase kinase-3 beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2

  • Salazar, Maria
  • Rojo, Ana I.
  • Velasco, Diego
  • de Sagarra, Rosa Maria
  • Cuadrado, Antonio;

Journal Of Biological Chemistry (p. 14841-14851) - 26/5/2006

10.1074/jbc.m513737200 View at source

  • ISSN 00219258

Interleukin-1 beta enhances GABA(A) receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway - Relevance to sepsis-associated encephalopathy

  • Serantes R, Arnalich F, Figueroa M, Salinas M, Andrés-Mateos E, Codoceo R, Renart J, Matute C, Cavada C, Cuadrado A, Montiel C

Journal Of Biological Chemistry (p. 14632-14643) - 26/5/2006

10.1074/jbc.m512489200 View at source

  • ISSN 00219258

Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor

  • Marinissen M
  • Tanos T
  • Bolós M
  • De Sagarra M
  • Coso O
  • Cuadrado A

Journal Of Biological Chemistry (p. 11332-11346) - 21/4/2006

10.1074/jbc.m512199200 View at source

  • ISSN 00219258

Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

  • Gonzalez-Santiago, L
  • Suarez, Y
  • Zarich, N
  • Munoz-Alonso, M J
  • Cuadrado, A
  • Martinez, T
  • Goya, L
  • Iradi, A
  • Saez-Tormo, G
  • Maier, J V
  • Moorthy, A
  • Cato, A C B
  • Rojas, J M
  • Munoz, A
... View more Collapse

Cell Death And Differentiation (p. 1968-1981) - 1/11/2006

10.1038/sj.cdd.4401898 View at source

  • ISSN 13509047

Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice

  • Rojo AI
  • Montero C
  • Salazar M
  • Close RM
  • Fernández-Ruiz J
  • Sánchez-González MA
  • De Sagarra MR
  • Jackson-Lewis V
  • Cavada C
  • Cuadrado A
... View more Collapse

European Journal Of Neuroscience (p. 1874-1884) - 1/10/2006

10.1111/j.1460-9568.206.05060.x

  • ISSN 0953816X
  • iMarina

Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappa B

  • Rojo, AI
  • Salinas, M
  • Martin, D
  • Perona, R
  • Cuadrado, A;

Journal Of Neuroscience (p. 7324-7334) - 18/8/2004

10.1523/jneurosci.2111-04.2004 View at source

  • ISSN 15292401

Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells

  • Sánchez-Sánchez N
  • Riol-Blanco L
  • De La Rosa G
  • Puig-Kröger A
  • García-Bordas J
  • Martín D
  • Longo N
  • Cuadrado A
  • Cabañas C
  • Corbí AL
  • Sánchez-Mateos P
  • Rodríguez-Fernández JL
... View more Collapse

Blood (p. 619-625) - 1/8/2004

10.1182/blood-2003-11-3943 View at source

  • ISSN 00064971

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1

  • Vicente Manzanares, Miguel
  • Sanchez Madrid, Francisco
  • Cuadrado Pastor, Antonio
  • Gutierrez-Lopez, MD
  • Rojo, AI
  • Perez-Alvarez, MJ
  • Bustelo, XR
  • Rodriguez-Fernandez, JL
  • Cabanas, C
... View more Collapse

Journal Of Biological Chemistry (p. 16194-16205) - 16/4/2004

10.1074/jbc.m400905200 View at source

  • ISSN 00219258

Regulation of Heme Oxygenase-1 Expression through the Phosphatidylinositol 3-Kinase/Akt Pathway and the Nrf2 Transcription Factor in Response to the Antioxidant Phytochemical Carnosol

  • Martin D
  • Rojo A
  • Salinas M
  • Diaz R
  • Gallardo G
  • Alam J
  • Ruiz De Galarreta C
  • Cuadrado A
... View more Collapse

Journal Of Biological Chemistry (p. 8919-8929) - 5/3/2004

10.1074/jbc.m309660200 View at source

  • ISSN 00219258

Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo

  • Salinas, M
  • Wang, JL
  • de Sagarra, MR
  • Martin, D
  • Rojo, AI
  • Martin-Perez, J
  • de Montellano, PRO
  • Cuadrado, A;
... View more Collapse

Febs Letters (p. 90-94) - 3/12/2004

10.1016/j.febslet.2004.10.077 View at source

  • ISSN 00145793

This researcher has no books.

Perspectives on the Clinical Development of NRF2-Targeting Drugs

  • Lastra D
  • Fernández-Ginés R
  • Manda G
  • Cuadrado A

Handbook Of Experimental Pharmacology (p. 93-141) - 1/1/2021

10.1007/164_2020_381 View at source

  • ISSN 01712004

Reactive Oxygen Species Network Pharmacology and Therapeutic Applications Preface

  • Schmidt, HHHW
  • Ghezzi, P
  • Cuadrado, A

Handbook Of Experimental Pharmacology (p. V-VI) - 1/1/2021

  • ISSN 01712004
  • iMarina

Regulation of phospholipids metabolism by Ras proteins

  • CARNERO, A
  • CUADRADO, A
  • DOLFI, F
  • JIMENEZ, B
  • DELPESO, L
  • ESTEVE, P
  • MONTANER, S
  • EMBADE, N
  • RAMOS, A
  • LACAL, JC;
... View more Collapse

Gtpase-Controlled Molecular Machines. Challenges In Moderm Medicine (p. 321-340) - 1/1/1994

  • iMarina

TRANSCRIPTION FACTOR NRF2 REGULATES THE PERMEABILITY OF THE BLOOD BRAIN BARRIER AT THE LEVEL OF ANGPT1/2-TIE2 SIGNALING

  • Cazalla, E
  • Garcia-Yague, AJ
  • Pajares, M
  • Jimenez-Villegas, J
  • Cuadrado, A

Free Radical Biology And Medicine (p. 16-17) - 20/5/2023

10.1016/j.freeradbiomed.2023.03.083 View at source

  • ISSN 08915849

EXPLORING THE INTERPLAY OF TRANSCRIPTION FACTOR NRF2, REDOX HOMEOSTASIS AND RNA METABOLISM IN ALS PATHOGENESIS

  • Jimenez-Villegas, J
  • Cuadrado, A
  • Rojo, AI

Free Radical Biology And Medicine (p. 7-7) - 20/5/2023

10.1016/j.freeradbiomed.2023.03.051 View at source

  • ISSN 08915849

TARGETING THE NRF2/BETATRCP AXIS IN LIVER DISEASE

  • Cuadrado, A
  • Rojo, AI
  • Fernandez-Gines, R

Free Radical Biology And Medicine (p. 10-10) - 20/8/2022

  • ISSN 08915849
  • iMarina

Targeting NRF2 for brain protection in Alzheimer's disease

  • Cuadrado, A
  • Rojo, A I
  • Manda, G

Febs Open Bio (p. 60-61) - 1/7/2021

  • ISSN 22115463
  • iMarina

An inhibitor of the NRF2-beta TrCP interaction suppresses lipopolysaccharid-mediated inflammation in vitro and in vivo

  • Fernandez-Gines, Raquel
  • Rojo, Ana I.
  • Antonio Encinar, Jose
  • Wells, Geoffrey
  • Cuadrado, Antonio;

FREE RADICAL BIOLOGY AND MEDICINE - 1/1/2021

10.1016/j.freeradbiomed.2020.12.298 View at source

  • ISSN 08915849

Regulation of the extracellular matrix glycoprotein Reelin by the transcription factor NRF2: A protective mechanism for the brain under oxidative stress

  • Garcia-Yague, Angel J.
  • Cuadrado, Antonio;

Free Radical Biology And Medicine - 1/1/2021

10.1016/j.freeradbiomed.2020.12.398 View at source

  • ISSN 08915849

Altered inflammation and redox networks in the blood of patients with mild dementia

  • Cuadrado, Antonio
  • Milanesi, Elena
  • Dobre, Maria
  • Cucos, Anca
  • Pinol-Ripoll, Gerard
  • Tudose, Catalina
  • Niculescu, Gabriela
  • Manda, Gina;
... View more Collapse

Free Radical Biology And Medicine - 1/1/2021

10.1016/j.freeradbiomed.2020.12.407 View at source

  • ISSN 08915849

WIP induces oxidant tolerance in glioblastoma cells through NRF2/KEAP1 axis regulation

  • Lastra, Diego
  • Robledinos-Anton, Natalia
  • Cuadrado, Antonio
  • Escoll, Maribel;

Free Radical Biology And Medicine - 1/1/2021

10.1016/j.freeradbiomed.2020.12.422 View at source

  • ISSN 08915849

Distinctive under-expression profile of inflammatory and redox genes in the blood of elderly patients with cardiovascular disease

  • Milanesi, Elena
  • Manda, Gina
  • Dobre, Maria
  • Codrici, Elena
  • Victoria Neagoe, Ionela
  • Ovidiu Popescu, Bogdan
  • Spiru, Luiza
  • Tudose, Catalina
  • Ioan Prada, Gabriel
  • Irene Davidescu, Eugenia
  • Pinol-Ripoll, Gerard
  • Cuadrado, Antonio;
... View more Collapse

Free Radical Biology And Medicine - 1/1/2021

10.1016/j.freeradbiomed.2020.12.348 View at source

  • ISSN 08915849

Oxidative stress and inflammation gene expression changes in cognitive impairment

  • Milanesi, E.
  • Dobre, M.
  • Popescu, B. O.
  • Prada, G.
  • Bajenaru, O.
  • Tudose, C.
  • Spiru, L.
  • Manda, G.
  • Cuadrado, A.;
... View more Collapse

Febs Open Bio (p. 229-229) - 1/1/2019

  • ISSN 22115463
  • iMarina

This researcher has no working papers.

This researcher has no technical reports.

NRF2 as a novel therapeutic target in early and intermediate age-related macular degeneration

  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 01-12-2022 - 30-11-2025

Type of funding: Internal

Amount of funding: 253275,00 Euros.

  • iMarina

DESARROLLO DE NUEVOS FÁRMACOS ANTI-INFLAMATORIOS BASADOS EN LA ACTIVACIÓN DEL FACTOR DE TRANSCRIPCIÓN NRF2

  • Rojo Sanchís, Ana Isabel (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 01-12-2021 - 30-11-2023

Type of funding: National

Amount of funding: 149500,00 Euros.

  • iMarina

El factor de transcripción nrf2 en la patofisiología de la enfermedad de Alzheimer

  • Pajares Cabetas, Marta (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • FERNANDEZ GINES, RAQUEL (Investigador/a)
  • LASTRA MARTINEZ, DIEGO (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
  • Robledinos Anton, Natalia (Investigador/a)
  • Escoll Guerrero, Maria Isabel (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador principal (IP))
... View more Collapse

Period: 01-06-2020 - 31-05-2023

Type of funding: National

Amount of funding: 369050,00 Euros.

  • iMarina

Investigacion traslacional sobre la regulacion farmacologica nrf2 en enfermedades no transmisibles

  • ENCINAR HIDALGO, JOSÉ ANTONIO (Investigador/a)
  • RODRIGUEZ FRANCO, Maria Isabel (Investigador/a)
  • Fernández Fernández, Inmaculada (Investigador/a)
  • FUENTES RODRIGUEZ, JOSE MANUEL (Investigador/a)
  • MATIAS-GUIU ANTEM, JORDI (Investigador/a)
  • DUARTE PÉREZ, JOSÉ MANUEL (Investigador/a)
  • LABANDEIRA GARCIA, JOSE LUIS (Investigador/a)
  • Montaner Villalonga, Joan (Investigador/a)
  • OLIVA MIGUEL, BALDOMERO (Investigador/a)
  • FERRÁNDIZ MANGLANO, MARIA LUISA (Investigador/a)
  • Garcia Lopez, Manuela (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
... View more Collapse

Period: 01-01-2020 - 31-12-2021

Type of funding: National

Amount of funding: 20000,00 Euros.

  • iMarina

Desarrollo de fármacos activadores de NRF2 para terapias innovadoras de la enfermedad de alzheimer

  • Pajares Cabetas, Marta (Investigador/a)
  • GARCIA YAGUE, ANGEL JUAN (Investigador/a)
  • Robledinos Anton, Natalia (Investigador/a)
  • Rojo Sanchís, Ana Isabel (Investigador/a)
  • Garcia Lopez, Manuela (Investigador principal (IP))
  • MARTA PAJARES CABETAS (Miembro del equipo de investigación)
  • Angel Juan Garcia Yague (Miembro del equipo de investigación)
  • NATALIA ROBLEDINOS ANTON (Miembro del equipo de investigación)
  • MARIA ISABEL ESCOLL GUERRERO (Miembro del equipo de investigación)
  • Ana Isabel Rojo Sanchis (Miembro del equipo de investigación)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
... View more Collapse

Period: 01-01-2018 - 31-12-2021

Amount of funding: 95091,66 Euros.

  • iMarina

Aproximación teranostica avanzada en cáncer combinando terapia fotodinámica y nano partículas

  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 01-05-2016 - 30-04-2019

Type of funding: National

Amount of funding: 49000,00 Euros.

  • iMarina

RED DE INVESTIGACION EN NRF2 COMO NODO DEL PATOGENOSOMA

  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 01-12-2015 - 30-11-2017

Type of funding: National

Amount of funding: 35000,00 Euros.

  • iMarina

PAPEL DE NRF2 COMO MODULADOR ANTIOXIDANTE DE LA NEUROINFLAMACION EN LA ENFERMEDAD DE ALZHEIMER

  • Cuadrado Pastor, Antonio (Investigador principal (IP))
  • Rada Llano, Patricia Pilar (Investigador/a)
  • Ana Isabel Rojo Sanchis (Investigador/a)
  • Lastres Becker, Isabel (Investigador/a)
  • Angel Juan Garcia Yague (Investigador/a)

Period: 01-01-2014 - 31-12-2016

  • iMarina

Papel del factor de transcripción NRF2 en diferenciación neuronal, neuroprotección y neuroinflamación.

  • Rada Llano, Patricia Pilar (Investigador/a)
  • Espada Serrano, Sandra (Investigador/a)
  • Nuria Troyano Suarez (Investigador/a)
  • Nadia Innamorato (Investigador/a)
  • Lastres Becker, Isabel (Investigador/a)
  • Angel Juan Garcia Yague (Investigador/a)
  • Ana Isabel Rojo Sanchis (Investigador/a)
  • Agnieszka Jazwa (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))
... View more Collapse

Period: 01-01-2011 - 31-12-2013

  • iMarina

Regulación del factor de transcripción NRF2, organizador central de la respuesta antioxiantes célular por la vía P13K/AKT/GSK-3BETA Utilidad terpeutica en modelos animales parkinson.

  • Sagarra Conde, Maria Rosa (Investigador/a)
  • Ana Isabel Rojo Sanchis (Investigador/a)
  • Cuadrado Pastor, Antonio (Investigador principal (IP))

Period: 10-01-2007 - 10-04-2010

  • iMarina

Análisis de la función del factor de transcripción NRF2 en la progresión tumoral

  • Antonio Cuadrado (Director)
  • Escoll Guerrero, Maria Isabel (Director) Doctorando: Diego Lastra Martínez

13/1/2023

  • iMarina

Novel NRF2 inducers and selective MAO-B inhibitors for the treatment of Parkinson’s disease

  • Rafael León Martínez (Director)
  • Antonio Cuadrado (Director) Doctorando: Pablo Duarte Flórez

16/9/2022

  • iMarina

Desarrollo de nuevos moduladores de actividad del factor de transcripción NRF2

  • Antonio Cuadrado (Director)
  • Ana Isabel Rojo Sanchis (Director) Doctorando: Raquel Fernández Ginés

1/1/2022

  • iMarina

Hematopoietic Stem Cell Gene Editing for the Treatment of Pyruvate Kinase Deficiency

  • Quintana Bustamante, Oscar (Director)
  • Segovia Sanz, José C. (Director)
  • Cuadrado Pastor, Antonio (Tutor) Doctorando: Fañanás Baquero, Sara

18/9/2020

  • iMarina

The coming of age of selective types of autophagy for the treatment of Alzheimer´s disease and related tauopathies

  • Buendia Abaitua, Izaskun (Autor o Coautor)
  • Cuadrado Pastor, Antonio (Autor o Coautor)
  • Garcia Lopez, Manuela (Director)

1/1/2020

  • iMarina

Identificación de proteínas asociadas al inhibidor de la traducción elF4E-BP2 como nuevas dianas en la isquemia cerebral

  • Alcázar González, Alberto (Director)
  • Cuadrado Pastor, Antonio (Tutor) Doctorando: Martínez Alonso, Emma

14/6/2019

  • iMarina

Orchestration of the neural stem cell fate by NRF2 and TAZ

  • Portillo Perez, Francisco (Tutor)
  • Cuadrado, Antonio (Director)
  • Rojo Sanchís, Ana Isabel (Autor o Coautor)

1/1/2019

  • iMarina

Transcription factor NRF2 regulates the expression of autophagy genes

  • Antonio Cuadrado (Director)
  • Ana Isabel Rojo Sanchis (Director)
  • Rojo Sanchís, Ana Isabel (Autor o Coautor) Doctorando: Marta Pajares Cabetas

19/10/2018

  • iMarina

Papel de la oligomerización de las pl3k de clase ia p110 alfa y p110 beta en la regulación de la actividad de pten

  • Cuadrado Pastor, Antonio (Autor o Coautor)
  • Lopez Corcuera, Beatriz (Autor o Coautor)
  • Carrera Ramírez, Ana Clara (Director)
  • Lopez Corcuera, Beatriz (Tutor)

1/1/2014

  • iMarina

Protection against paracetamol-induced adverse effects in the liver by the inhibition of the protein tyrosine phosphatase 1B

  • Cuadrado Pastor, Antonio (Autor o Coautor)
  • Martínez Valverde, Angela María (Director)

1/1/2013

  • iMarina

Treatment of NRF2-related diseases

  • Cuadrado Pastor, Antonio (Autor o Coautor)
  • FERNANDEZ GINES, RAQUEL (Autor o Coautor)
  • Leon Martinez, Rafael (Autor o Coautor)
  • FRANCO GONZALEZ, JUAN FELIPE (Autor o Coautor)
  • Garcia Lopez, Manuela (Autor o Coautor)
  • Rojo Sanchís, Ana Isabel (Autor o Coautor)

21/7/2022

  • iMarina

Tetrahydro-spiroindoline-pyrrolopyrrole-triones inhibitors of the NRF2-BETA-TRCP interaction for use in the treatment of fatty liver disease

  • Rojo Sanchís, Ana Isabel (Autor o Coautor)
  • RODRIGUEZ FRANCO, Maria Isabel (Autor o Coautor)
  • Garcia Lopez, Manuela (Autor o Coautor)
  • FRANCO GONZALEZ, JUAN FELIPE (Autor o Coautor)
  • FERNANDEZ GINES, RAQUEL (Autor o Coautor)
  • Leon Martinez, Rafael (Autor o Coautor)
  • ENCINAR, JOSÉ ANTONIO (Autor o Coautor)
  • Cuadrado Pastor, Antonio (Autor o Coautor)
... View more Collapse

13/1/2022

  • iMarina

Compuestos inductores de NRF2 e inhibidores de MAO-b para el tratamiento de la enfermedad de parkinson

  • Cuadrado Pastor, Antonio (Autor o Coautor)

1/1/2022

  • iMarina
Last data update: 4/24/24 1:01 PM